4WOV
 
 | | CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH BMS-066 AKA 2-METHOXY-N-({6-[3-METHYL-7-(METHYLAMINO)-3,5,8,10-TETRAAZATRICYCLO[7.3.0.0, 6]DODECA-1(9),2(6),4,7,11-PENTAEN-11-YL]PYRIDIN-2-YL}METHY L)ACETAMIDE | | Descriptor: | 2-methoxy-N-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamide, Non-receptor tyrosine-protein kinase TYK2, SULFATE ION | | Authors: | Muckelbauer, J.K. | | Deposit date: | 2014-10-16 | | Release date: | 2015-03-18 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.
J.Biol.Chem., 290, 2015
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7SK2
 | | Human wildtype GABA reuptake transporter 1 in complex with tiagabine, inward-open conformation | | Descriptor: | Sodium- and chloride-dependent GABA transporter 1, Tiagabine | | Authors: | Gati, C, Motiwala, Z, Aduri, N.G, Shaye, H, Han, G.W, Cherezov, V. | | Deposit date: | 2021-10-19 | | Release date: | 2022-06-08 | | Last modified: | 2022-07-06 | | Method: | ELECTRON MICROSCOPY (3.82 Å) | | Cite: | Structural basis of GABA reuptake inhibition.
Nature, 606, 2022
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5CGS
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7ZEK
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4V7A
 | | E. coli 70S-fMetVal-tRNAVal post-translocation complex (post4) | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Blau, C, Bock, L.V, Schroder, G.F, Davydov, I, Fischer, N, Stark, H, Rodnina, M.V, Vaiana, A.C, Grubmuller, H. | | Deposit date: | 2013-10-14 | | Release date: | 2014-07-09 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (9 Å) | | Cite: | Energy barriers and driving forces in tRNA translocation through the ribosome.
Nat.Struct.Mol.Biol., 20, 2013
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4V8Y
 | | Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex | | Descriptor: | 18S RIBOSOMAL RNA, 25S RIBOSOMAL RNA, 40S RIBOSOMAL PROTEIN S0-A, ... | | Authors: | Fernandez, I.S, Bai, X.C, Hussain, T, Kelley, A.C, Lorsch, J.R, Ramakrishnan, V, Scheres, S.H.W. | | Deposit date: | 2013-07-20 | | Release date: | 2014-07-09 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Molecular architecture of a eukaryotic translational initiation complex.
Science, 342, 2013
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7JNN
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7JN6
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4WV5
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4X4G
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4X7F
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4WFL
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4WKZ
 | | Complex of autonomous ScaG cohesin CohG and X-doc domains | | Descriptor: | ACETATE ION, Autonomous cohesin, CALCIUM ION, ... | | Authors: | Voronov-Goldman, M, Lamed, R, Bayer, E.A, Yaniv, O, Shimon, L.J.W. | | Deposit date: | 2014-10-05 | | Release date: | 2015-12-23 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Complex of autonomous ScaG cohesin CohG and X-doc domains
To Be Published
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4WLD
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4WO0
 | | Crystal structure of transthyretin in complex with apigenin | | Descriptor: | 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, Transthyretin | | Authors: | Zanotti, G, Cianci, M, Folli, C, Berni, R. | | Deposit date: | 2014-10-15 | | Release date: | 2015-08-05 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.339 Å) | | Cite: | Structural evidence for asymmetric ligand binding to transthyretin.
Acta Crystallogr.,Sect.D, 71, 2015
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6HUK
 | | CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with bicuculline and megabody Mb38. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit beta-3, ... | | Authors: | Masiulis, S, Desai, R, Uchanski, T, Serna Martin, I, Laverty, D, Karia, D, Malinauskas, T, Jasenko, Z, Pardon, E, Kotecha, A, Steyaert, J, Miller, K.W, Aricescu, A.R. | | Deposit date: | 2018-10-08 | | Release date: | 2019-01-02 | | Last modified: | 2022-03-30 | | Method: | ELECTRON MICROSCOPY (3.69 Å) | | Cite: | GABAAreceptor signalling mechanisms revealed by structural pharmacology.
