7CVN
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![BU of 7cvn by Molmil](/molmil-images/mine/7cvn) | The N-arylsulfonyl-indole-2-carboxamide-based inhibitors against fructose-1,6-bisphosphatase | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, 4-(3-acetamidophenyl)-N-(4-methoxyphenyl)sulfonyl-7-nitro-1H-indole-2-carboxamide, Fructose-1,6-bisphosphatase 1 | Authors: | Wang, X, Zhou, J, Xu, B. | Deposit date: | 2020-08-26 | Release date: | 2020-09-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Design,synthesis,biological evaluation and binding mode analysis of 7-nitro-indole-N-acylarylsulfonamide-based fructose-1,6-bisphosphatase inhibitors Chinese journal of medicinal chemistry, 30, 2020
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3BNL
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1REG
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6Y7Y
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![BU of 6y7y by Molmil](/molmil-images/mine/6y7y) | Fragments KCL_771 and KCL_802 in complex with MAP kinase p38-alpha | Descriptor: | (2-azanyl-2-adamantyl)methanol, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, 6-[2,5-bis(oxidanylidene)pyrrolidin-1-yl]pyridine-3-sulfonamide, ... | Authors: | De Nicola, G.F, Nichols, C.E. | Deposit date: | 2020-03-02 | Release date: | 2020-03-11 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
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6Y7W
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![BU of 6y7w by Molmil](/molmil-images/mine/6y7w) | Fragment KCL_1337 in complex with MAP kinase p38-alpha | Descriptor: | (2~{R})-~{N}-[(2-azanyl-2-adamantyl)methyl]-4-[6-[2,5-bis(oxidanylidene)pyrrolidin-1-yl]pyridin-3-yl]sulfonyl-2-methyl-morpholine-2-carboxamide, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, CALCIUM ION, ... | Authors: | De Nicola, G.F, Nichols, C.E. | Deposit date: | 2020-03-02 | Release date: | 2020-03-11 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
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6YCU
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![BU of 6ycu by Molmil](/molmil-images/mine/6ycu) | Fragment KCL_K777 in complex with MAP kinase p38-alpha | Descriptor: | 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, 4-[2,5-bis(oxidanylidene)pyrrol-1-yl]-~{N}-propyl-benzenesulfonamide, CALCIUM ION, ... | Authors: | De Nicola, G.F, Nichols, C.E. | Deposit date: | 2020-03-19 | Release date: | 2020-04-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
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1R8B
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![BU of 1r8b by Molmil](/molmil-images/mine/1r8b) | Crystal Structures of an Archaeal Class I CCA-Adding Enzyme and Its Nucleotide | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Xiong, Y, Li, F, Wang, J, Weiner, A.M, Steitz, T.A. | Deposit date: | 2003-10-23 | Release date: | 2003-12-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes Mol.Cell, 12, 2003
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8PIX
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![BU of 8pix by Molmil](/molmil-images/mine/8pix) | Cryo EM structure of the type 3C polymorph of alpha-synuclein at low pH. | Descriptor: | Alpha-synuclein | Authors: | Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R. | Deposit date: | 2023-06-22 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.41 Å) | Cite: | On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation Elife, 2023
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3BNO
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8PJO
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![BU of 8pjo by Molmil](/molmil-images/mine/8pjo) | Cryo EM structure of the type 3D polymorph of alpha-synuclein E46K mutant at low pH. | Descriptor: | Alpha-synuclein, CHLORIDE ION | Authors: | Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R. | Deposit date: | 2023-06-23 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.31 Å) | Cite: | On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation Elife, 2023
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8PK4
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![BU of 8pk4 by Molmil](/molmil-images/mine/8pk4) | Cryo EM structure of the type 5A polymorph of alpha-synuclein. | Descriptor: | Alpha-synuclein | Authors: | Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R. | Deposit date: | 2023-06-24 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation Elife, 2023
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8PK2
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![BU of 8pk2 by Molmil](/molmil-images/mine/8pk2) | Cryo EM structure of the type 1m polymorph of alpha-synuclein | Descriptor: | Alpha-synuclein | Authors: | Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R. | Deposit date: | 2023-06-24 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation Elife, 2023
