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1EJY	MOUSE IMPORTIN ALPHA-NUCLEOPLASMIN NLS PEPTIDE COMPLEX Descriptor: IMPORTIN ALPHA, NUCLEOPLASMIN NLS PEPTIDE Authors: Fontes, M.R, Teh, T, Kobe, B. Deposit date: 2000-03-05 Release date: 2000-04-24 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha. J.Mol.Biol., 297, 2000
6MJL	Crystal structure of ChREBP NLS peptide bound to importin alpha. Descriptor: ChREBP Peptide ASN-TYR-TRP-LYS-ARG-ARG-ILE-GLU-VAL, Importin subunit alpha-1 Authors: Jung, H, Uyeda, K. Deposit date: 2018-09-21 Release date: 2019-09-25 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The structure of importin alpha and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP-importin alpha interactions. Biochem.J., 477, 2020
3NMX	Crystal structure of APC complexed with Asef Descriptor: APC variant protein, Rho guanine nucleotide exchange factor 4 Authors: Zhang, Z, Chen, L, Gao, L, Lin, K, Wu, G. Deposit date: 2010-06-22 Release date: 2011-07-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for the recognition of Asef by adenomatous polyposis coli. Cell Res., 22, 2012
1F59	IMPORTIN-BETA-FXFG NUCLEOPORIN COMPLEX Descriptor: FXFG NUCLEOPORIN REPEATS, IMPORTIN BETA-1 Authors: Bayliss, R, Littlewood, T, Stewart, M. Deposit date: 2000-06-13 Release date: 2000-08-16 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking. Cell(Cambridge,Mass.), 102, 2000
6N88	Cryo-EM structure of the Importin7:Importin beta:Histone H1.0 complex Descriptor: Histone H1.0, Importin subunit beta-1, MGC52556 protein Authors: Bilokapic, S, Ivic, N, Halic, M. Deposit date: 2018-11-28 Release date: 2019-02-27 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (6.2 Å) Cite: Fuzzy Interactions Form and Shape the Histone Transport Complex. Mol. Cell, 73, 2019
1M5N	Crystal structure of HEAT repeats (1-11) of importin b bound to the non-classical NLS(67-94) of PTHrP Descriptor: Importin beta-1 subunit, Parathyroid hormone-related protein Authors: Cingolani, G, Bednenko, J, Gillespie, M.T, Gerace, L. Deposit date: 2002-07-09 Release date: 2003-01-21 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta Mol.Cell, 10, 2002
5H2X	Crystal structure of the karyopherin Kap60p bound to the SUMO protease Ulp1p (150-172) Descriptor: Importin subunit alpha, Ubiquitin-like-specific protease 1 Authors: Hirano, H, Matsuura, Y. Deposit date: 2016-10-18 Release date: 2016-12-14 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structures of the Karyopherins Kap121p and Kap60p Bound to the Nuclear Pore-Targeting Domain of the SUMO Protease Ulp1p J. Mol. Biol., 429, 2017
5GXW	Importin and NuMA complex Descriptor: Importin subunit alpha-1, Peptide from Nuclear mitotic apparatus protein 1 Authors: Chang, C.-C, Huang, T.-L, Hsia, K.-C. Deposit date: 2016-09-20 Release date: 2017-10-04 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.394 Å) Cite: Regulation of mitotic spindle assembly factor NuMA by Importin-beta J. Cell Biol., 216, 2017
5H2W	Crystal structure of the karyopherin Kap60p bound to the SUMO protease Ulp1p (150-340) Descriptor: Importin subunit alpha, Ubiquitin-like-specific protease 1 Authors: Hirano, H, Matsuura, Y. Deposit date: 2016-10-18 Release date: 2016-12-14 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structures of the Karyopherins Kap121p and Kap60p Bound to the Nuclear Pore-Targeting Domain of the SUMO Protease Ulp1p J. Mol. Biol., 429, 2017
1O6O	Importin Beta aa1-442 bound to five FxFG repeats from yeast Nsp1p. Second crystal form Descriptor: IMPORTIN BETA-1 SUBUNIT, NUCLEOPORIN NSP1 Authors: Bayliss, R, Stewart, M. Deposit date: 2002-10-10 Release date: 2003-10-17 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Glfg and Fxfg Nucleoporins Bind to Overlapping Sites on Importin-Beta J.Biol.Chem., 277, 2002
5HUY	Structure of HCMV Small Terminase NLS bound to importin alpha Descriptor: HCMV small terminase, Importin subunit alpha-1 Authors: Sankhala, R.S, Lokareddy, R.K, Cingolani, G. Deposit date: 2016-01-28 Release date: 2016-03-16 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.979 Å) Cite: Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits. J.Biol.Chem., 291, 2016
1M1E	Beta-catenin armadillo repeat domain bound to ICAT Descriptor: Beta-catenin, ICAT Authors: Daniels, D.L, Weis, W.I. Deposit date: 2002-06-18 Release date: 2002-10-16 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: ICAT inhibits Beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. Mol.Cell, 10, 2002
