4WOV
CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH BMS-066 AKA 2-METHOXY-N-({6-[3-METHYL-7-(METHYLAMINO)-3,5,8,10-TETRAAZATRICYCLO[7.3.0.0, 6]DODECA-1(9),2(6),4,7,11-PENTAEN-11-YL]PYRIDIN-2-YL}METHY L)ACETAMIDE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue 3SM A 901 |
| Chain | Residue |
| A | LEU595 |
| A | PRO694 |
| A | VAL697 |
| A | ARG738 |
| A | LEU741 |
| A | HOH1107 |
| A | GLY596 |
| A | GLN597 |
| A | VAL640 |
| A | GLU688 |
| A | TYR689 |
| A | VAL690 |
| A | GLU691 |
| A | GLY693 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 902 |
| Chain | Residue |
| A | HIS825 |
| A | ARG829 |
| A | HIS831 |
| B | PRO814 |
| B | LEU815 |
| B | ARG818 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 903 |
| Chain | Residue |
| A | GLY598 |
| A | THR599 |
| A | THR601 |
| A | ASN734 |
| A | ASN739 |
| A | PRO760 |
| A | GLY761 |
| A | HOH1033 |
| A | HOH1152 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for residue 3SM B 901 |
| Chain | Residue |
| B | LEU595 |
| B | GLY596 |
| B | GLN597 |
| B | VAL640 |
| B | GLU688 |
| B | TYR689 |
| B | VAL690 |
| B | GLU691 |
| B | GLY693 |
| B | PRO694 |
| B | VAL697 |
| B | ARG738 |
| B | LEU741 |
| B | HOH1097 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 902 |
| Chain | Residue |
| A | PRO814 |
| A | LEU815 |
| A | ARG818 |
| B | HIS825 |
| B | ARG829 |
| B | HIS831 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 903 |
| Chain | Residue |
| B | GLY598 |
| B | THR599 |
| B | THR601 |
| B | ASN734 |
| B | ASN739 |
| B | PRO760 |
| B | GLY761 |
| B | HOH1040 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 904 |
| Chain | Residue |
| A | ARG744 |
| B | HIS692 |
| B | ARG744 |
| B | LEU745 |
| B | GLY746 |
| B | HOH1004 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9R117","evidenceCode":"ECO:0000250"}]} |
