8H34
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![BU of 8h34 by Molmil](/molmil-images/mine/8h34) | Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 hexameric complex | Descriptor: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | Authors: | Hu, Y, Mao, Q, Chen, Z, Sun, L. | Deposit date: | 2022-10-07 | Release date: | 2023-10-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (7.99 Å) | Cite: | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
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8H3Q
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![BU of 8h3q by Molmil](/molmil-images/mine/8h3q) | Cryo-EM Structure of the CAND1-Cul3-Rbx1 complex | Descriptor: | Cullin-3, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... | Authors: | Hu, Y, Mao, Q, Chen, Z, Sun, L. | Deposit date: | 2022-10-09 | Release date: | 2023-10-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.76 Å) | Cite: | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
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8H35
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![BU of 8h35 by Molmil](/molmil-images/mine/8h35) | Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 octameric complex | Descriptor: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | Authors: | Hu, Y, Mao, Q, Chen, Z, Sun, L. | Deposit date: | 2022-10-08 | Release date: | 2023-10-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (7.41 Å) | Cite: | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
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8H37
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![BU of 8h37 by Molmil](/molmil-images/mine/8h37) | Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a tetrameric complex | Descriptor: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | Authors: | Hu, Y, Mao, Q, Chen, Z, Sun, L. | Deposit date: | 2022-10-08 | Release date: | 2023-10-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (7.52 Å) | Cite: | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
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8H3R
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![BU of 8h3r by Molmil](/molmil-images/mine/8h3r) | Cryo-EM Structure of the KBTBD2-CRL3~N8 dimeric complex | Descriptor: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | Authors: | Hu, Y, Mao, Q, Chen, Z, Sun, L. | Deposit date: | 2022-10-09 | Release date: | 2023-10-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (6.36 Å) | Cite: | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
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8H38
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![BU of 8h38 by Molmil](/molmil-images/mine/8h38) | Cryo-EM Structure of the KBTBD2-CRL3~N8-CSN(mutate) complex | Descriptor: | COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ... | Authors: | Hu, Y, Mao, Q, Chen, Z, Sun, L. | Deposit date: | 2022-10-08 | Release date: | 2023-10-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.25 Å) | Cite: | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
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8AJM
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![BU of 8ajm by Molmil](/molmil-images/mine/8ajm) | Structure of human DDB1-DCAF12 in complex with the C-terminus of CCT5 | Descriptor: | DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1, T-complex protein 1 subunit epsilon | Authors: | Pla-Prats, C, Cavadini, S, Kempf, G, Thoma, N.H. | Deposit date: | 2022-07-28 | Release date: | 2022-11-09 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | Recognition of the CCT5 di-Glu degron by CRL4 DCAF12 is dependent on TRiC assembly. Embo J., 42, 2023
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8AJN
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![BU of 8ajn by Molmil](/molmil-images/mine/8ajn) | Structure of the human DDB1-DCAF12 complex | Descriptor: | DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1 | Authors: | Pla-Prats, C, Cavadini, S, Kempf, G, Thoma, N.H. | Deposit date: | 2022-07-28 | Release date: | 2022-11-09 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Recognition of the CCT5 di-Glu degron by CRL4 DCAF12 is dependent on TRiC assembly. Embo J., 42, 2023
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8AJO
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![BU of 8ajo by Molmil](/molmil-images/mine/8ajo) | Negative-stain electron microscopy structure of DDB1-DCAF12-CCT5 | Descriptor: | DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1, T-complex protein 1 subunit epsilon | Authors: | Pla-Prats, C, Cavadini, S, Kempf, G, Thoma, N.H. | Deposit date: | 2022-07-28 | Release date: | 2022-11-09 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (30.6 Å) | Cite: | Recognition of the CCT5 di-Glu degron by CRL4 DCAF12 is dependent on TRiC assembly. Embo J., 42, 2023
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8B3F
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![BU of 8b3f by Molmil](/molmil-images/mine/8b3f) | Pol II-CSB-CSA-DDB1-ELOF1 | Descriptor: | DNA damage-binding protein 1, DNA excision repair protein ERCC-6, DNA excision repair protein ERCC-8, ... | Authors: | Kokic, G, Cramer, P. | Deposit date: | 2022-09-16 | Release date: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Pol II-CSB-CSA-DDB1-ELOF1 structure. To Be Published
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8B3D
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![BU of 8b3d by Molmil](/molmil-images/mine/8b3d) | Structure of the Pol II-TCR-ELOF1 complex. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA damage-binding protein 1, ... | Authors: | Kokic, G, Cramer, P. | Deposit date: | 2022-09-16 | Release date: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structure of the Pol II-TCR-ELOF1 complex. To Be Published
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8BYL
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![BU of 8byl by Molmil](/molmil-images/mine/8byl) | Cryo-EM structure of SKP1-SKP2-CKS1 from the SCFSKP2 E3 ligase complex | Descriptor: | Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinases regulatory subunit 1, S-phase kinase-associated protein 1, ... | Authors: | Rowland, R.J, Salamina, M, Endicott, J.A, Noble, M.E.M. | Deposit date: | 2022-12-13 | Release date: | 2023-06-28 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1. Sci Rep, 13, 2023
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4CI2
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![BU of 4ci2 by Molmil](/molmil-images/mine/4ci2) | Structure of the DDB1-CRBN E3 ubiquitin ligase bound to lenalidomide | Descriptor: | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Lenalidomide, ... | Authors: | Fischer, E.S, Boehm, K, Thoma, N.H. | Deposit date: | 2013-12-05 | Release date: | 2014-07-16 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide. Nature, 512, 2014
