4QP9
Crystal Structure of ERK2 in complex with 7-(1-propyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine
Summary for 4QP9
Entry DOI | 10.2210/pdb4qp9/pdb |
Related | 4QP1 4QP2 4QP3 4QP4 4QP6 4QP7 4QP8 4QPA |
Descriptor | Mitogen-activated protein kinase 1, 7-(1-propyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine (3 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, spindle : P28482 |
Total number of polymer chains | 1 |
Total formula weight | 42853.20 |
Authors | |
Primary citation | Burdick, D.J.,Wang, S.,Heise, C.,Pan, B.,Drummond, J.,Yin, J.,Goeser, L.,Magnuson, S.,Blaney, J.,Moffat, J.,Wang, W.,Chen, H. Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25:4728-4732, 2015 Cited by PubMed: 26338362DOI: 10.1016/j.bmcl.2015.08.048 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.001 Å) |
Structure validation
Download full validation report