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3KZ8
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Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 3)
Descriptor: Cellular tumor antigen p53, DNA (5'-D(*TP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*C)-3'), IODIDE ION, ...
Authors:Rozenberg, H, Suad, O, Shakked, Z.
Deposit date:2009-12-08
Release date:2010-03-31
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs
Nat.Struct.Mol.Biol., 17, 2010
4Q2K
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BU of 4q2k by Molmil
Bovine alpha chymotrypsin bound to a cyclic peptide inhibitor, 5b
Descriptor: (11S)-4,9-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-17,22-dioxa-10,30-diazatetracyclo[21.2.2.2~13,16~.1~5,8~]triaconta-1(25),5,7,13,15,23,26,28-octaene-11-carboxamide, Chymotrypsinogen A
Authors:Chan, H.Y, Bruning, J.B, Abell, A.D.
Deposit date:2014-04-09
Release date:2014-07-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Macrocyclic protease inhibitors with reduced peptide character.
Angew.Chem.Int.Ed.Engl., 53, 2014
7XZZ
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BU of 7xzz by Molmil
Cryo-EM structure of the nucleosome in complex with p53
Descriptor: Cellular tumor antigen p53, DNA (169-MER), Histone H2A type 1-B/E, ...
Authors:Nishimura, M, Nozawa, K, Takizawa, Y, Kurumizaka, H.
Deposit date:2022-06-03
Release date:2022-10-12
Last modified:2023-02-15
Method:ELECTRON MICROSCOPY (4.07 Å)
Cite:Structural basis for p53 binding to its nucleosomal target DNA sequence.
Pnas Nexus, 1, 2022
7XZX
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BU of 7xzx by Molmil
Cryo-EM structure of the nucleosome in complex with p53 DNA-binding domain
Descriptor: Cellular tumor antigen p53, DNA (193-MER), Histone H2A type 1-B/E, ...
Authors:Nishimura, M, Nozawa, K, Takizawa, Y, Kurumizaka, H.
Deposit date:2022-06-03
Release date:2022-10-12
Last modified:2023-02-15
Method:ELECTRON MICROSCOPY (4.53 Å)
Cite:Structural basis for p53 binding to its nucleosomal target DNA sequence.
Pnas Nexus, 1, 2022
7YGI
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BU of 7ygi by Molmil
Crystal structure of p53 DBD domain in complex with azurin
Descriptor: Azurin, Cellular tumor antigen p53, PHOSPHATE ION, ...
Authors:Jiang, W.X, Zuo, J.Q, Hu, J.J, Chen, X.Q, Ma, L.X, Liu, Z, Xing, Q.
Deposit date:2022-07-11
Release date:2023-02-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of bacterial effector protein azurin targeting tumor suppressor p53 and inhibiting its ubiquitination.
Commun Biol, 6, 2023
4QO1
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BU of 4qo1 by Molmil
p53 DNA binding domain in complex with Nb139
Descriptor: Cellular tumor antigen p53, Nb139 Nanobody against the DNA-binding domain of p53, ZINC ION
Authors:De Gieter, S, Bethuyne, J, Gettemans, J, Garcia-Pino, A, Loris, R.
Deposit date:2014-06-19
Release date:2014-10-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.924 Å)
Cite:A nanobody modulates the p53 transcriptional program without perturbing its functional architecture.
Nucleic Acids Res., 42, 2014
5XZC
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BU of 5xzc by Molmil
Cryo-EM structure of p300-p53 protein complex
Descriptor: Cellular tumor antigen p53, Histone acetyltransferase p300
Authors:Ghosh, R, Roy, S, Sengupta, J.
Deposit date:2017-07-12
Release date:2019-01-23
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (10.7 Å)
Cite:Tumor suppressor p53-mediated structural reorganization of the transcriptional coactivator p300.
Biochemistry, 2019
3KMD
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BU of 3kmd by Molmil
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer
Descriptor: 5'-D(*GP*GP*GP*CP*AP*TP*GP*CP*CP*TP*AP*GP*GP*CP*AP*TP*GP*CP*C)-3', Cellular tumor antigen p53, ZINC ION
Authors:Chen, Y, Dey, R, Chen, L.
