3TJ2
Structure of a novel submicromolar MDM2 inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0051726 | biological_process | regulation of cell cycle |
| C | 0005634 | cellular_component | nucleus |
| C | 0043066 | biological_process | negative regulation of apoptotic process |
| C | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE TJ2 A 1 |
| Chain | Residue |
| A | LEU54 |
| A | TYR100 |
| A | HOH119 |
| A | HOH137 |
| A | GLY58 |
| A | ILE61 |
| A | MET62 |
| A | TYR67 |
| A | PHE91 |
| A | VAL93 |
| A | HIS96 |
| A | ILE99 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE K A 112 |
| Chain | Residue |
| A | THR47 |
| A | HOH134 |
| A | HOH145 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE TJ2 C 1 |
| Chain | Residue |
| C | HOH7 |
| C | HOH10 |
| C | LEU54 |
| C | GLY58 |
| C | ILE61 |
| C | MET62 |
| C | VAL93 |
| C | HIS96 |
| C | TYR100 |
| C | HOH140 |
