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8CEV
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BU of 8cev by Molmil
Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO1119
Descriptor: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-azanyl-5-iodanyl-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
Authors:Klima, M, Silhan, J, Boura, E.
Deposit date:2023-02-02
Release date:2023-04-05
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase.
Nat Commun, 14, 2023
8CER
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BU of 8cer by Molmil
Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO494
Descriptor: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-naphthalen-1-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
Authors:Klima, M, Silhan, J, Boura, E.
Deposit date:2023-02-02
Release date:2023-04-05
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase.
Nat Commun, 14, 2023
8CEQ
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BU of 8ceq by Molmil
Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO427
Descriptor: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-phenylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
Authors:Klima, M, Silhan, J, Boura, E.
Deposit date:2023-02-02
Release date:2023-04-05
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase.
Nat Commun, 14, 2023
8CES
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BU of 8ces by Molmil
Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO500
Descriptor: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-[2-(1~{H}-benzimidazol-2-yl)ethynyl]pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
Authors:Klima, M, Silhan, J, Boura, E.
Deposit date:2023-02-02
Release date:2023-04-05
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase.
Nat Commun, 14, 2023
8CET
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BU of 8cet by Molmil
Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO507
Descriptor: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-quinolin-3-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
Authors:Klima, M, Silhan, J, Boura, E.
Deposit date:2023-02-02
Release date:2023-04-05
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase.
Nat Commun, 14, 2023
8CGB
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BU of 8cgb by Molmil
Monkeypox virus VP39 in complex with SAH
Descriptor: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Silhan, J, Klima, M, Skvara, P, Boura, E.
Deposit date:2023-02-03
Release date:2023-04-26
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase.
Nat Commun, 14, 2023
8C4T
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BU of 8c4t by Molmil
Hantaan virus polymerase bound to its 5' viral RNA
Descriptor: MAGNESIUM ION, RNA (5'-R(P*UP*AP*GP*UP*AP*GP*UP*AP*GP*AP*CP*A)-3'), RNA-directed RNA polymerase L
Authors:Durieux trouilleton, Q, Arragain, B, Malet, H.
Deposit date:2023-01-04
Release date:2023-06-07
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication.
Nat Commun, 14, 2023
6IFL
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BU of 6ifl by Molmil
Cryo-EM structure of type III-A Csm-NTR complex
Descriptor: NTR, Type III-A CRISPR-associated RAMP protein Csm3, Type III-A CRISPR-associated RAMP protein Csm4, ...
Authors:You, L, Ma, J, Wang, J, Zhang, X, Wang, Y.
Deposit date:2018-09-20
Release date:2018-12-12
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference
Cell, 176, 2019
5F3T
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BU of 5f3t by Molmil
Dengue serotype 3 RNA-dependent RNA polymerase bound to JF-31-MG46
Descriptor: 2-(4-methoxy-3-phenyl-phenyl)ethanoic acid, RNA-DEPENDENT RNA POLYMERASE, ZINC ION
Authors:Noble, C.G.
Deposit date:2015-12-03
Release date:2016-02-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening.
J.Biol.Chem., 291, 2016
6IFY
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BU of 6ify by Molmil
Type III-A Csm complex, Cryo-EM structure of Csm-CTR1
Descriptor: CTR1, Type III-A CRISPR-associated RAMP protein Csm3, Type III-A CRISPR-associated RAMP protein Csm4, ...
Authors:You, L, Ma, J, Wang, J, Zhang, X, Wang, Y.
Deposit date:2018-09-21
Release date:2018-12-12
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference
Cell, 176, 2019
8CD1
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BU of 8cd1 by Molmil
70S-PHIKZ014
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Gerovac, M, Vogel, J.
Deposit date:2023-01-29
Release date:2024-01-24
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Phage proteins target and co-opt host ribosomes immediately upon infection.
Nat Microbiol, 9, 2024
4D5N
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BU of 4d5n by Molmil
Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus IRES reveal the IRES in the translocated state
Descriptor: CRICKET PARALYSIS VIRUS IRES RNA, EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1
Authors:Muhs, M, Hilal, T, Mielke, T, Skabkin, M.A, Sanbonmatsu, K.Y, Pestova, T.V, Spahn, C.M.T.
Deposit date:2014-11-06
Release date:2015-02-04
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (9 Å)
Cite:Cryo-Em of Ribosomal 80S Complexes with Termination Factors Reveals the Translocated Cricket Paralysis Virus Ires.
Mol.Cell, 57, 2015
1FOX
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BU of 1fox by Molmil
NMR STRUCTURE OF L11-C76, THE C-TERMINAL DOMAIN OF 50S RIBOSOMAL PROTEIN L11, 33 STRUCTURES
Descriptor: L11-C76
Authors:Markus, M.A, Hinck, A.P, Huang, S, Draper, D.E, Torchia, D.A.
Deposit date:1996-09-13
Release date:1997-03-12
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:High resolution solution structure of ribosomal protein L11-C76, a helical protein with a flexible loop that becomes structured upon binding to RNA.
Nat.Struct.Biol., 4, 1997
1FOW
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BU of 1fow by Molmil
NMR STRUCTURE OF L11-C76, THE C-TERMINAL DOMAIN OF 50S RIBOSOMAL PROTEIN L11, MINIMIZED AVERAGE STRUCTURE
Descriptor: L11-C76
Authors:Markus, M.A, Hinck, A.P, Huang, S, Draper, D.E, Torchia, D.A.
