ZINC9155420-bound TRPV5 in nanodiscs

Summary for 6PBF

EMDB information20292 20291
DescriptorTransient receptor potential cation channel subfamily V member 5, (1S)-1-(4-oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)ethyl [(2S)-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetate (2 entities in total)
Functional Keywordstrpv5, trp channel, inhibitor, calcium channel, transport protein
Biological sourceOryctolagus cuniculus (Rabbit)
Total number of polymer chains4
Total molecular weight333508.84
Hughes, T.E.T.,Rosario, J.S.D.,Kapoor, A.,Yazici, A.T.,Fluck, E.C.,Filizola, M.,Rohacs, T.,Moiseenkova-Bell, V.Y. (deposition date: 2019-06-13, release date: 2019-11-06, Last modification date: 2020-01-08)
Primary citation
Hughes, T.E.,Del Rosario, J.S.,Kapoor, A.,Yazici, A.T.,Yudin, Y.,Fluck, E.C.,Filizola, M.,Rohacs, T.,Moiseenkova-Bell, V.Y.
Structure-based characterization of novel TRPV5 inhibitors.
Elife, 8:-, 2019
PubMed: 31647410 (PDB entries with the same primary citation)
DOI: 10.7554/eLife.49572
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers500MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
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