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1IQ1	CRYSTAL STRUCTURE OF THE IMPORTIN-ALPHA(44-54)-IMPORTIN-ALPHA(70-529) COMPLEX Descriptor: IMPORTIN ALPHA-2 SUBUNIT Authors: Catimel, B, Teh, T, Fontes, M.R.M, Jennings, I.G, Kobe, B. Deposit date: 2001-05-28 Release date: 2001-11-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Biophysical characterization of interactions involving importin-alpha during nuclear import. J.Biol.Chem., 276, 2001
5H43	Structural and mechanistical studies of the nuclear import by Importin-alpha Descriptor: Histone acetyltransferase KAT8, Importin subunit alpha-1 Authors: Wang, R, Li, Y. Deposit date: 2016-10-28 Release date: 2017-10-25 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural insights into the nuclear import of the histone acetyltransferase males-absent-on-the-first by importin alpha 1 Traffic, 19, 2018
5U5R	Crystal Structure and X-ray Diffraction Data Collection of Importin-alpha from Mus musculus Complexed with a PMS2 NLS Peptide Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Importin subunit alpha-1, Mismatch repair endonuclease PMS2 Authors: Barros, A.C, Takeda, A.A, Dreyer, T.R, Velazquez-Campoy, A, Kobe, B, Fontes, M.R. Deposit date: 2016-12-07 Release date: 2018-03-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.1 Å) Cite: DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway. Biochimie, 146, 2018
5GXW	Importin and NuMA complex Descriptor: Importin subunit alpha-1, Peptide from Nuclear mitotic apparatus protein 1 Authors: Chang, C.-C, Huang, T.-L, Hsia, K.-C. Deposit date: 2016-09-20 Release date: 2017-10-04 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.394 Å) Cite: Regulation of mitotic spindle assembly factor NuMA by Importin-beta J. Cell Biol., 216, 2017
5H2W	Crystal structure of the karyopherin Kap60p bound to the SUMO protease Ulp1p (150-340) Descriptor: Importin subunit alpha, Ubiquitin-like-specific protease 1 Authors: Hirano, H, Matsuura, Y. Deposit date: 2016-10-18 Release date: 2016-12-14 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structures of the Karyopherins Kap121p and Kap60p Bound to the Nuclear Pore-Targeting Domain of the SUMO Protease Ulp1p J. Mol. Biol., 429, 2017
5V5P	Structure of NLS2R of influenza A virus nucleoprotein bound to importin alpha Descriptor: Importin subunit alpha-1, Nucleoprotein Authors: Sankhala, R.S, Lokareddy, R.K, Cingolani, G. Deposit date: 2017-03-14 Release date: 2018-03-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin alpha isoforms. Sci Rep, 7, 2017
5UMZ	Structure of TNRC6A NLS in complex with importin-alpha Descriptor: GLYCEROL, Importin subunit alpha-1, TNRC6A Authors: Chaston, J, Stewart, A.G, Christie, M. Deposit date: 2017-01-30 Release date: 2017-12-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural characterisation of TNRC6A nuclear localisation signal in complex with importin-alpha. PLoS ONE, 12, 2017
5V5O	Structure of NLS2K of influenza A virus nucleoprotein bound to importin alpha Descriptor: Importin subunit alpha-1, Nucleoprotein Authors: Sankhala, R.S, Lokareddy, R.K, Cingolani, G. Deposit date: 2017-03-14 Release date: 2018-03-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.243 Å) Cite: Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin alpha isoforms. Sci Rep, 7, 2017
5U5P	Crystal Structure and X-ray Diffraction Data Collection of Importin-alpha from Mus Musculus Complexed with a MLH1 NLS Peptide Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, DNA mismatch repair protein Mlh1, Importin subunit alpha-1 Authors: Barros, A.C, Takeda, A.A, Dreyer, T.R, Velazquez-Campoy, A, Kobe, B, Fontes, M.R. Deposit date: 2016-12-07 Release date: 2018-03-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.171 Å) Cite: DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway. Biochimie, 146, 2018
1JPP	The Structure of a beta-Catenin Binding Repeat from Adenomatous Polyposis Coli (APC) in Complex with beta-Catenin Descriptor: ADENOMATOUS POLYPOSIS COLI PROTEIN, BETA-CATENIN, GLYCEROL Authors: Spink, K.E, Fridman, S.G, Weis, W.I. Deposit date: 2001-08-02 Release date: 2002-01-16 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex. EMBO J., 20, 2001
8TUQ	STL Polyomavirus LTA NLS bound to importin alpha 2 Descriptor: Importin subunit alpha-1, Large T antigen Authors: Donnelly, C.M, Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-08-17 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
8TUS	WU Polyomavirus LTA NLS bound to importin alpha 2 Descriptor: Importin subunit alpha-1, Large T antigen Authors: Donnelly, C.M, Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-08-17 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