5HUW	Structure of HSV-1 Large Terminase NLS bound to importin alpha Descriptor: HSV1 large terminase NLS, Importin subunit alpha-1 Authors: Sankhala, R.S, Lokareddy, R.K, Cingolani, G. Deposit date: 2016-01-27 Release date: 2016-03-09 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits. J.Biol.Chem., 291, 2016
5HHG	Mouse importin alpha: Dengue 2 NS5 C-terminal NLS peptide complex Descriptor: Importin subunit alpha-1, RNA-directed RNA polymerase NS5 Authors: Smith, K.M, Forwood, J.K. Deposit date: 2016-01-11 Release date: 2016-05-18 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production. PLoS Pathog., 12, 2016
5FC8	Mouse importin alpha: Dengue 3 NS5 C-terminal NLS peptide complex Descriptor: Importin subunit alpha-1, Nonstructural protein 5 Authors: Smith, K.M, Forwood, J.K. Deposit date: 2015-12-15 Release date: 2016-05-18 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production. PLoS Pathog., 12, 2016
5H43	Structural and mechanistical studies of the nuclear import by Importin-alpha Descriptor: Histone acetyltransferase KAT8, Importin subunit alpha-1 Authors: Wang, R, Li, Y. Deposit date: 2016-10-28 Release date: 2017-10-25 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural insights into the nuclear import of the histone acetyltransferase males-absent-on-the-first by importin alpha 1 Traffic, 19, 2018
5IZ8	Protein-protein interaction Descriptor: ACE-ALA-GLY-GLU-ALA-LEU-ALA-ASP-NH2, Adenomatous polyposis coli protein, TRIETHYLENE GLYCOL Authors: Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. Deposit date: 2016-03-25 Release date: 2017-07-05 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.06 Å) Cite: Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat. Chem. Biol., 13, 2017
1LUJ	Crystal Structure of the Beta-catenin/ICAT Complex Descriptor: Beta-catenin-interacting protein 1, Catenin beta-1 Authors: Graham, T.A, Clements, W.K, Kimelman, D, Xu, W. Deposit date: 2002-05-22 Release date: 2002-10-16 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT. Mol.Cell, 10, 2002
1PJN	Mouse Importin alpha-bipartite NLS N1N2 from Xenopus laevis phosphoprotein Complex Descriptor: Histone-binding protein N1/N2, Importin alpha-2 subunit Authors: Fontes, M.R.M, Teh, T, Jans, D, Brinkworth, R.I, Kobe, B. Deposit date: 2003-06-03 Release date: 2003-08-19 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha J.Biol.Chem., 278, 2003
1PJM	Mouse Importin alpha-bipartite NLS from human retinoblastoma protein Complex Descriptor: Importin alpha-2 subunit, Retinoblastoma-associated protein Authors: Fontes, M.R.M, Teh, T, Jans, D, Brinkworth, R.I, Kobe, B. Deposit date: 2003-06-03 Release date: 2003-08-19 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha J.Biol.Chem., 278, 2003
1O6P	Importin Beta bound to a GLFG Nucleoporin peptide Descriptor: IMPORTIN BETA-1 SUBUNIT, SYNTHETIC GLFG PEPTIDE Authors: Bayliss, R, Stewart, M. Deposit date: 2002-10-10 Release date: 2003-04-24 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Glfg and Fxfg Nucleoporins Bind to Overlapping Sites on Importin-Beta J.Biol.Chem., 277, 2002
1Q1S	Mouse Importin alpha- phosphorylated SV40 CN peptide complex Descriptor: Importin alpha-2 subunit, Large T antigen Authors: Fontes, M.R.M, Teh, T, Toth, G, John, A, Pavo, I, Jans, D.A, Kobe, B. Deposit date: 2003-07-22 Release date: 2004-03-30 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-alpha Biochem.J., 375, 2003
1Q1T	Mouse Importin alpha: non-phosphorylated SV40 CN peptide complex Descriptor: Importin alpha-2 subunit, Large T antigen Authors: Fontes, M.R.M, Teh, T, Toth, G, John, A, Pavo, I, Jans, D.A, Kobe, B. Deposit date: 2003-07-22 Release date: 2004-03-30 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-alpha Biochem.J., 375, 2003
7L04	Crystal Structure of Adeno-Associated Virus Porcine Origin capsid protein in complex with Importin-alpha 2 Descriptor: Importin subunit alpha-1, VP1 Authors: Hoad, M, Forwood, J. Deposit date: 2020-12-11 Release date: 2021-02-24 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Crystal Structure of Adeno-Associated Virus Porcine Origin capsid protein in complex with Importin-alpha 2 To Be Published
7LF4	Structure of importin a3 bound to the p50- and p65-NLSs Descriptor: Importin subunit alpha-3, Nuclear factor NF-kappa-B p105 subunit, Transcription factor p65 Authors: Florio, T.J, Lokareddy, R.K, Cingolani, G. Deposit date: 2021-01-15 Release date: 2022-01-19 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Differential recognition of canonical NF-kappa B dimers by Importin alpha 3. Nat Commun, 13, 2022

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