7OZB

FGFR1 kinase domain (residues 458-765) with mutations C488A, C584S in complex with 38.

This is a non-PDB format compatible entry.

Summary for 7OZB

• Entry DOI: 10.2210/pdb7ozb/pdb
• Descriptor: Fibroblast growth factor receptor 1, 4-[3-(4-piperazin-4-ium-1-ylphenyl)-1H-indazol-6-yl]phenol, SULFATE ION, ... (5 entities in total)
• Functional Keywords: fgfr1, inhibitor, receptor tyrosine kinase, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 71990.45

Authors

Trinh, C.H.,Turner, L.D.,Fishwick, C.W.G. (deposition date: 2021-06-27, release date: 2021-12-01, Last modification date: 2024-01-31)

• Primary citation: Turner, L.D.,Trinh, C.H.,Hubball, R.A.,Orritt, K.M.,Lin, C.C.,Burns, J.E.,Knowles, M.A.,Fishwick, C.W.G.; From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor.; J.Med.Chem., 65:1481-1504, 2022; PubMed: 34780700; DOI: 10.1021/acs.jmedchem.1c01163

Experimental method

X-RAY DIFFRACTION (1.71 Å)