PDB: 53102 resultsInfo pagesStatus searchChemie searchBIRD

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4URI	Crystal structure of chitinase-like agglutinin RobpsCRA from Robinia pseudoacacia Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHITINASE-RELATED AGGLUTININ, CHLORIDE ION, ... Authors: Sulzenbacher, G, Roig-Zamboni, V, Peumans, W.J, Henrissat, B, van Damme, E.J.M, Bourne, Y. Deposit date: 2014-06-30 Release date: 2015-03-11 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structural Basis for Carbohydrate Binding Properties of a Plant Chitinase-Like Agglutinin with Conserved Catalytic Machinery. J.Struct.Biol., 190, 2015
2L6U	Solution NMR Structure of Med25(391-543) Comprising the Activator-Interacting Domain (ACID) of Human Mediator Subuniti 25. Northeast Structural Genomics Consortium Target HR6188A Descriptor: Mediator complex subunit MED25 Authors: Eletsky, A, Ryuechan, W.T, Sukumaran, D.K, Shastry, R, Ciccosanti, C, Janjua, H, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) Deposit date: 2010-11-24 Release date: 2011-01-12 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Solution NMR structure of MED25(391-543) comprising the activator-interacting domain (ACID) of human mediator subunit 25. J.Struct.Funct.Genom., 12, 2011
8IWR	hSPCA1 in the CaE1-ATP state Descriptor: CALCIUM ION, Calcium-transporting ATPase type 2C member 1, MAGNESIUM ION, ... Authors: Liu, Z.M, Wu, M.Q, Wu, C. Deposit date: 2023-03-31 Release date: 2023-12-27 Method: ELECTRON MICROSCOPY (3.52 Å) Cite: Structure and transport mechanism of the human calcium pump SPCA1. Cell Res., 33, 2023
6UCL	Transcription factor deltaFosB bZIP domain self-assembly, type-I crystal Descriptor: CHLORIDE ION, Protein fosB Authors: Yin, Z, Machius, M, Rudenko, G. Deposit date: 2019-09-16 Release date: 2020-01-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.207 Å) Cite: Self-assembly of the bZIP transcription factor Delta FosB. Curr Res Struct Biol, 2, 2020
4V2S	Crystal structure of Hfq in complex with the sRNA RydC Descriptor: RNA-BINDING PROTEIN HFQ, RYDC Authors: Dimastrogiovanni, D, Frohlich, K.S, Bruce, H.A, Bandyra, K.J, Hohensee, S, Vogel, J, Luisi, B.F. Deposit date: 2014-10-14 Release date: 2015-01-14 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.48 Å) Cite: Recognition of the small regulatory RNA RydC by the bacterial Hfq protein. Elife, 3, 2014
8IWP	hSPCA1 in the CaE1 state Descriptor: CALCIUM ION, Calcium-transporting ATPase type 2C member 1 Authors: Liu, Z.M, Wu, M.Q, Wu, C. Deposit date: 2023-03-30 Release date: 2023-12-27 Method: ELECTRON MICROSCOPY (3.59 Å) Cite: Structure and transport mechanism of the human calcium pump SPCA1. Cell Res., 33, 2023
7OZB	FGFR1 kinase domain (residues 458-765) with mutations C488A, C584S in complex with 38. Descriptor: 1,2-ETHANEDIOL, 4-[3-(4-piperazin-4-ium-1-ylphenyl)-1H-indazol-6-yl]phenol, Fibroblast growth factor receptor 1, ... Authors: Trinh, C.H, Turner, L.D, Fishwick, C.W.G. Deposit date: 2021-06-27 Release date: 2021-12-01 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.71 Å) Cite: From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor. J.Med.Chem., 65, 2022
6UGH	Cryo-EM structure of the apo form of human PRMT5:MEP50 complex at a resolution of 3.4 angstrom Descriptor: Methylosome protein 50, Protein arginine N-methyltransferase 5 Authors: Zhou, W, Yadav, G.P, Jiang, Q.-X, Li, C. Deposit date: 2019-09-26 Release date: 2020-12-09 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: A 3.4-angstrom cryo-EM structure of the apo form of hu-man PRMT5:MEP50 complex reveals sequential catalysis of symmetric methyl transfer To Be Published
