4WV7
HEAT SHOCK PROTEIN 70 SUBSTRATE BINDING DOMAIN WITH COVALENTLY LINKED NOVOLACTONE
Summary for 4WV7
Entry DOI | 10.2210/pdb4wv7/pdb |
Descriptor | Heat shock 70 kDa protein 1A/1B, (5beta,6alpha,8alpha,14alpha)-13-ethenyl-5,6-dihydroxy-14-methylpodocarp-12-en-15-oic acid (3 entities in total) |
Functional Keywords | allosteric inhibitor, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P08107 |
Total number of polymer chains | 2 |
Total formula weight | 33635.94 |
Authors | Kirby, C.A.,Baird, J.,Stams, T. (deposition date: 2014-11-04, release date: 2015-01-14, Last modification date: 2023-09-27) |
Primary citation | Hassan, A.Q.,Kirby, C.A.,Zhou, W.,Schuhmann, T.,Kityk, R.,Kipp, D.R.,Baird, J.,Chen, J.,Chen, Y.,Chung, F.,Hoepfner, D.,Movva, N.R.,Pagliarini, R.,Petersen, F.,Quinn, C.,Quinn, D.,Riedl, R.,Schmitt, E.K.,Schitter, A.,Stams, T.,Studer, C.,Fortin, P.D.,Mayer, M.P.,Sadlish, H. The novolactone natural product disrupts the allosteric regulation of hsp70. Chem.Biol., 22:87-97, 2015 Cited by PubMed: 25544045DOI: 10.1016/j.chembiol.2014.11.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.42 Å) |
Structure validation
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