4QP7

Crystal Structure of ERK2 in complex with 2-(1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine

Summary for 4QP7

• Entry DOI: 10.2210/pdb4qp7/pdb
• Related: 4QP1 4QP2 4QP3 4QP4 4QP6 4QP8 4QP9 4QPA
• Descriptor: Mitogen-activated protein kinase 1, 2-(1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine (3 entities in total)
• Functional Keywords: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytoskeleton, spindle : P28482
• Total number of polymer chains: 2
• Total formula weight: 85468.08

Authors

Yin, J.,Wang, W. (deposition date: 2014-06-22, release date: 2015-09-23, Last modification date: 2024-02-28)

• Primary citation: Burdick, D.J.,Wang, S.,Heise, C.,Pan, B.,Drummond, J.,Yin, J.,Goeser, L.,Magnuson, S.,Blaney, J.,Moffat, J.,Wang, W.,Chen, H.; Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors.; Bioorg.Med.Chem.Lett., 25:4728-4732, 2015; PubMed: 26338362; DOI: 10.1016/j.bmcl.2015.08.048

Experimental method

X-RAY DIFFRACTION (2.249 Å)