7X2Z
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![BU of 7x2z by Molmil](/molmil-images/mine/7x2z) | NMR solution structure of the 1:1 complex of a pyridostatin derivative (PyPDS) bound to a G-quadruplex MYT1L | Descriptor: | 4-(2-azanylethoxy)-N2,N6-bis[4-(2-pyrrolidin-1-ylethoxy)quinolin-2-yl]pyridine-2,6-dicarboxamide, G-quadruplex DNA MYT1L | Authors: | Liu, L.-Y, Mao, Z.-W, Liu, W. | Deposit date: | 2022-02-26 | Release date: | 2022-06-08 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Basis of Pyridostatin and Its Derivatives Specifically Binding to G-Quadruplexes. J.Am.Chem.Soc., 144, 2022
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1SQF
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![BU of 1sqf by Molmil](/molmil-images/mine/1sqf) | The crystal structure of E. coli Fmu binary complex with S-Adenosylmethionine at 2.1 A resolution | Descriptor: | S-ADENOSYLMETHIONINE, SUN protein | Authors: | Foster, P.G, Nunes, C.R, Greene, P, Moustakas, D, Stroud, R.M. | Deposit date: | 2004-03-18 | Release date: | 2004-05-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The First Structure of an RNA m5C Methyltransferase,
Fmu, Provides Insight into Catalytic Mechanism
and Specific Binding of RNA Substrate Structure, 11, 2003
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8AYG
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![BU of 8ayg by Molmil](/molmil-images/mine/8ayg) | |
4ZKU
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![BU of 4zku by Molmil](/molmil-images/mine/4zku) | P22 Tail Needle Gp26 crystallized at pH 10.0 | Descriptor: | CALCIUM ION, CHLORIDE ION, Tail needle protein gp26 | Authors: | Sankhala, R.S, Cingolani, G. | Deposit date: | 2015-04-30 | Release date: | 2015-06-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Plasticity of the Protein Plug That Traps Newly Packaged Genomes in Podoviridae Virions. J.Biol.Chem., 291, 2016
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1JNX
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3KCZ
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![BU of 3kcz by Molmil](/molmil-images/mine/3kcz) | Human poly(ADP-ribose) polymerase 2, catalytic fragment in complex with an inhibitor 3-aminobenzamide | Descriptor: | 3-aminobenzamide, GLYCEROL, Poly [ADP-ribose] polymerase 2 | Authors: | Karlberg, T, Schutz, P, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Kotenyova, T, Kotzsch, A, Kraulis, P, Nielsen, T.K, Moche, M, Nordlund, P, Nyman, T, Persson, C, Roos, A.K, Siponen, M.I, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Schuler, H, Structural Genomics Consortium (SGC) | Deposit date: | 2009-10-22 | Release date: | 2009-11-10 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888. Biochemistry, 49, 2010
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1M0I
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![BU of 1m0i by Molmil](/molmil-images/mine/1m0i) | Crystal Structure of Bacteriophage T7 Endonuclease I with a Wild-Type Active Site | Descriptor: | SULFATE ION, endodeoxyribonuclease I | Authors: | Hadden, J.M, Declais, A.C, Phillips, S.E, Lilley, D.M. | Deposit date: | 2002-06-13 | Release date: | 2002-12-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Metal ions bound at the active site of the junction-resolving enzyme T7 endonuclease I Embo J., 21, 2002
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4DHI
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![BU of 4dhi by Molmil](/molmil-images/mine/4dhi) | Structure of C. elegans OTUB1 bound to human UBC13 | Descriptor: | Ubiquitin thioesterase otubain-like, Ubiquitin-conjugating enzyme E2 N | Authors: | Wiener, R, Zhang, X, Wang, T, Wolberger, C. | Deposit date: | 2012-01-27 | Release date: | 2012-02-22 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The mechanism of OTUB1-mediated inhibition of ubiquitination. Nature, 483, 2012
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3L11
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![BU of 3l11 by Molmil](/molmil-images/mine/3l11) | Crystal Structure of the Ring Domain of RNF168 | Descriptor: | E3 ubiquitin-protein ligase RNF168, MALONATE ION, ZINC ION | Authors: | Neculai, D, Yermekbayeva, L, Crombet, L, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2009-12-10 | Release date: | 2010-01-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation. J.Biol.Chem., 287, 2012
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1M0D
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![BU of 1m0d by Molmil](/molmil-images/mine/1m0d) | Crystal Structure of Bacteriophage T7 Endonuclease I with a Wild-Type Active Site and Bound Manganese Ions | Descriptor: | Endodeoxyribonuclease I, MANGANESE (II) ION, SULFATE ION | Authors: | Hadden, J.M, Declais, A.C, Phillips, S.E, Lilley, D.M. | Deposit date: | 2002-06-12 | Release date: | 2002-07-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Metal ions bound at the active site of the junction-resolving enzyme T7 endonuclease I. EMBO J., 21, 2002
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1SVL
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![BU of 1svl by Molmil](/molmil-images/mine/1svl) | Co-crystal structure of SV40 large T antigen helicase domain and ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ZINC ION, ... | Authors: | Gai, D, Zhao, R, Finkielstein, C.V, Chen, X.S. | Deposit date: | 2004-03-29 | Release date: | 2004-10-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen. Cell(Cambridge,Mass.), 119, 2004
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6OD1
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![BU of 6od1 by Molmil](/molmil-images/mine/6od1) | IraD-bound to RssB D58P variant | Descriptor: | Anti-adapter protein IraD, Regulator of RpoS | Authors: | Deaconescu, A.M, Dorich, V. | Deposit date: | 2019-03-25 | Release date: | 2019-04-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for inhibition of a response regulator of sigmaSstability by a ClpXP antiadaptor. Genes Dev., 33, 2019
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6OLA
