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3U7X	Crystal structure of the human eIF4E-4EBP1 peptide complex without cap Descriptor: Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1, SULFATE ION, ... Authors: Siddiqui, N, Tempel, W, Nedyalkova, L, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Borden, K.L.B, Park, H, Structural Genomics Consortium (SGC) Deposit date: 2011-10-14 Release date: 2011-11-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural Insights into the Allosteric Effects of 4EBP1 on the Eukaryotic Translation Initiation Factor eIF4E. J.Mol.Biol., 415, 2012
8CL1	HIV-1 mature capsid hexamer from CA-IP6 CLPs, bound to CPSF6 peptide. Descriptor: Cleavage and polyadenylation specificity factor subunit 6, Gag polyprotein Authors: Stacey, J.C.V, Briggs, J.A.G. Deposit date: 2023-02-16 Release date: 2023-04-26 Method: ELECTRON MICROSCOPY (3.35 Å) Cite: Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CL2	HIV-1 mature capsid pentamer from CA-IP6 CLPs bound to CPSF6 peptide Descriptor: Gag polyprotein Authors: Stacey, J.C.V, Briggs, J.A.G. Deposit date: 2023-02-16 Release date: 2023-04-26 Method: ELECTRON MICROSCOPY (3.45 Å) Cite: Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CKZ	HIV-1 mature capsid pentamer from CA-IP6 CLPs bound to Nup153 peptide Descriptor: Gag polyprotein Authors: Stacey, J.C.V, Briggs, J.A.G. Deposit date: 2023-02-16 Release date: 2023-04-26 Method: ELECTRON MICROSCOPY (3.07 Å) Cite: Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CL3	HIV-1 mature capsid hexamer from CA-IP6 CLPs, bound to Sec24C peptide. Descriptor: Gag polyprotein, Protein transport protein Sec24C Authors: Stacey, J.C.V, Briggs, J.A.G. Deposit date: 2023-02-16 Release date: 2023-04-26 Method: ELECTRON MICROSCOPY (3.14 Å) Cite: Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CKW	HIV-1 mature capsid pentamer from CA-IP6 CLPs Descriptor: Gag polyprotein Authors: Stacey, J.C.V, Briggs, J.A.G. Deposit date: 2023-02-16 Release date: 2023-04-26 Method: ELECTRON MICROSCOPY (3.12 Å) Cite: Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CKX	HIV-1 mature capsid hexamer next to pentamer (type I) from CA-IP6 CLPs Descriptor: Gag polyprotein Authors: Stacey, J.C.V, Briggs, J.A.G. Deposit date: 2023-02-16 Release date: 2023-04-26 Method: ELECTRON MICROSCOPY (2.97 Å) Cite: Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CL0	HIV-1 mature capsid hexamer next to pentamer (type I) from CA-IP6 CLPs bound to Nup153 peptide. Descriptor: Gag polyprotein, Nuclear pore complex protein Nup153 Authors: Stacey, J.C.V, Briggs, J.A.G. Deposit date: 2023-02-16 Release date: 2023-04-26 Method: ELECTRON MICROSCOPY (3.12 Å) Cite: Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CL4	HIV-1 mature capsid pentamer from CA-IP6 CLPs bound to Sec24C peptide Descriptor: Gag polyprotein Authors: Stacey, J.C.V, Briggs, J.A.G. Deposit date: 2023-02-16 Release date: 2023-04-26 Method: ELECTRON MICROSCOPY (3.14 Å) Cite: Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CKV	HIV-1 mature capsid hexamer from CA-IP6 CLPs Descriptor: Gag polyprotein Authors: Stacey, J.C.V, Briggs, J.A.G. Deposit date: 2023-02-16 Release date: 2023-04-26 Method: ELECTRON MICROSCOPY (2.89 Å) Cite: Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CKY	HIV-1 mature capsid hexamer from CA-IP6 CLPs, bound to Nup153 peptide Descriptor: Gag polyprotein, Nuclear pore complex protein Nup153 Authors: Stacey, J.C.V, Briggs, J.A.G. Deposit date: 2023-02-16 Release date: 2023-04-26 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
2M8L	HIV capsid dimer structure Descriptor: Capsid protein p24 Authors: Deshmukh, L, Schwieters, C.D, Grishaev, A, Clore, G, Ghirlando, R. Deposit date: 2013-05-23 Release date: 2013-11-20 Last modified: 2023-06-14 Method: SOLUTION NMR, SOLUTION SCATTERING Cite: Structure and Dynamics of Full-Length HIV-1 Capsid Protein in Solution. J.Am.Chem.Soc., 135, 2013
2OJG	Crystal structure of ERK2 in complex with N,N-dimethyl-4-(4-phenyl-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide Descriptor: Mitogen-activated protein kinase 1, N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE, SULFATE ION Authors: Xie, X, Jacobs, M.D. Deposit date: 2007-01-12 Release date: 2007-02-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors. J.Med.Chem., 50, 2007
