8CEV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8cev by Molmil](/molmil-images/mine/8cev) | Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO1119 | Descriptor: | (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-azanyl-5-iodanyl-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase | Authors: | Klima, M, Silhan, J, Boura, E. | Deposit date: | 2023-02-02 | Release date: | 2023-04-05 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase. Nat Commun, 14, 2023
|
|
8CER
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8cer by Molmil](/molmil-images/mine/8cer) | Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO494 | Descriptor: | (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-naphthalen-1-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase | Authors: | Klima, M, Silhan, J, Boura, E. | Deposit date: | 2023-02-02 | Release date: | 2023-04-05 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase. Nat Commun, 14, 2023
|
|
8CEQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ceq by Molmil](/molmil-images/mine/8ceq) | Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO427 | Descriptor: | (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-phenylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase | Authors: | Klima, M, Silhan, J, Boura, E. | Deposit date: | 2023-02-02 | Release date: | 2023-04-05 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase. