7R9W
| LC3A in complex with Fragment 1-1 | Descriptor: | 4-phenoxybenzoic acid, GLYCEROL, Microtubule-associated proteins 1A/1B light chain 3A | Authors: | Rouge, L, Steffek, M, Helgason, E, Dueber, E, Mulvihill, M. | Deposit date: | 2021-06-29 | Release date: | 2022-01-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands. Biochemistry, 62, 2023
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7R9Z
| LC3A in complex with Fragment 2-3 | Descriptor: | (5-fluoro-1H-indol-3-yl)acetic acid, Microtubule-associated proteins 1A/1B light chain 3A | Authors: | Rouge, L, Steffek, M, Helgason, E, Dueber, E, Mulvihill, M. | Deposit date: | 2021-06-29 | Release date: | 2022-01-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands. Biochemistry, 62, 2023
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7RA0
| LC3A in complex with Fragment 2-10 | Descriptor: | (5-ethyl-2-methyl-1H-indol-3-yl)acetic acid, Microtubule-associated proteins 1A/1B light chain 3A | Authors: | Rouge, L, Steffek, M, Helgason, E, Dueber, E, Mulvihill, M. | Deposit date: | 2021-06-29 | Release date: | 2022-01-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands. Biochemistry, 62, 2023
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3I2N
| Crystal Structure of WD40 repeats protein WDR92 | Descriptor: | WD repeat-containing protein 92 | Authors: | Amaya, M.F, Li, Z, He, H, Seitova, A, Ni, S, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Bountra, C, Bochkarev, A, Min, J, Ouyang, H, Structural Genomics Consortium (SGC) | Deposit date: | 2009-06-29 | Release date: | 2009-08-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure and function of WD40 domain proteins. Protein Cell, 2, 2011
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8CBJ
| Cryo-EM structure of Otu2-bound cytoplasmic pre-40S ribosome biogenesis complex | Descriptor: | 20S pre-ribosomal RNA, 20S-pre-rRNA D-site endonuclease NOB1, 40S ribosomal protein S0-A, ... | Authors: | Ikeuchi, K, Buschauer, R, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | Deposit date: | 2023-01-25 | Release date: | 2023-05-24 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2. Nat Commun, 14, 2023
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8CAS
| Cryo-EM structure of native Otu2-bound ubiquitinated 48S initiation complex (partial) | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | Authors: | Ikeuchi, K, Buschauer, R, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | Deposit date: | 2023-01-24 | Release date: | 2023-05-24 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2. Nat Commun, 14, 2023
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2DYH
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7TFE
| L. monocytogenes GS(12) - apo | Descriptor: | Glutamine synthetase, MAGNESIUM ION | Authors: | Travis, B.A, Peck, J, Schumacher, M.A. | Deposit date: | 2022-01-06 | Release date: | 2022-06-29 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria. Nat Commun, 13, 2022
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7TFD
| P. polymyxa GS(12) - apo | Descriptor: | Glutamine synthetase, MAGNESIUM ION | Authors: | Travis, B.A, Peck, J, Schumacher, M.A. | Deposit date: | 2022-01-06 | Release date: | 2022-06-29 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria. Nat Commun, 13, 2022
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4BL7
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4UDS
| Crystal structure of MbdR regulator from Azoarcus sp. CIB | Descriptor: | MBDR REGULATOR | Authors: | Liu, H, Liu, H.X, MacMahon, S.A, Juarez, J.F, Zamarro, M.T, Eberlein, C, Boll, M, Carmona, M, Diaz, E, Naismith, J.H. | Deposit date: | 2014-12-11 | Release date: | 2014-12-24 | Last modified: | 2017-09-13 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Unraveling the Specific Regulation of the Mbd Central Pathway for the Anaerobic Degradation of 3-Methylbenzoate. J.Biol.Chem., 290, 2015
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8P0D
| Human 14-3-3 sigma in complex with human MDM2 peptide | Descriptor: | 14-3-3 protein sigma, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Roversi, P, Ward, J, Doveston, R, Kwon, H, Romartinez Alonso, B. | Deposit date: | 2023-05-10 | Release date: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Characterizing the protein-protein interaction between MDM2 and 14-3-3 sigma ; proof of concept for small molecule stabilization. J.Biol.Chem., 300, 2024
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7TGH
| Cryo-EM structure of respiratory super-complex CI+III2 from Tetrahymena thermophila | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2 iron, ... | Authors: | Zhou, L, Maldonado, M, Padavannil, A, Guo, F, Letts, J.A. | Deposit date: | 2022-01-07 | Release date: | 2022-04-06 | Last modified: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structures of Tetrahymena 's respiratory chain reveal the diversity of eukaryotic core metabolism. Science, 376, 2022
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6KWY
| human PA200-20S complex | Descriptor: | INOSITOL HEXAKISPHOSPHATE, Proteasome activator complex subunit 4, Proteasome subunit alpha type-1, ... | Authors: | Ouyang, S, Hongxin, G. | Deposit date: | 2019-09-09 | Release date: | 2020-04-01 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.72 Å) | Cite: | Cryo-EM structures of the human PA200 and PA200-20S complex reveal regulation of proteasome gate opening and two PA200 apertures. Plos Biol., 18, 2020
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3U5O
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2J5B
| Structure of the Tyrosyl tRNA synthetase from Acanthamoeba polyphaga Mimivirus complexed with tyrosynol | Descriptor: | 4-[(2S)-2-amino-3-hydroxypropyl]phenol, TYROSYL-TRNA SYNTHETASE | Authors: | Abergel, C, Rudinger-thirion, J, Giege, R, Claverie, J.M. | Deposit date: | 2006-09-13 | Release date: | 2007-09-25 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Virus-Encoded Aminoacyl-tRNA Synthetases: Structural and Functional Characterization of Mimivirus Tyrrs and Metrs. J.Virol., 81, 2007
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3TJ2
| Structure of a novel submicromolar MDM2 inhibitor | Descriptor: | 3-{(1S)-2-(tert-butylamino)-1-[(4-chlorobenzyl)(formyl)amino]-2-oxoethyl}-6-chloro-1H-indole-2-carboxylic acid, E3 ubiquitin-protein ligase Mdm2, POTASSIUM ION | Authors: | Wolf, S, Huang, Y, Popowicz, G.M, Goda, S, Holak, T.A, Doemling, A. | Deposit date: | 2011-08-23 | Release date: | 2012-09-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Ugi Multicomponent Reaction Derived p53-Mdm2 Antagonists To be published
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3U5N
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3U5P
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5CLQ
| Ran Y39A in complex with GPPNHP and RanBD1 | Descriptor: | E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... | Authors: | Vetter, I.R, Brucker, S. | Deposit date: | 2015-07-16 | Release date: | 2015-09-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Catalysis of GTP Hydrolysis by Small GTPases at Atomic Detail by Integration of X-ray Crystallography, Experimental, and Theoretical IR Spectroscopy. J.Biol.Chem., 290, 2015
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4L39
| Crystal structure of GH3.12 from Arabidopsis thaliana in complex with AMPCPP and salicylate | Descriptor: | 2-HYDROXYBENZOIC ACID, 4-substituted benzoates-glutamate ligase GH3.12, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... | Authors: | Zubieta, C, Jez, J.M, Brown, E, Marcellin, R, Kapp, U, Round, A, Westfall, C. | Deposit date: | 2013-06-05 | Release date: | 2013-10-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Determination of the GH3.12 protein conformation through HPLC-integrated SAXS measurements combined with X-ray crystallography. Acta Crystallogr.,Sect.D, 69, 2013
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2LUA
| Solution structure of CXC domain of MSL2 | Descriptor: | Protein male-specific lethal-2, ZINC ION | Authors: | Feng, Y, Ye, K, Zheng, S, Wang, J. | Deposit date: | 2012-06-09 | Release date: | 2012-10-17 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution Structure of MSL2 CXC Domain Reveals an Unusual Zn(3)Cys(9) Cluster and Similarity to Pre-SET Domains of Histone Lysine Methyltransferases. Plos One, 7, 2012
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2G45
| Co-crystal structure of znf ubp domain from the deubiquitinating enzyme isopeptidase T (isot) in complex with ubiquitin | Descriptor: | CHLORIDE ION, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 5, ... | Authors: | Reyes-Turcu, F.E, Horton, J.R, Mullally, J.E, Heroux, A, Cheng, X, Wilkinson, K.D. | Deposit date: | 2006-02-21 | Release date: | 2006-04-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | The Ubiquitin Binding Domain ZnF UBP Recognizes the C-Terminal Diglycine Motif of Unanchored Ubiquitin. Cell(Cambridge,Mass.), 124, 2006
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2G43
| Structure of the ZNF UBP domain from deubiquitinating enzyme isopeptidase T (IsoT) | Descriptor: | UNKNOWN ATOM OR ION, Ubiquitin carboxyl-terminal hydrolase 5, ZINC ION | Authors: | Reyes-Turcu, F.E, Horton, J.R, Mullally, J.E, Heroux, A, Cheng, X, Wilkinson, K.D. | Deposit date: | 2006-02-21 | Release date: | 2006-04-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | The Ubiquitin Binding Domain ZnF UBP Recognizes the C-Terminal Diglycine Motif of Unanchored Ubiquitin. Cell(Cambridge,Mass.), 124, 2006
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2K28
| Solution NMR structure of the chromo domain of the chromobox protein homolog 4 | Descriptor: | E3 SUMO-protein ligase CBX4 | Authors: | Kaustov, L, Lemak, A, Quyang, H, Fares, C, Gutmanas, A, Ravichandran, M, Loppnau, P, Bountra, C, Weigelt, J, Edwards, A.M, Min, J, Arrowsmith, C.H, Structural Genomics Consortium (SGC) | Deposit date: | 2008-03-27 | Release date: | 2008-04-08 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of the chromo domain of the chromobox protein homolog 4. To be Published
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