4WNJ

Crystal structure of Transthyretin-quercetin complex

Summary for 4WNJ

DescriptorTransthyretin, DIMETHYL SULFOXIDE, 3,5,7,3',4'-PENTAHYDROXYFLAVONE, ... (4 entities in total)
Functional Keywordsamyloidosis; protein misfolding, negative cooperativity, fibrillogenesis inhibitors, transthyretin stabilizers, transport protein
Biological sourceHomo sapiens (Human)
Cellular locationSecreted P02766
Total number of polymer chains2
Total molecular weight28013.22
Authors
Zanotti, G.,Cianci, M.,Berni, R.,Folli, C. (deposition date: 2014-10-13, release date: 2015-08-05, Last modification date: 2015-08-19)
Primary citation
Cianci, M.,Folli, C.,Zonta, F.,Florio, P.,Berni, R.,Zanotti, G.
Structural evidence for asymmetric ligand binding to transthyretin.
Acta Crystallogr.,Sect.D, 71:1582-1592, 2015
PubMed: 26249340 (PDB entries with the same primary citation)
DOI: 10.1107/S1399004715010585
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.398 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.19512007.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4wnj
no rotation
Molmil generated image of 4wnj
rotated about x axis by 90°
Molmil generated image of 4wnj
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 4wnj
no rotation
Molmil generated image of 4wnj
rotated about x axis by 90°
Molmil generated image of 4wnj
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4wnj.pdb1.gz [160.08 KB])