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4CI3
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![BU of 4ci3 by Molmil](/molmil-images/mine/4ci3) | Structure of the DDB1-CRBN E3 ubiquitin ligase bound to Pomalidomide | Descriptor: | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Pomalidomide, ... | Authors: | Fischer, E.S, Boehm, K, Thoma, N.H. | Deposit date: | 2013-12-05 | Release date: | 2014-07-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide. Nature, 512, 2014
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4CI1
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![BU of 4ci1 by Molmil](/molmil-images/mine/4ci1) | Structure of the DDB1-CRBN E3 ubiquitin ligase bound to thalidomide | Descriptor: | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Thalidomide, ... | Authors: | Fischer, E.S, Boehm, K, Thoma, N.H. | Deposit date: | 2013-12-05 | Release date: | 2014-07-16 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide. Nature, 512, 2014
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8JAQ
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![BU of 8jaq by Molmil](/molmil-images/mine/8jaq) | Structure of CRL2APPBP2 bound with RxxGP degron (tetramer) | Descriptor: | Amyloid protein-binding protein 2, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | Authors: | Zhao, S, Zhang, K, Xu, C. | Deposit date: | 2023-05-06 | Release date: | 2023-10-18 | Last modified: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Molecular basis for C-degron recognition by CRL2 APPBP2 ubiquitin ligase. Proc.Natl.Acad.Sci.USA, 120, 2023
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8JAS
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![BU of 8jas by Molmil](/molmil-images/mine/8jas) | Structure of CRL2APPBP2 bound with RxxGPAA degron (tetramer) | Descriptor: | Amyloid protein-binding protein 2, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | Authors: | Zhao, S, Zhang, K, Xu, C. | Deposit date: | 2023-05-07 | Release date: | 2023-10-18 | Last modified: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Molecular basis for C-degron recognition by CRL2 APPBP2 ubiquitin ligase. Proc.Natl.Acad.Sci.USA, 120, 2023
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8JAV
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![BU of 8jav by Molmil](/molmil-images/mine/8jav) | Structure of CRL2APPBP2 bound with the C-degron of MRPL28 (tetramer) | Descriptor: | Amyloid protein-binding protein 2, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | Authors: | Zhao, S, Zhang, K, Xu, C. | Deposit date: | 2023-05-07 | Release date: | 2023-10-18 | Last modified: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Molecular basis for C-degron recognition by CRL2 APPBP2 ubiquitin ligase. Proc.Natl.Acad.Sci.USA, 120, 2023
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8JE1
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![BU of 8je1 by Molmil](/molmil-images/mine/8je1) | An asymmetry dimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complexed with BEX2 | Descriptor: | Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ... | Authors: | Dai, Z, Liang, L, Yin, Y.X. | Deposit date: | 2023-05-15 | Release date: | 2024-02-28 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.95 Å) | Cite: | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase. Embo J., 43, 2024
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8OIZ
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![BU of 8oiz by Molmil](/molmil-images/mine/8oiz) | Crystal structure of human CRBN-DDB1 in complex with Pomalidomide | Descriptor: | 1,2-ETHANEDIOL, DNA damage-binding protein 1, Protein cereblon, ... | Authors: | Le Bihan, Y.-V, Cabry, M.P, van Montfort, R.L.M. | Deposit date: | 2023-03-23 | Release date: | 2023-07-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A Degron Blocking Strategy Towards Improved CRL4 CRBN Recruiting PROTAC Selectivity. Chembiochem, 24, 2023
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8OJH
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![BU of 8ojh by Molmil](/molmil-images/mine/8ojh) | Crystal structure of human CRBN-DDB1 in complex with compound 4 | Descriptor: | 1,2-ETHANEDIOL, 4-azanyl-2-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-7-methoxy-isoindole-1,3-dione, DNA damage-binding protein 1, ... | Authors: | Cabry, M.P, Le Bihan, Y.-V, van Montfort, R.L.M. | Deposit date: | 2023-03-24 | Release date: | 2023-07-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | A Degron Blocking Strategy Towards Improved CRL4 CRBN Recruiting PROTAC Selectivity. Chembiochem, 24, 2023
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8K9I
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![BU of 8k9i by Molmil](/molmil-images/mine/8k9i) | Structure of CUL3-RBX1-KLHL22 complex without CUL3 NA motif | Descriptor: | Cullin-3, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... | Authors: | Wang, W, Ling, L, Dai, Z, Zuo, P, Yin, Y. | Deposit date: | 2023-08-01 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3 KLHL22. Nat Commun, 15, 2024
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8IJ1
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![BU of 8ij1 by Molmil](/molmil-images/mine/8ij1) | Protomer 1 and 2 of the asymmetry trimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complex | Descriptor: | Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ... | Authors: | Dai, Z, Liang, L, Yin, Y.X. | Deposit date: | 2023-02-24 | Release date: | 2024-02-28 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase. Embo J., 43, 2024
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8KHP
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![BU of 8khp by Molmil](/molmil-images/mine/8khp) | CULLIN3-KLHL22-RBX1 E3 ligase | Descriptor: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch-like protein 22 | Authors: | Su, M.-Y, Su, M.-Y. | Deposit date: | 2023-08-22 | Release date: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme. Structure, 31, 2023
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8OR3
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![BU of 8or3 by Molmil](/molmil-images/mine/8or3) | CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1 | Descriptor: | Cullin-1, Cullin-associated NEDD8-dissociated protein 1, DCN1-like protein 1, ... | Authors: | Shaaban, M, Clapperton, J.A, Ding, S, Maeots, M.E, Enchev, R.I. | Deposit date: | 2023-04-13 | Release date: | 2023-06-28 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange. Mol.Cell, 83, 2023
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