6UCV	Cryo-EM structure of the mitochondrial TOM complex from yeast (tetramer) Descriptor: 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Mitochondrial import receptor subunit TOM22, Mitochondrial import receptor subunit TOM40, ... Authors: Park, E, Tucker, K. Deposit date: 2019-09-17 Release date: 2019-11-06 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Cryo-EM structure of the mitochondrial protein-import channel TOM complex at near-atomic resolution. Nat.Struct.Mol.Biol., 26, 2019
7XD6	The Tet-S2 state with a pseudoknotted 4-way junction of wild-type Tetrahymena group I intron with 30nt 3'/5'-exon Descriptor: MAGNESIUM ION, SPERMIDINE, The Tet-S2 state with a pseudoknotted 4-way junction molecule of co-transcriptional folded wild-type Tetrahymena group I intron with 30nt 3'/5'-exon (5'-exon), ... Authors: Luo, B, Zhang, C, Ling, X, Mukherjee, S, Jia, G, Xie, J, Jia, X, Liu, L, Baulin, E.F, Luo, Y, Jiang, L, Dong, H, Wei, X, Bujnicki, J.M, Su, Z. Deposit date: 2022-03-26 Release date: 2023-04-05 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (2.84 Å) Cite: Cryo-EM reveals dynamics of Tetrahymena group I intron self-splicing Nat Catal, 2023
7OJN	Lassa virus L protein in an elongation conformation [ELONGATION] Descriptor: 3' RNA, 5' RNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ... Authors: Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. Deposit date: 2021-05-16 Release date: 2021-12-01 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (2.92 Å) Cite: Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
7R1C	Cryo-EM structure of Bacillus megaterium gas vesicles Descriptor: Gas vesicle structural protein Authors: Huber, S.T, Evers, W, Jakobi, A.J. Deposit date: 2022-02-02 Release date: 2022-06-15 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Cryo-EM structure of gas vesicles for buoyancy-controlled motility. Cell, 186, 2023
7OZF	FGFR1 kinase domain (residues 458-765) with mutations C488A, C584S in complex with 19. Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Fibroblast growth factor receptor 1, ... Authors: Trinh, C.H, Turner, L.D, Fishwick, C.W.G. Deposit date: 2021-06-28 Release date: 2021-12-01 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.82 Å) Cite: From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor. J.Med.Chem., 65, 2022
7OZY	FGFR2 kinase domain (residues 461-763) in complex with 38. Descriptor: 1,2-ETHANEDIOL, 4-[3-(4-piperazin-4-ium-1-ylphenyl)-1H-indazol-6-yl]phenol, Fibroblast growth factor receptor 2, ... Authors: Trinh, C.H, Turner, L.D, Fishwick, C.W.G. Deposit date: 2021-06-29 Release date: 2021-12-01 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.28 Å) Cite: From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor. J.Med.Chem., 65, 2022
5B81	Solution NMR structure of a 16-mer DNA duplex containing quadruple GC mismatches showing staggered base pairing, and consequent rescue of canonical double helical characteristics Descriptor: DNA (5'-D(*CP*GP*CP*GP*TP*AP*CP*GP*CP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(*GP*CP*GP*CP*AP*TP*GP*CP*GP*CP*TP*AP*CP*GP*CP*G)-3') Authors: De, M, Chatterjee, S. Deposit date: 2016-06-11 Release date: 2016-06-29 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Solution NMR structure of a 16-mer DNA duplex containing quadruple GC mismatches showing staggered base pairing, and consequent rescue of canonical double helical characteristics To Be Published
8JGF	CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22 Descriptor: BAM8-22, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Sun, J.P, Xu, H.E, Yang, F, Liu, Z.M, Guo, L.L, Zhang, Y.M, Fang, G.X, Tie, L, Zhuang, Y.M, Xue, C.Y. Deposit date: 2023-05-20 Release date: 2024-01-10 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nat Commun, 14, 2023