2OJI	Crystal structure of ERK2 in complex with N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide Descriptor: Mitogen-activated protein kinase 1, N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE, SULFATE ION Authors: Xie, X, Jacobs, M.D. Deposit date: 2007-01-12 Release date: 2007-02-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors. J.Med.Chem., 50, 2007
2OJJ	Crystal structure of ERK2 in complex with (S)-N-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide Descriptor: (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE, Mitogen-activated protein kinase 1, SULFATE ION Authors: Xie, X, Jacobs, M.D. Deposit date: 2007-01-12 Release date: 2007-02-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors. J.Med.Chem., 50, 2007
2P55	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP Descriptor: 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE, ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... Authors: Ohren, J.F, Pavlovsky, A.G. Deposit date: 2007-03-14 Release date: 2007-10-02 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.8 Å) Cite: 4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase. J.Med.Chem., 50, 2007
2PWO	Crystal Structure of HIV-1 CA146 A92E Psuedo Cell Descriptor: CHLORIDE ION, Gag-Pol polyprotein (Pr160Gag-Pol) Authors: Kelly, B.N. Deposit date: 2007-05-11 Release date: 2007-09-25 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein. J.Mol.Biol., 373, 2007
2PWM	Crystal Structure of HIV-1 CA146 A92E real cell Descriptor: CHLORIDE ION, Gag-Pol polyprotein Authors: Kelly, B.N. Deposit date: 2007-05-11 Release date: 2007-09-25 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein. J.Mol.Biol., 373, 2007
2PXR	Crystal Structure of HIV-1 CA146 in the Presence of CAP-1 Descriptor: CHLORIDE ION, Gag-Pol polyprotein (Pr160Gag-Pol), ZINC ION Authors: Kelly, B.N. Deposit date: 2007-05-14 Release date: 2007-09-25 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein. J.Mol.Biol., 373, 2007
2M8N	HIV-1 capsid monomer structure Descriptor: Capsid protein p24 Authors: Deshmukh, L, Schwieters, C.D, Grishaev, A, Clore, G, Ghirlando, R. Deposit date: 2013-05-24 Release date: 2013-11-20 Last modified: 2023-06-14 Method: SOLUTION NMR, SOLUTION SCATTERING Cite: Structure and Dynamics of Full-Length HIV-1 Capsid Protein in Solution. J.Am.Chem.Soc., 135, 2013
2M8P	The structure of the W184AM185A mutant of the HIV-1 capsid protein Descriptor: Capsid protein p24 Authors: Deshmukh, L, Schwieters, C.D, Grishaev, A, Clore, G, Ghirlando, R. Deposit date: 2013-05-24 Release date: 2013-11-20 Last modified: 2023-06-14 Method: SOLUTION NMR, SOLUTION SCATTERING Cite: Structure and Dynamics of Full-Length HIV-1 Capsid Protein in Solution. J.Am.Chem.Soc., 135, 2013
7UMB	NanoBRET tracer Tram-bo bound to a KSR2-MEK1 complex Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Marsiglia, W.M, Khan, K.M, Dar, A.C. Deposit date: 2022-04-06 Release date: 2023-09-27 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (3.231 Å) Cite: Live-cell target engagement of allosteric MEKi on MEK-RAF/KSR-14-3-3 complexes. Nat.Chem.Biol., 20, 2024
3EQD	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with ATP-GS and MG2P Descriptor: CALCIUM ION, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... Authors: Fischmann, T.O. Deposit date: 2008-09-30 Release date: 2009-02-24 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry, 48, 2009
3E8N	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) complexed with a potent inhibitor RDEA119 and MgATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... Authors: Yan, S, Wang, Z.M. Deposit date: 2008-08-20 Release date: 2009-09-01 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.5 Å) Cite: RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer. Cancer Res., 69, 2009
7W5O	Crystal structure of ERK2 with an allosteric inhibitor Descriptor: (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, 13-[4-({Imidazo[1,2-a]pyridin-2-yl}methoxy)phenyl]-4,8-dioxa-12,14,16,18-tetraazatetracyclo[9.7.0.0^{3,9}.0^{12,17}]octadeca-1(11),2,9,15,17-pentaen-15-amine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Yoshida, M, Kinoshita, T. Deposit date: 2021-11-30 Release date: 2022-02-23 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Identification of a novel target site for ATP-independent ERK2 inhibitors. Biochem.Biophys.Res.Commun., 593, 2022

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