4QTE

Structure of ERK2 in complex with VTX-11e, 4-{2-[(2-CHLORO-4-FLUOROPHENYL)AMINO]-5-METHYLPYRIMIDIN-4-YL}-N-[(1S)-1-(3-CHLOROPHENYL)-2-HYDROXYETHYL]-1H-PYRROLE-2-CARBOXAMIDE

Summary for 4QTE

Entry DOI	10.2210/pdb4qte/pdb
Related	4QTA 4QTB 4QTC 4QTD
Descriptor	Mitogen-activated protein kinase 1, 1,2-ETHANEDIOL, SULFATE ION, ... (6 entities in total)
Functional Keywords	structural genomics, structural genomics consortium, sgc, transferase, kinase, mapk, signalling, inhibitor, allosteric, structural genomics consortium (sgc), transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, spindle (By similarity): P28482
Total number of polymer chains	1
Total formula weight	43948.80
Authors	Chaikuad, A.,Savitsky, P.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2014-07-07, release date: 2014-07-23, Last modification date: 2023-09-20)
Primary citation	Chaikuad, A.,M C Tacconi, E.,Zimmer, J.,Liang, Y.,Gray, N.S.,Tarsounas, M.,Knapp, S. A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics. Nat.Chem.Biol., 10:853-860, 2014 Cited by PubMed: 25195011 DOI: 10.1038/nchembio.1629 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation