3TJ2
Structure of a novel submicromolar MDM2 inhibitor
Summary for 3TJ2
Entry DOI | 10.2210/pdb3tj2/pdb |
Related | 1YCR |
Descriptor | E3 ubiquitin-protein ligase Mdm2, 3-{(1S)-2-(tert-butylamino)-1-[(4-chlorobenzyl)(formyl)amino]-2-oxoethyl}-6-chloro-1H-indole-2-carboxylic acid, POTASSIUM ION, ... (4 entities in total) |
Functional Keywords | cell cycle control, dna repair, oncoprotein, p53, nucleus, protein binding-inhibitor complex, protein binding/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleoplasm: Q00987 |
Total number of polymer chains | 2 |
Total formula weight | 23317.14 |
Authors | Wolf, S.,Huang, Y.,Popowicz, G.M.,Goda, S.,Holak, T.A.,Doemling, A. (deposition date: 2011-08-23, release date: 2012-09-12, Last modification date: 2023-09-13) |
Primary citation | Wolf, S.,Huang, Y.,Popowicz, G.M.,Goda, S.,Holak, T.A.,Doemling, A. Ugi Multicomponent Reaction Derived p53-Mdm2 Antagonists To be published, |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report