5OF4
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![BU of 5of4 by Molmil](/molmil-images/mine/5of4) | The cryo-EM structure of human TFIIH | Descriptor: | General transcription factor IIH subunit 2, General transcription factor IIH subunit 3, General transcription factor IIH subunit 4,p52,General transcription factor IIH subunit 4, ... | Authors: | Greber, B.J, Nguyen, T.H.D, Fang, J, Afonine, P.V, Adams, P.D, Nogales, E. | Deposit date: | 2017-07-10 | Release date: | 2017-09-13 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | The cryo-electron microscopy structure of human transcription factor IIH. Nature, 549, 2017
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2IOO
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![BU of 2ioo by Molmil](/molmil-images/mine/2ioo) | Crystal structure of the mouse p53 core domain | Descriptor: | Cellular tumor antigen p53, ZINC ION | Authors: | Ho, W.C, Luo, C, Zhao, K, Chai, X, Fitzgerald, M.X, Marmorstein, R. | Deposit date: | 2006-10-10 | Release date: | 2006-12-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | High-resolution structure of the p53 core domain: implications for binding small-molecule stabilizing compounds. Acta Crystallogr.,Sect.D, 62, 2006
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4FXH
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2IOI
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![BU of 2ioi by Molmil](/molmil-images/mine/2ioi) | Crystal structure of the mouse p53 core domain at 1.55 A | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cellular tumor antigen p53, ZINC ION | Authors: | Ho, W.C, Luo, C, Zhao, K, Chai, X, Fitzgerald, M.X, Marmorstein, R. | Deposit date: | 2006-10-10 | Release date: | 2006-12-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | High-resolution structure of the p53 core domain: implications for binding small-molecule stabilizing compounds. Acta Crystallogr.,Sect.D, 62, 2006
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2IOM
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![BU of 2iom by Molmil](/molmil-images/mine/2iom) | Mouse p53 core domain soaked with 2-propanol | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cellular tumor antigen p53, ISOPROPYL ALCOHOL, ... | Authors: | Ho, W.C, Luo, C, Zhao, K, Chai, X, Fitzgerald, M.X, Marmorstein, R. | Deposit date: | 2006-10-10 | Release date: | 2006-12-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | High-resolution structure of the p53 core domain: implications for binding small-molecule stabilizing compounds. ACTA CRYSTALLOGR.,SECT.D, 62, 2006
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5FHG
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![BU of 5fhg by Molmil](/molmil-images/mine/5fhg) | |
4FXI
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7B48
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![BU of 7b48 by Molmil](/molmil-images/mine/7b48) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to MQ: R273H-MQ (II) | Descriptor: | (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ACETATE ION, ... | Authors: | Degtjarik, O, Rozenberg, H, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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8BAH
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![BU of 8bah by Molmil](/molmil-images/mine/8bah) | Human Mre11-Nbs1 complex | Descriptor: | Double-strand break repair protein MRE11, MANGANESE (II) ION, Nibrin | Authors: | Bartho, J.D, Rotheneder, M, Stakyte, K, Lammens, K, Hopfner, K.P. | Deposit date: | 2022-10-11 | Release date: | 2023-01-11 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (4.13 Å) | Cite: | Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions. Mol.Cell, 83, 2023
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4K3Q
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![BU of 4k3q by Molmil](/molmil-images/mine/4k3q) | E. coli sliding clamp in complex with AcQLDAF | Descriptor: | (ACE)QLDAF, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Yin, Z, Oakley, A.J. | Deposit date: | 2013-04-11 | Release date: | 2013-05-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural and Thermodynamic Dissection of Linear Motif Recognition by the E. coli Sliding Clamp J.Med.Chem., 56, 2013
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7N40
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![BU of 7n40 by Molmil](/molmil-images/mine/7n40) | Crystal structure of LIN9-RbAp48-LIN37, a MuvB subcomplex | Descriptor: | Histone-binding protein RBBP4, Isoform 2 of Protein lin-9 homolog, Protein lin-37 homolog | Authors: | Asthana, A, Ramanan, P, Tripathi, S.M, Rubin, S.M. | Deposit date: | 2021-06-02 | Release date: | 2022-02-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | The MuvB complex binds and stabilizes nucleosomes downstream of the transcription start site of cell-cycle dependent genes. Nat Commun, 13, 2022
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4H0E
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![BU of 4h0e by Molmil](/molmil-images/mine/4h0e) | Crystal Structure of mutant ORR3 in complex with NTD of AraR | Descriptor: | 5'-D(*AP*AP*AP*TP*TP*TP*GP*TP*CP*CP*GP*TP*AP*CP*AP*TP*TP*TP*TP*AP*T)-3', 5'-D(*TP*AP*TP*AP*AP*AP*AP*TP*GP*TP*AP*CP*GP*GP*AP*CP*AP*AP*AP*TP*T)-3', ACETATE ION, ... | Authors: | Nair, D.T, Jain, D. | Deposit date: | 2012-09-08 | Release date: | 2013-02-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.973 Å) | Cite: | Spacing between core recognition motifs determines relative orientation of AraR monomers on bipartite operators. Nucleic Acids Res., 41, 2013
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1FC3
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2E2J
