3TJ2
Structure of a novel submicromolar MDM2 inhibitor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005634 | cellular_component | nucleus |
A | 0043066 | biological_process | negative regulation of apoptotic process |
A | 0051726 | biological_process | regulation of cell cycle |
C | 0005634 | cellular_component | nucleus |
C | 0043066 | biological_process | negative regulation of apoptotic process |
C | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE TJ2 A 1 |
Chain | Residue |
A | LEU54 |
A | TYR100 |
A | HOH119 |
A | HOH137 |
A | GLY58 |
A | ILE61 |
A | MET62 |
A | TYR67 |
A | PHE91 |
A | VAL93 |
A | HIS96 |
A | ILE99 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE K A 112 |
Chain | Residue |
A | THR47 |
A | HOH134 |
A | HOH145 |
site_id | AC3 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE TJ2 C 1 |
Chain | Residue |
C | HOH7 |
C | HOH10 |
C | LEU54 |
C | GLY58 |
C | ILE61 |
C | MET62 |
C | VAL93 |
C | HIS96 |
C | TYR100 |
C | HOH140 |