6O1N
| Cryo-EM structure of TRPV5 (1-660) in nanodisc | Descriptor: | Transient receptor potential cation channel subfamily V member 5 | Authors: | Dang, S, van Goor, M.K, Asarnow, D, Wang, Y, Julius, D, Cheng, Y, van der Wijst, J. | Deposit date: | 2019-02-21 | Release date: | 2019-04-24 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural insight into TRPV5 channel function and modulation. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6O1U
| Cryo-EM structure of TRPV5 W583A in nanodisc | Descriptor: | Transient receptor potential cation channel subfamily V member 5 | Authors: | Dang, S, van Goor, M.K, Asarnow, D, Wang, Y, Julius, D, Cheng, Y, van der Wijst, J. | Deposit date: | 2019-02-21 | Release date: | 2019-04-24 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural insight into TRPV5 channel function and modulation. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6O1P
| Cryo-EM structure of full length TRPV5 in nanodisc | Descriptor: | Transient receptor potential cation channel subfamily V member 5 | Authors: | Dang, S, van Goor, M.K, Asarnow, D, Wang, Y, Julius, D, Cheng, Y, van der Wijst, J. | Deposit date: | 2019-02-21 | Release date: | 2019-04-24 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural insight into TRPV5 channel function and modulation. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6PBF
| ZINC9155420-bound TRPV5 in nanodiscs | Descriptor: | (1S)-1-(4-oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)ethyl [(2S)-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetate, Transient receptor potential cation channel subfamily V member 5 | Authors: | Hughes, T.E.T, Rosario, J.S.D, Kapoor, A, Yazici, A.T, Fluck, E.C, Filizola, M, Rohacs, T, Moiseenkova-Bell, V.Y. | Deposit date: | 2019-06-13 | Release date: | 2019-11-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structure-based characterization of novel TRPV5 inhibitors. Elife, 8, 2019
|
|
6PBE
| ZINC17988990-bound TRPV5 in nanodiscs | Descriptor: | (4-oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)methyl 3-(3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)propanoate, Transient receptor potential cation channel subfamily V member 5 | Authors: | Hughes, T.E.T, Rosario, J.S.D, Kapoor, A, Yazici, A.T, Fluck, E.C, Filizola, M, Rohacs, T, Moiseenkova-Bell, V.Y. | Deposit date: | 2019-06-13 | Release date: | 2019-11-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.78 Å) | Cite: | Structure-based characterization of novel TRPV5 inhibitors. Elife, 8, 2019
|
|
6PQP
| Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist BITC | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-benzylthioformamide, ... | Authors: | Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y. | Deposit date: | 2019-07-09 | Release date: | 2020-01-08 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. Neuron, 105, 2020
|
|
6PQQ
| Cryo-EM structure of human TRPA1 C621S mutant in the apo state | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily A member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | Authors: | Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y. | Deposit date: | 2019-07-09 | Release date: | 2020-01-08 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.81 Å) | Cite: | Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. Neuron, 105, 2020
|
|
6PQO
| Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist JT010 | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloro-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-N-(3-methoxypropyl)acetamide, ... | Authors: | Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y. | Deposit date: | 2019-07-09 | Release date: | 2020-01-08 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (2.88 Å) | Cite: | Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. Neuron, 105, 2020
|
|
6PVQ
| |
6PY8
| Crystal structure of the RBPJ-NOTCH1-NRARP ternary complex bound to DNA | Descriptor: | DNA, Neurogenic locus notch homolog protein 1, Notch-regulated ankyrin repeat-containing protein, ... | Authors: | Jarrett, S.M, Seegar, T.C.M, Blacklow, S.C. | Deposit date: | 2019-07-29 | Release date: | 2019-08-14 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.75 Å) | Cite: | Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling. Sci.Signal., 12, 2019
|
|
6PVN
| |
6PVL
| |
6PVM
| |
6PVO
| |
8SP8
| Human TRP channel TRPV6 in cNW30 nanodiscs inhibited by tetrahydrocannabivarin (THCV) | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHLORIDE ION, ... | Authors: | Neuberger, A, Yelshanskaya, M.V, Nadezhdin, K.D, Sobolevsky, A.I. | Deposit date: | 2023-05-02 | Release date: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (2.79 Å) | Cite: | Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin. Nat Commun, 14, 2023
|
|
6PVP
| |
8T1B
| Cryo-EM structure of full-length human TRPV4 in apo state | Descriptor: | (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, SODIUM ION, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera, ... | Authors: | Nadezhdin, K.D, Talyzina, I.A, Neuberger, A, Sobolevsky, A.I. | Deposit date: | 2023-06-02 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
|
|
8T1D
| Open-state cryo-EM structure of full-length human TRPV4 in complex with agonist 4a-PDD | Descriptor: | (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera | Authors: | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | Deposit date: | 2023-06-02 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
|
|
8T1F
| Cryo-EM structure of full-length human TRPV4 in complex with antagonist HC-067047 | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-methyl-1-[3-(morpholin-4-yl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera | Authors: | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | Deposit date: | 2023-06-02 | Release date: | 2023-07-05 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
|
|
8T1C
| Cryo-EM structure of human TRPV4 ankyrin repeat domain in complex with GTPase RhoA | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Transforming protein RhoA, Transient receptor potential cation channel subfamily V member 4-Enhanced green fluorescent protein chimera | Authors: | Nadezhdin, K.D, Talyzina, I.A, Neuberger, A, Sobolevsky, A.I. | Deposit date: | 2023-06-02 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
|
|
8T1E
| Closed-state cryo-EM structure of full-length human TRPV4 in the presence of 4a-PDD | Descriptor: | (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, SODIUM ION, Transient receptor potential cation channel subfamily V member 4,Enhanced green fluorescent protein, ... | Authors: | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | Deposit date: | 2023-06-02 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
|
|
8SWI
| |
6OT2
| Structure of the TRPV3 K169A sensitized mutant in apo form at 4.1 A resolution | Descriptor: | Transient receptor potential cation channel subfamily V member 3 | Authors: | Zubcevic, L, Borschel, W.F, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | Deposit date: | 2019-05-02 | Release date: | 2019-05-22 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Regulatory switch at the cytoplasmic interface controls TRPV channel gating. Elife, 8, 2019
|
|
8SR6
| Crystal structure of legAS4 from Legionella pneumophila subsp. pneumophila with histone H3 (3-17)peptide | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Eukaryotic huntingtin interacting protein B, ... | Authors: | Xu, C, Chung, I.Y.W, Cygler, M. | Deposit date: | 2023-05-05 | Release date: | 2024-03-13 | Last modified: | 2024-09-25 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | The SET and ankyrin domains of the secreted Legionella pneumophila histone methyltransferase work together to modify host chromatin. Mbio, 14, 2023
|
|
6OT5
| Structure of the TRPV3 K169A sensitized mutant in the presence of 2-APB at 3.6 A resolution | Descriptor: | 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 3,Transient receptor potential cation channel subfamily V member 3 | Authors: | Zubcevic, L, Borschel, W.F, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | Deposit date: | 2019-05-02 | Release date: | 2019-05-22 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Regulatory switch at the cytoplasmic interface controls TRPV channel gating. Elife, 8, 2019
|
|