Nature, 565, 2019
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4WQU
 | | Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G trapped by the antibiotic dityromycin | | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Lin, J, Gagnon, M.G, Steitz, T.A. | | Deposit date: | 2014-10-22 | | Release date: | 2015-01-28 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Conformational Changes of Elongation Factor G on the Ribosome during tRNA Translocation.
Cell, 160, 2015
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8HBD
 | | Cryo-EM structure of IRL1620-bound ETBR-Gi complex | | Descriptor: | Endothelin receptor type B,Endothelin receptor type B,Oplophorus-luciferin 2-monooxygenase catalytic subunit chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Yuan, Q, Ji, Y, Jiang, Y, Duan, J, Xu, H.E. | | Deposit date: | 2022-10-28 | | Release date: | 2023-03-22 | | Last modified: | 2023-10-04 | | Method: | ELECTRON MICROSCOPY (2.99 Å) | | Cite: | Structural basis of peptide recognition and activation of endothelin receptors.
Nat Commun, 14, 2023
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7EJE
 | | human RAD51 post-synaptic complex | | Descriptor: | DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA repair protein RAD51 homolog 1, ... | | Authors: | Zhao, L.Y, Xu, J.F, Wang, H.W. | | Deposit date: | 2021-04-02 | | Release date: | 2022-03-16 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.98 Å) | | Cite: | Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination.
Nucleic Acids Res., 49, 2021
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6VOX
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4WLX
 | | High pressure protein crystallography of hen egg white lysozyme at 280 MPa | | Descriptor: | CHLORIDE ION, Lysozyme C, SODIUM ION | | Authors: | Yamada, H, Nagae, T, Watanabe, N. | | Deposit date: | 2014-10-08 | | Release date: | 2015-04-08 | | Last modified: | 2020-02-05 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | High-pressure protein crystallography of hen egg-white lysozyme
Acta Crystallogr.,Sect.D, 71, 2015
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4WM3
 | | High pressure protein crystallography of hen egg white lysozyme at 710 MPa | | Descriptor: | CHLORIDE ION, Lysozyme C, SODIUM ION | | Authors: | Yamada, H, Nagae, T, Watanabe, N. | | Deposit date: | 2014-10-08 | | Release date: | 2015-04-08 | | Last modified: | 2020-02-05 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | High-pressure protein crystallography of hen egg-white lysozyme
Acta Crystallogr.,Sect.D, 71, 2015
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4X63
 | | Crystal structure of PRMT5:MEP50 with EPZ015666 and SAH | | Descriptor: | Methylosome protein 50, N-[(2S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl]-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide, Protein arginine N-methyltransferase 5, ... | | Authors: | Boriack-Sjodin, P.A. | | Deposit date: | 2014-12-06 | | Release date: | 2015-04-22 | | Last modified: | 2015-05-27 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.
Nat.Chem.Biol., 11, 2015
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4WNJ
 | | Crystal structure of Transthyretin-quercetin complex | | Descriptor: | 3,5,7,3',4'-PENTAHYDROXYFLAVONE, DIMETHYL SULFOXIDE, Transthyretin | | Authors: | Zanotti, G, Cianci, M, Berni, R, Folli, C. | | Deposit date: | 2014-10-13 | | Release date: | 2015-08-05 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.398 Å) | | Cite: | Structural evidence for asymmetric ligand binding to transthyretin.
Acta Crystallogr.,Sect.D, 71, 2015
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4WNV
 | | Human Cytochrome P450 2D6 Quinine Complex | | Descriptor: | Cytochrome P450 2D6, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Wang, A, Stout, C.D, Johnson, E.F. | | Deposit date: | 2014-10-14 | | Release date: | 2015-01-14 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding.
J.Biol.Chem., 290, 2015
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