4WOV

CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH BMS-066 AKA 2-METHOXY-N-({6-[3-METHYL-7-(METHYLAMINO)-3,5,8,10-TETRAAZATRICYCLO[7.3.0.0, 6]DODECA-1(9),2(6),4,7,11-PENTAEN-11-YL]PYRIDIN-2-YL}METHY L)ACETAMIDE

Summary for 4WOV

• Entry DOI: 10.2210/pdb4wov/pdb
• Descriptor: Non-receptor tyrosine-protein kinase TYK2, 2-methoxy-N-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: kinase, tyk2, pseudokinase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 72237.46

Authors

Muckelbauer, J.K. (deposition date: 2014-10-16, release date: 2015-03-18, Last modification date: 2023-12-27)

• Primary citation: Tokarski, J.S.,Zupa-Fernandez, A.,Tredup, J.A.,Pike, K.,Chang, C.,Xie, D.,Cheng, L.,Pedicord, D.,Muckelbauer, J.,Johnson, S.R.,Wu, S.,Edavettal, S.C.,Hong, Y.,Witmer, M.R.,Elkin, L.L.,Blat, Y.,Pitts, W.J.,Weinstein, D.S.,Burke, J.R.; Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.; J.Biol.Chem., 290:11061-11074, 2015; PubMed: 25762719; DOI: 10.1074/jbc.M114.619502

Experimental method

X-RAY DIFFRACTION (1.8 Å)