4QP1

Crystal structure of ERK2 in complex with N-cyclohexyl-9H-purin-6-amine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Mitogen-activated protein kinase 1	polymer	369	42627.8	2	UniProt (P28482) Pfam (PF00069)	Homo sapiens (human)	MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2
2	C, E (A, B)	N-BENZYL-9H-PURIN-6-AMINE	non-polymer		225.2	2	Chemie (EMU)
3	D, F (A, B)	IMIDAZOLE	non-polymer		69.1	2	Chemie (IMD)
4	G, H (A, B)	water	water		18.0	186	Chemie (HOH)

Sequence modifications

A, B: 1 - 360 (UniProt: P28482)

PDB	External Database	Details
Met -8	-	expression tag
Gly -7	-	expression tag
Ser -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	85255.7
Non-Polymers*	Number of molecules	4
	Total formula weight	588.7
All*	Total formula weight	85844.3

*Water molecules are not included.