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![BU of 2e2j by Molmil](/molmil-images/mine/2e2j) | RNA polymerase II elongation complex in 5 mM Mg+2 with GMPCPP | Descriptor: | 27-MER DNA template strand, 5'-D(P*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*A)-3', 5'-R(P*AP*UP*CP*GP*AP*GP*AP*GP*G)-3', ... | Authors: | Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D. | Deposit date: | 2006-11-14 | Release date: | 2006-12-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis Cell(Cambridge,Mass.), 127, 2006
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5FGO
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![BU of 5fgo by Molmil](/molmil-images/mine/5fgo) | |
2E2H
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![BU of 2e2h by Molmil](/molmil-images/mine/2e2h) | RNA polymerase II elongation complex at 5 mM Mg2+ with GTP | Descriptor: | 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3', ... | Authors: | Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D. | Deposit date: | 2006-11-14 | Release date: | 2006-12-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.95 Å) | Cite: | Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis Cell(Cambridge,Mass.), 127, 2006
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2E2I
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![BU of 2e2i by Molmil](/molmil-images/mine/2e2i) | RNA polymerase II elongation complex in 5 mM Mg+2 with 2'-dGTP | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', ... | Authors: | Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D. | Deposit date: | 2006-11-14 | Release date: | 2006-12-19 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.41 Å) | Cite: | Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis Cell(Cambridge,Mass.), 127, 2006
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4K3R
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![BU of 4k3r by Molmil](/molmil-images/mine/4k3r) | E. coli sliding clamp in complex with AcQLDLA | Descriptor: | (ACE)QLDLA, CALCIUM ION, CHLORIDE ION, ... | Authors: | Yin, Z, Oakley, A.J. | Deposit date: | 2013-04-11 | Release date: | 2013-05-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structural and Thermodynamic Dissection of Linear Motif Recognition by the E. coli Sliding Clamp J.Med.Chem., 56, 2013
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4K3S
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![BU of 4k3s by Molmil](/molmil-images/mine/4k3s) | E. coli sliding clamp in P1 crystal space group | Descriptor: | CALCIUM ION, DNA polymerase III subunit beta, O-ACETALDEHYDYL-HEXAETHYLENE GLYCOL, ... | Authors: | Yin, Z, Oakley, A.J. | Deposit date: | 2013-04-11 | Release date: | 2013-05-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural and Thermodynamic Dissection of Linear Motif Recognition by the E. coli Sliding Clamp J.Med.Chem., 56, 2013
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7EL2
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![BU of 7el2 by Molmil](/molmil-images/mine/7el2) | |
2WV0
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![BU of 2wv0 by Molmil](/molmil-images/mine/2wv0) | Crystal structure of the GntR-HutC family member YvoA from Bacillus subtilis | Descriptor: | HTH-TYPE TRANSCRIPTIONAL REPRESSOR YVOA, SULFATE ION | Authors: | Resch, M, Schiltz, E, Titgemeyer, F, Muller, Y.A. | Deposit date: | 2009-10-12 | Release date: | 2010-01-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Insight Into the Induction Mechanism of the Gntr/Hutc Bacterial Transcription Regulator Yvoa Nucleic Acids Res., 38, 2010
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6ODM
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![BU of 6odm by Molmil](/molmil-images/mine/6odm) | Herpes simplex virus type 1 (HSV-1) portal vertex-adjacent capsid/CATC, asymmetric unit | Descriptor: | Capsid vertex component 1, Capsid vertex component 2, Large tegument protein deneddylase, ... | Authors: | Liu, Y.T, Jih, J, Dai, X.H, Bi, G.Q, Zhou, Z.H. | Deposit date: | 2019-03-26 | Release date: | 2019-06-19 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome. Nature, 570, 2019
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4K3O
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![BU of 4k3o by Molmil](/molmil-images/mine/4k3o) | E. coli sliding clamp in complex with AcQADLF | Descriptor: | (ACE)QADLF, 1,2-ETHANEDIOL, CALCIUM ION, ... | Authors: | Yin, Z, Oakley, A.J. | Deposit date: | 2013-04-11 | Release date: | 2013-05-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and Thermodynamic Dissection of Linear Motif Recognition by the E. coli Sliding Clamp J.Med.Chem., 56, 2013
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3KCC
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![BU of 3kcc by Molmil](/molmil-images/mine/3kcc) | Crystal structure of D138L mutant of Catabolite Gene Activator Protein | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator | Authors: | Tao, W.B, Gao, Z.Q, Zhou, J.H, Dong, Y.H, Yu, S.N. | Deposit date: | 2009-10-21 | Release date: | 2009-11-17 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | The 1.6A resolution structure of activated D138L mutant of catabolite gene activator protein with two cAMP bound in each monomer Int.J.Biol.Macromol., 48, 2011
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4K3P
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![BU of 4k3p by Molmil](/molmil-images/mine/4k3p) | E. coli sliding clamp in complex with AcQLALF | Descriptor: | (ACE)QLALF, 1,2-ETHANEDIOL, CALCIUM ION, ... | Authors: | Yin, Z, Oakley, A.J. | Deposit date: | 2013-04-11 | Release date: | 2013-05-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural and Thermodynamic Dissection of Linear Motif Recognition by the E. coli Sliding Clamp J.Med.Chem., 56, 2013
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