3TJ2
Structure of a novel submicromolar MDM2 inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, C) | E3 ubiquitin-protein ligase Mdm2 | polymer | 95 | 11143.1 | 2 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (human) | Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2 |
| 2 | C, F (A, C) | 3-{(1S)-2-(tert-butylamino)-1-[(4-chlorobenzyl)(formyl)amino]-2-oxoethyl}-6-chloro-1H-indole-2-carboxylic acid | non-polymer | 476.4 | 2 | Chemie (TJ2) | |||
| 3 | D, E (A) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 4 | G, H (A, C) | water | water | 18.0 | 149 | Chemie (HOH) |
Sequence modifications
A, C: 18 - 111 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Met 17 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 22286.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1030.9 | |
| All* | Total formula weight | 23317.1 |