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4JF2
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1JH6
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![BU of 1jh6 by Molmil](/molmil-images/mine/1jh6) | Semi-reduced Cyclic Nucleotide Phosphodiesterase from Arabidopsis thaliana | Descriptor: | SULFATE ION, cyclic phosphodiesterase | Authors: | Hofmann, A, Grella, M, Botos, I, Filipowicz, W, Wlodawer, A. | Deposit date: | 2001-06-27 | Release date: | 2002-02-06 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structures of the semireduced and inhibitor-bound forms of cyclic nucleotide phosphodiesterase from Arabidopsis thaliana. J.Biol.Chem., 277, 2002
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3BNN
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3Q36
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3BNT
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3BNS
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4OPA
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4F8U
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![BU of 4f8u by Molmil](/molmil-images/mine/4f8u) | Crystal structure of the bacterial ribosomal decoding site in complex with sisomicin (C2 form) | Descriptor: | (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, RNA (5'-R(P*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3'), RNA (5'-R(P*UP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3') | Authors: | Kondo, J, Koganei, M, Kasahara, T. | Deposit date: | 2012-05-18 | Release date: | 2012-08-15 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure and specific binding mode of sisomicin to the bacterial ribosomal decoding site. Acs Med.Chem.Lett., 3, 2012
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3ZIN
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![BU of 3zin by Molmil](/molmil-images/mine/3zin) | Gu_alpha_helicase | Descriptor: | IMPORTIN SUBUNIT ALPHA-2, NUCLEOLAR RNA HELICASE 2 | Authors: | Chang, C.-W, Counago, R.M, Williams, S.J, Kobe, B. | Deposit date: | 2013-01-10 | Release date: | 2013-08-21 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Distinctive Conformation of Minor Site-Specific Nuclear Localization Signals Bound to Importin-Alpha Traffic, 14, 2013
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5W2M
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![BU of 5w2m by Molmil](/molmil-images/mine/5w2m) | APOBEC3F Catalytic Domain Complex with a Single-Stranded DNA | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3F, ZINC ION | Authors: | Fang, Y, Xiao, X, Li, S.-X, Wolfe, A, Chen, X.S. | Deposit date: | 2017-06-06 | Release date: | 2017-12-13 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Molecular Interactions of a DNA Modifying Enzyme APOBEC3F Catalytic Domain with a Single-Stranded DNA. J. Mol. Biol., 430, 2018
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3PQ1
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![BU of 3pq1 by Molmil](/molmil-images/mine/3pq1) | Crystal structure of human mitochondrial poly(A) polymerase (PAPD1) | Descriptor: | Poly(A) RNA polymerase | Authors: | Bai, Y, Srivastava, S.K, Chang, J.H, Tong, L. | Deposit date: | 2010-11-25 | Release date: | 2011-03-30 | Last modified: | 2017-08-02 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase. Mol.Cell, 41, 2011
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2AHO
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![BU of 2aho by Molmil](/molmil-images/mine/2aho) | Structure of the archaeal initiation factor eIF2 alpha-gamma heterodimer from Sulfolobus solfataricus complexed with GDPNP | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Translation initiation factor 2 alpha subunit, ... | Authors: | Yatime, L, Mechulam, Y, Blanquet, S, Schmitt, E. | Deposit date: | 2005-07-28 | Release date: | 2006-01-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Switch of the gamma Subunit in an Archaeal aIF2alphagamma Heterodimer Structure, 14, 2006
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3E5C
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![BU of 3e5c by Molmil](/molmil-images/mine/3e5c) | Crystal Structure of the SMK box (SAM-III) Riboswitch with SAM | Descriptor: | S-ADENOSYLMETHIONINE, SMK box (SAM-III) Riboswitch, STRONTIUM ION | Authors: | Lu, C. | Deposit date: | 2008-08-13 | Release date: | 2008-10-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Crystal structures of the SAM-III/S(MK) riboswitch reveal the SAM-dependent translation inhibition mechanism. Nat.Struct.Mol.Biol., 15, 2008
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