Deposit date:2009-11-10
Release date:2010-02-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
Structure, 18, 2010
1YCS
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BU of 1ycs by Molmil
P53-53BP2 COMPLEX
Descriptor: 53BP2, P53, ZINC ION
Authors:Gorina, S, Pavletich, N.P.
Deposit date:1996-09-30
Release date:1997-11-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2.
Science, 274, 1996
1CGI
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BU of 1cgi by Molmil
THREE-DIMENSIONAL STRUCTURE OF THE COMPLEXES BETWEEN BOVINE CHYMOTRYPSINOGEN*A AND TWO RECOMBINANT VARIANTS OF HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL-TYPE)
Descriptor: ALPHA-CHYMOTRYPSINOGEN, PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL TYPE) VARIANT 3
Authors:Hecht, H.J, Szardenings, M, Collins, J, Schomburg, D.
Deposit date:1991-10-08
Release date:1993-10-31
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Three-dimensional structure of the complexes between bovine chymotrypsinogen A and two recombinant variants of human pancreatic secretory trypsin inhibitor (Kazal-type).
J.Mol.Biol., 220, 1991
1CGJ
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BU of 1cgj by Molmil
THREE-DIMENSIONAL STRUCTURE OF THE COMPLEXES BETWEEN BOVINE CHYMOTRYPSINOGEN*A AND TWO RECOMBINANT VARIANTS OF HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL-TYPE)
Descriptor: ALPHA-CHYMOTRYPSINOGEN, PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL TYPE) VARIANT 4
Authors:Hecht, H.J, Szardenings, M, Collins, J, Schomburg, D.
Deposit date:1991-10-08
Release date:1993-10-31
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Three-dimensional structure of the complexes between bovine chymotrypsinogen A and two recombinant variants of human pancreatic secretory trypsin inhibitor (Kazal-type).
J.Mol.Biol., 220, 1991
1DLK
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BU of 1dlk by Molmil
CRYSTAL STRUCTURE ANALYSIS OF DELTA-CHYMOTRYPSIN BOUND TO A PEPTIDYL CHLOROMETHYL KETONE INHIBITOR
Descriptor: CHLORIDE ION, Thrombin heavy chain, Thrombin light chain, ...
Authors:Mac Sweeney, A, Birrane, G, Walsh, M.A, O'Connell, T, Malthouse, J.P.G.
Deposit date:1999-12-10
Release date:2000-05-03
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal structure of delta-chymotrypsin bound to a peptidyl chloromethyl ketone inhibitor.
Acta Crystallogr.,Sect.D, 56, 2000
6XJA
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BU of 6xja by Molmil
Streptococcus Pneumoniae IgA1 Protease with IgA1 substrate
Descriptor: Immunoglobulin A1 protease, Immunoglobulin alpha-1 heavy chain, Immunoglobulin alpha-1 light chain, ...
Authors:Eisenmesser, E.Z, Zheng, H.
Deposit date:2020-06-23
Release date:2021-01-20
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease.
Nat Commun, 11, 2020
8E7B
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BU of 8e7b by Molmil
Crystal structure of the p53 (Y107H) core domain monoclinic P form
Descriptor: Cellular tumor antigen p53, ZINC ION
Authors:Lovell, S, Liu, L, Battaile, K.P, Miller, S, Karanicolas, J.
Deposit date:2022-08-23
Release date:2023-05-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.
Cancer Discov, 13, 2023
8E7A
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BU of 8e7a by Molmil
Crystal structure of the p53 (Y107H) core domain orthorhombic P form
Descriptor: Cellular tumor antigen p53, ZINC ION
Authors:Lovell, S, Liu, L, Battaile, K.P, Miller, S, Karanicolas, J.
Deposit date:2022-08-23
Release date:2023-05-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.
Cancer Discov, 13, 2023
6XRE
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BU of 6xre by Molmil
Structure of the p53/RNA polymerase II assembly
Descriptor: Cellular tumor antigen p53, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11-a, ...
