3TJ2

Structure of a novel submicromolar MDM2 inhibitor

Summary for 3TJ2

• Entry DOI: 10.2210/pdb3tj2/pdb
• Related: 1YCR
• Descriptor: E3 ubiquitin-protein ligase Mdm2, 3-{(1S)-2-(tert-butylamino)-1-[(4-chlorobenzyl)(formyl)amino]-2-oxoethyl}-6-chloro-1H-indole-2-carboxylic acid, POTASSIUM ION, ... (4 entities in total)
• Functional Keywords: cell cycle control, dna repair, oncoprotein, p53, nucleus, protein binding-inhibitor complex, protein binding/inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus, nucleoplasm: Q00987
• Total number of polymer chains: 2
• Total formula weight: 23317.14

Authors

Wolf, S.,Huang, Y.,Popowicz, G.M.,Goda, S.,Holak, T.A.,Doemling, A. (deposition date: 2011-08-23, release date: 2012-09-12, Last modification date: 2023-09-13)

• Primary citation: Wolf, S.,Huang, Y.,Popowicz, G.M.,Goda, S.,Holak, T.A.,Doemling, A.; Ugi Multicomponent Reaction Derived p53-Mdm2 Antagonists; To be published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)