8TUR	Merkel Cell Polyomavirus LTA bipartite NLS bound to importin alpha 2 Descriptor: Importin subunit alpha-1, Truncated large T antigen Authors: Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-08-17 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.15 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
8Y0P	Beta-Catenin in complex with peptide 301 Descriptor: B-cell CLL/lymphoma 9 protein, Catenin beta-1, PROLINE Authors: Tim, F. Deposit date: 2024-01-22 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (2.62 Å) Cite: Beta-Catenin in complex with peptide 301 To Be Published
8TUU	MW Polyomavirus LTA bipartite NLS bound to importin alpha 2 Descriptor: Importin subunit alpha-1, Large T-antigen Authors: Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-08-17 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
8TUT	Merkel Cell Polyomavirus LTA NLSct bound to importin alpha 2 Descriptor: Importin subunit alpha-1, PRO-PRO-LYS-PRO-LYS-LYS-ASN-ARG-GLU Authors: Cross, E.M, Forwood, J.K, Alvisi, G. Deposit date: 2023-08-17 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.55 Å) Cite: A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
8G8R	RelB NLS in complex with Importin alpha 2 Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Importin subunit alpha-1, Transcription factor RelB Authors: Tsimbslyuk, S, Stewart, M, Forwood, J.K. Deposit date: 2023-02-19 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (2.6 Å) Cite: monopartite p52 NLS in complex with Importin alpha 2 To Be Published
8G8S	bipartite p52 NLS in complex with Importin alpha 2 Descriptor: Importin subunit alpha-1, Nuclear factor NF-kappa-B p100 subunit isoform X1 Authors: Tsimbslyuk, S, Stewart, M, Forwood, J.K. Deposit date: 2023-02-19 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (2.1 Å) Cite: p52 bipartite NLS in complex with Importin alpha 2 To Be Published
8G8Q	RelB NLS in complex with Importin alpha 2 Descriptor: Importin subunit alpha-1, bacterial peptide, monopartite p52 NLS Authors: Tsimbslyuk, S, Stewart, M, Forwood, J.K. Deposit date: 2023-02-19 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (2.6 Å) Cite: p52 monopartite NLS in complex with Importin alpha 2 To Be Published
8GCN	CRYO-EM STRUCTURE OF IMPORTIN ALPHA1/BETA HETERODIMER Descriptor: Importin subunit alpha-1, Importin subunit beta-1 Authors: Ko, Y, Cingolani, G. Deposit date: 2023-03-02 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3.95 Å) Cite: CRYO-EM STRUCTURE OF IMPORTIN ALPHA1/BETA HETERODIMER To Be Published
1O6P	Importin Beta bound to a GLFG Nucleoporin peptide Descriptor: IMPORTIN BETA-1 SUBUNIT, SYNTHETIC GLFG PEPTIDE Authors: Bayliss, R, Stewart, M. Deposit date: 2002-10-10 Release date: 2003-04-24 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Glfg and Fxfg Nucleoporins Bind to Overlapping Sites on Importin-Beta J.Biol.Chem., 277, 2002
3QHE	Crystal structure of the complex between the armadillo repeat domain of adenomatous polyposis coli and the tyrosine-rich domain of Sam68 Descriptor: Adenomatous polyposis coli protein, KH domain-containing, RNA-binding, ... Authors: Morishita, E.C.J, Murayama, K, Kato-Murayama, M, Ishizuku-Katsura, Y, Tomabechi, Y, Terada, T, Handa, N, Shirouzu, M, Akiyama, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2011-01-25 Release date: 2011-11-02 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of sam68 Structure, 19, 2011
1O6O	Importin Beta aa1-442 bound to five FxFG repeats from yeast Nsp1p. Second crystal form Descriptor: IMPORTIN BETA-1 SUBUNIT, NUCLEOPORIN NSP1 Authors: Bayliss, R, Stewart, M. Deposit date: 2002-10-10 Release date: 2003-10-17 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Glfg and Fxfg Nucleoporins Bind to Overlapping Sites on Importin-Beta J.Biol.Chem., 277, 2002
8GSJ	APC-Asef tripeptide inhibitor Descriptor: (1R,2S)-2-phenylcyclopropanamine, 2-methylsulfanylpyrimidine-4-carbaldehyde, Adenomatous polyposis coli protein, ... Authors: Zhang, J, Wang, X.F, Song, K. Deposit date: 2022-09-06 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: APC-Asef tripeptide inhibitor To Be Published
8HKW	Crystal structure of importin-alpha3 bound to the 53BP1 nuclear localization signal Descriptor: Importin subunit alpha-3, Peptide from TP53-binding protein 1 Authors: Matsuura, Y. Deposit date: 2022-11-28 Release date: 2022-12-21 Last modified: 2023-03-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystallographic data of an importin-alpha 3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal. Data Brief, 47, 2023

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