Authors:Liou, S.-H, Singh, S, Singer, R.H, Coleman, R.A, Liu, W.
Deposit date:2020-07-12
Release date:2021-03-24
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structure of the p53/RNA polymerase II assembly.
Commun Biol, 4, 2021
8F2I
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BU of 8f2i by Molmil
P53 monomer structure
Descriptor: Cellular tumor antigen p53
Authors:Solares, M, Kelly, D.F.
Deposit date:2022-11-08
Release date:2022-11-23
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (5 Å)
Cite:High-Resolution Imaging of Human Cancer Proteins Using Microprocessor Materials.
Chembiochem, 23, 2022
8F2H
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BU of 8f2h by Molmil
Wild type P53 dimer structure from human cancer cells
Descriptor: Cellular tumor antigen p53
Authors:Solares, M, Kelly, D.F.
Deposit date:2022-11-08
Release date:2022-11-23
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:High-Resolution Imaging of Human Cancer Proteins Using Microprocessor Materials.
Chembiochem, 23, 2022
1EX3
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BU of 1ex3 by Molmil
CRYSTAL STRUCTURE OF BOVINE CHYMOTRYPSINOGEN A (TETRAGONAL)
Descriptor: CHYMOTRYPSINOGEN A
Authors:Pjura, P.E, Lenhoff, A.M, Leonard, S.A, Gittis, A.G.
Deposit date:2000-04-28
Release date:2000-05-17
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Protein crystallization by design: chymotrypsinogen without precipitants.
J.Mol.Biol., 300, 2000
5MCU
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BU of 5mcu by Molmil
New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LHG2)
Descriptor: 1,2-ETHANEDIOL, Cellular tumor antigen p53, DNA, ...
Authors:Golovenko, D, Rozenberg, H, Shakked, Z.
Deposit date:2016-11-10
Release date:2018-06-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins.
Structure, 26, 2018
5MCV
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BU of 5mcv by Molmil
New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LWC1)
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Cellular tumor antigen p53, ...
Authors:Golovenko, D, Rozenberg, H, Shakked, Z.
Deposit date:2016-11-10
Release date:2018-06-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins.
Structure, 26, 2018
4XR8
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BU of 4xr8 by Molmil
Crystal structure of the HPV16 E6/E6AP/p53 ternary complex at 2.25 A resolution
Descriptor: 1,2-ETHANEDIOL, Cellular tumor antigen p53, DI(HYDROXYETHYL)ETHER, ...
Authors:Martinez-Zapien, D, Ruiz, F.X, Mitschler, A, Podjarny, A, Trave, G, Zanier, K.
Deposit date:2015-01-20
Release date:2016-02-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.
Nature, 529, 2016
1T7C
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BU of 1t7c by Molmil
CRYSTAL STRUCTURE OF THE P1 GLU BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX
Descriptor: Chymotrypsin A, Pancreatic trypsin inhibitor, SULFATE ION
Authors:Czapinska, H, Helland, R, Otlewski, J, Smalas, A.O.
Deposit date:2004-05-09
Release date:2005-03-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structures of five bovine chymotrypsin complexes with P1 BPTI variants.
J.Mol.Biol., 344, 2004
1T8M
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BU of 1t8m by Molmil
CRYSTAL STRUCTURE OF THE P1 HIS BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX
Descriptor: Chymotrypsin A, Pancreatic trypsin inhibitor, SULFATE ION
Authors:Czapinska, H, Helland, R, Otlewski, J, Smalas, A.O.
Deposit date:2004-05-13
Release date:2005-03-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of five bovine chymotrypsin complexes with P1 BPTI variants.
J.Mol.Biol., 344, 2004
5MCW
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BU of 5mcw by Molmil
New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LWC2)
Descriptor: Cellular tumor antigen p53, DNA, FORMYL GROUP, ...
Authors:Golovenko, D, Rozenberg, H, Shakked, Z.
Deposit date:2016-11-10
Release date:2018-06-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.897 Å)
Cite:New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins.
Structure, 26, 2018

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