4WV5

HEAT SHOCK PROTEIN 70 SUBSTRATE BINDING DOMAIN

Summary for 4WV5

• Entry DOI: 10.2210/pdb4wv5/pdb
• Related: 4WV7
• Descriptor: Heat shock 70 kDa protein 1A/1B, GLYCEROL (3 entities in total)
• Functional Keywords: chaperone
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : P08107
• Total number of polymer chains: 2
• Total formula weight: 33059.13

Authors

Kirby, C.,Stams, T.,Baird, J. (deposition date: 2014-11-04, release date: 2015-01-14, Last modification date: 2023-09-27)

• Primary citation: Hassan, A.Q.,Kirby, C.A.,Zhou, W.,Schuhmann, T.,Kityk, R.,Kipp, D.R.,Baird, J.,Chen, J.,Chen, Y.,Chung, F.,Hoepfner, D.,Movva, N.R.,Pagliarini, R.,Petersen, F.,Quinn, C.,Quinn, D.,Riedl, R.,Schmitt, E.K.,Schitter, A.,Stams, T.,Studer, C.,Fortin, P.D.,Mayer, M.P.,Sadlish, H.; The novolactone natural product disrupts the allosteric regulation of hsp70.; Chem.Biol., 22:87-97, 2015; PubMed: 25544045; DOI: 10.1016/j.chembiol.2014.11.007

Experimental method

X-RAY DIFFRACTION (2.04 Å)