7X2Z

NMR solution structure of the 1:1 complex of a pyridostatin derivative (PyPDS) bound to a G-quadruplex MYT1L

Summary for 7X2Z

• Entry DOI: 10.2210/pdb7x2z/pdb
• Descriptor: G-quadruplex DNA MYT1L, 4-(2-azanylethoxy)-N2,N6-bis[4-(2-pyrrolidin-1-ylethoxy)quinolin-2-yl]pyridine-2,6-dicarboxamide (2 entities in total)
• Functional Keywords: g-quadruplex, complex, dna
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 9921.72

Authors

Liu, L.-Y.,Mao, Z.-W.,Liu, W. (deposition date: 2022-02-26, release date: 2022-06-08, Last modification date: 2024-05-15)

• Primary citation: Liu, L.-Y.,Ma, T.Z.,Zeng, Y.L.,Liu, W.,Mao, Z.-W.; Structural Basis of Pyridostatin and Its Derivatives Specifically Binding to G-Quadruplexes.; J.Am.Chem.Soc., 144:11878-11887, 2022; PubMed: 35749293; DOI: 10.1021/jacs.2c04775

Experimental method

SOLUTION NMR