4URZ	The crystal structure of H-Ras and SOS in complex with ligands Descriptor: 1-[(4-aminophenyl)sulfonyl]piperidin-2-one, GTPASE HRAS, SON OF SEVENLESS HOMOLOG 1 Authors: Winter, J.J.G, Anderson, M, Blades, K, Brassington, C, Breeze, A.L, Chresta, C, Embrey, K, Fairley, G, Faulder, P, Finlay, M.R.V, Kettle, J.G, Nowak, T, Overman, R, Patel, S.J, Perkins, P, Spadola, L, Tart, J, Tucker, J, Wrigley, G. Deposit date: 2014-07-02 Release date: 2015-03-04 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation. J.Med.Chem., 58, 2015
7OJJ	Lassa virus L protein with endonuclease and C-terminal domains in close proximity [MID-LINK] Descriptor: MAGNESIUM ION, RNA-directed RNA polymerase L, ZINC ION Authors: Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. Deposit date: 2021-05-16 Release date: 2021-12-01 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
4UVL	Crystal structure of human tankyrase 2 in complex with 5-amino-1,2- dihydroisoquinolin-1-one Descriptor: 5-aminoisoquinolin-1(4H)-one, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... Authors: Narwal, M, Haikarainen, T, Lehtio, L. Deposit date: 2014-08-07 Release date: 2015-07-29 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2 Å) Cite: Exploration of the Nicotinamide-Binding Site of the Tankyrases, Identifying 3-Arylisoquinolin-1-Ones as Potent and Selective Inhibitors in Vitro. Bioorg.Med.Chem., 23, 2015
7XF2	Cry-EM structure of vp51 in white spot syndrome virus capsid Descriptor: Capsid protein Authors: Shan, H, Shen, Q.T. Deposit date: 2022-03-31 Release date: 2023-04-05 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.73 Å) Cite: structure of vp51 in white spot syndrome virus capsid To Be Published
7OJL	Lassa virus L protein in a pre-initiation conformation [PREINITIATION] Descriptor: 3' RNA, 5' RNA, MANGANESE (II) ION, ... Authors: Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. Deposit date: 2021-05-16 Release date: 2021-12-01 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity. Nat Commun, 12, 2021
8J4U	Structure of HerA-Sir2 complex from Escherichia coli Nezha system Descriptor: MAGNESIUM ION, Nucleoside triphosphate hydrolase, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... Authors: Chen, Q, Yu, Y. Deposit date: 2023-04-20 Release date: 2024-01-03 Method: ELECTRON MICROSCOPY (2.97 Å) Cite: Multiple enzymatic activities of a Sir2-HerA system cooperate for anti-phage defense. Mol.Cell, 83, 2023
7OTT	Metabolon-embedded pyruvate dehydrogenase complex E2 core at near-atomic resolution Descriptor: Acetyltransferase component of pyruvate dehydrogenase complex Authors: Tueting, C, Kastritis, P.L. Deposit date: 2021-06-10 Release date: 2021-12-01 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.84 Å) Cite: Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction. Nat Commun, 12, 2021
4UVT	Crystal structure of human tankyrase 2 in complex with 5-amino-4- methyl-1,2-dihydroisoquinolin-1-one Descriptor: 5-amino-4-methylisoquinolin-1(2H)-one, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... Authors: Narwal, M, Haikarainen, T, Lehtio, L. Deposit date: 2014-08-08 Release date: 2015-07-29 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Exploration of the Nicotinamide-Binding Site of the Tankyrases, Identifying 3-Arylisoquinolin-1-Ones as Potent and Selective Inhibitors in Vitro. Bioorg.Med.Chem., 23, 2015
4URX	The crystal structure of H-Ras and SOS in complex with ligands Descriptor: 1-(4-bromobenzyl)pyrrolidine, 6-bromo-1H-indole, FORMIC ACID, ... Authors: Winter, J.J.G, Anderson, M, Blades, K, Brassington, C, Breeze, A.L, Chresta, C, Embrey, K, Fairley, G, Faulder, P, Finlay, M.R.V, Kettle, J.G, Nowak, T, Overman, R, Patel, S.J, Perkins, P, Spadola, L, Tart, J, Tucker, J, Wrigley, G. Deposit date: 2014-07-02 Release date: 2015-03-04 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.49 Å) Cite: Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation. J.Med.Chem., 58, 2015

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