Deposit date:1996-09-13
Release date:1997-03-12
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:High resolution solution structure of ribosomal protein L11-C76, a helical protein with a flexible loop that becomes structured upon binding to RNA.
Nat.Struct.Biol., 4, 1997
8ASG
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BU of 8asg by Molmil
Structure of the SFTSV L protein bound in a resting state [RESTING]
Descriptor: MAGNESIUM ION, RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*GP*AP*UP*GP*A*)-3'), RNA (5'-R(*GP*AP*UP*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U*)-3'), ...
Authors:Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M.
Deposit date:2022-08-19
Release date:2023-01-18
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Nucleic Acids Res., 51, 2023
5A2Y
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BU of 5a2y by Molmil
Crystal structure of mtPAP in complex with UTP
Descriptor: MAGNESIUM ION, MITOCHONDRIAL PROTEIN, URIDINE 5'-TRIPHOSPHATE
Authors:Lapkouski, M, Hallberg, B.M.
Deposit date:2015-05-26
Release date:2015-09-09
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure of Mitochondrial Poly(A) RNA Polymerase Reveals the Structural Basis for Dimerization, ATP Selectivity and the Spax4 Disease Phenotype.
Nucleic Acids Res., 43, 2015
4X9D
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BU of 4x9d by Molmil
High-resolution structure of Hfq from Methanococcus jannaschii in complex with UMP
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Nikulin, A.D, Tishchenko, S.V, Nikonova, E.Y, Murina, V.N, Mihailina, A.O, Lekontseva, N.V.
Deposit date:2014-12-11
Release date:2015-12-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Characterization of RNA-binding properties of the archaeal Hfq-like protein from Methanococcus jannaschii.
J. Biomol. Struct. Dyn., 35, 2017
8RHS
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BU of 8rhs by Molmil
Structure of the ZnF domain from human Roquin-1
Descriptor: Roquin-1
Authors:Schlundt, A, Tants, J.N.
Deposit date:2023-12-16
Release date:2024-07-03
Last modified:2024-07-17
Method:SOLUTION NMR
Cite:Structure and RNA-binding of the helically extended Roquin CCCH-type zinc finger.
Nucleic Acids Res., 2024
7P5X
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BU of 7p5x by Molmil
Mycobacterial RNAP with transcriptional activator PafBC
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Mueller, A.U, Kummer, E, Schilling, C.M, Ban, N, Weber-Ban, E.
Deposit date:2021-07-15
Release date:2021-12-22
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Transcriptional control of mycobacterial DNA damage response by sigma adaptation.
Sci Adv, 7, 2021
5DIL
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BU of 5dil by Molmil
Crystal structure of the effector domain of the NS1 protein from influenza virus B
Descriptor: IODIDE ION, Non-structural protein 1
Authors:Guan, R, Hamilton, K, Ma, L, Montelione, G.T.
Deposit date:2015-09-01
Release date:2016-08-10
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:A Second RNA-Binding Site in the NS1 Protein of Influenza B Virus.
Structure, 24, 2016
4X9C
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BU of 4x9c by Molmil
1.4A crystal structure of Hfq from Methanococcus jannaschii
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Nikulin, A.D, Tishchenko, S.V, Nikonova, S.V, Murina, V.N, Mihailina, A.O, Lekontseva, N.V.
Deposit date:2014-12-11
Release date:2014-12-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Characterization of RNA-binding properties of the archaeal Hfq-like protein from Methanococcus jannaschii.
J. Biomol. Struct. Dyn., 35, 2017
4NWB
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BU of 4nwb by Molmil
Crystal structure of Mrt4
Descriptor: SULFATE ION, mRNA turnover protein 4
Authors:Holdermann, I, Sinning, I.
Deposit date:2013-12-06
Release date:2014-03-26
Last modified:2014-04-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle.
Nat Commun, 5, 2014
1PRZ
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BU of 1prz by Molmil
Crystal structure of pseudouridine synthase RluD catalytic module
Descriptor: Ribosomal large subunit pseudouridine synthase D
Authors:Sivaraman, J, Iannuzzi, P, Cygler, M, Matte, A, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI)
Deposit date:2003-06-20
Release date:2003-11-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the RluD pseudouridine Synthase catalytic module, an enzyme that modifies 23S rRNA and is essential for normal cell growth of Escherichia coli
J.Mol.Biol., 335, 2003
6IFU
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BU of 6ifu by Molmil
Cryo-EM structure of type III-A Csm-CTR2-dsDNA complex
Descriptor: CTR2, Type III-A CRISPR-associated RAMP protein Csm3, Type III-A CRISPR-associated RAMP protein Csm4, ...
Authors:You, L, Ma, J, Wang, J, Zhang, X, Wang, Y.
Deposit date:2018-09-21
Release date:2018-12-12
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference
Cell, 176, 2019
7XYB
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BU of 7xyb by Molmil
The cryo-EM structure of an AlpA-loaded complex
Descriptor: AlpA, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Wen, A, Feng, Y.
Deposit date:2022-06-01
Release date:2022-07-20
Last modified:2022-08-24
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis of AlpA-dependent transcription antitermination.
Nucleic Acids Res., 50, 2022

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