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![BU of 6ola by Molmil](/molmil-images/mine/6ola) | Structure of the PCV2d virus-like particle | Descriptor: | Capsid protein, DNA (5'-D(P*CP*CP*GP*G)-3') | Authors: | Khayat, R, Wen, K, Alimova, A, Galarza, J, Gottlieb, P. | Deposit date: | 2019-04-16 | Release date: | 2019-09-25 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural characterization of the PCV2d virus-like particle at 3.3 angstrom resolution reveals differences to PCV2a and PCV2b capsids, a tetranucleotide, and an N-terminus near the icosahedral 3-fold axes. Virology, 537, 2019
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1SDO
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![BU of 1sdo by Molmil](/molmil-images/mine/1sdo) | Crystal Structure of Restriction Endonuclease BstYI | Descriptor: | BstYI | Authors: | Townson, S.A, Samuelson, J.C, Vanamee, E.S, Edwards, T.A, Escalante, C.R, Xu, S.Y, Aggarwal, A.K. | Deposit date: | 2004-02-13 | Release date: | 2004-05-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal Structure of BstYI at 1.85 A Resolution: A Thermophilic Restriction Endonuclease with Overlapping Specificities to BamHI and BglII J.Mol.Biol., 338, 2004
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1J6S
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![BU of 1j6s by Molmil](/molmil-images/mine/1j6s) | Crystal Structure of an RNA Tetraplex (UGAGGU)4 with A-tetrads, G-tetrads, U-tetrads and G-U octads | Descriptor: | 5'-R(*(BRUP*GP*AP*GP*GP*U)-3', BARIUM ION, SODIUM ION | Authors: | Pan, B, Xiong, Y, Shi, K, Deng, J, Sundaralingam, M. | Deposit date: | 2002-07-10 | Release date: | 2003-08-05 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Crystal structure of an RNA purine-rich tetraplex containing adenine tetrads:
implications for specific binding in RNA tetraplexes Structure, 11, 2003
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1SVM
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![BU of 1svm by Molmil](/molmil-images/mine/1svm) | Co-crystal structure of SV40 large T antigen helicase domain and ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ZINC ION, ... | Authors: | Gai, D, Zhao, R, Finkielstein, C.V, Chen, X.S. | Deposit date: | 2004-03-29 | Release date: | 2004-10-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen. Cell(Cambridge,Mass.), 119, 2004
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2J8K
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![BU of 2j8k by Molmil](/molmil-images/mine/2j8k) | Structure of the fusion of NP275 and NP276, pentapeptide repeat proteins from Nostoc punctiforme | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, NP275-NP276, SULFATE ION | Authors: | Vetting, M.W, Hegde, S.S, Hazleton, K.Z, Blanchard, J.S. | Deposit date: | 2006-10-25 | Release date: | 2006-12-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural Characterization of the Fusion of Two Pentapeptide Repeat Proteins, Np275 and Np276, from Nostoc Punctiforme: Resurrection of an Ancestral Protein. Protein Sci., 16, 2007
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1SVO
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![BU of 1svo by Molmil](/molmil-images/mine/1svo) | Structure of SV40 large T antigen helicase domain | Descriptor: | ZINC ION, large T antigen | Authors: | Gai, D, Zhao, R, Finkielstein, C.V, Chen, X.S. | Deposit date: | 2004-03-29 | Release date: | 2004-10-19 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen. Cell(Cambridge,Mass.), 119, 2004
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1S9H
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![BU of 1s9h by Molmil](/molmil-images/mine/1s9h) | Crystal Structure of Adeno-associated virus Type 2 Rep40 | Descriptor: | Rep 40 protein | Authors: | James, J.A, Escalante, C.R, Yoon-Robarts, M, Edwards, T.A, Linden, R.M, Aggarwal, A.K. | Deposit date: | 2004-02-04 | Release date: | 2004-05-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure of the SF3 Helicase from Adeno-Associated Virus Type 2 Structure, 11, 2003
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2I8E
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![BU of 2i8e by Molmil](/molmil-images/mine/2i8e) | Structure of SSO1404, a predicted DNA repair-associated protein from Sulfolobus solfataricus P2 | Descriptor: | Hypothetical protein, IODIDE ION | Authors: | Wang, S, Zimmerman, M.D, Kudritska, M, Chruszcz, M, Savchenko, A, Edwards, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2006-09-01 | Release date: | 2006-09-26 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats. J.Biol.Chem., 283, 2008
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5CMX
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![BU of 5cmx by Molmil](/molmil-images/mine/5cmx) | X-ray structure of the complex between human alpha thrombin and a duplex/quadruplex 31-mer DNA aptamer | Descriptor: | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, POTASSIUM ION, RE31, ... | Authors: | Russo Krauss, I, Pica, A, Napolitano, V, Sica, F. | Deposit date: | 2015-07-17 | Release date: | 2016-01-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Different duplex/quadruplex junctions determine the properties of anti-thrombin aptamers with mixed folding. Nucleic Acids Res., 44, 2016
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8CT5
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8CT7
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![BU of 8ct7 by Molmil](/molmil-images/mine/8ct7) | Catalytic Core Domain of HIV-1 Integrase (F185K) bound with BI-224436 | Descriptor: | (2S)-tert-butoxy[4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl]acetic acid, 1,2-ETHANEDIOL, Integrase, ... | Authors: | Gupta, K, Van Duyne, G.D, Eilers, G, Bushman, F.D. | Deposit date: | 2022-05-13 | Release date: | 2023-02-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 angstrom resolution: Routes to inhibitor optimization. Plos Pathog., 19, 2023
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6QBT
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8D78
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![BU of 8d78 by Molmil](/molmil-images/mine/8d78) | |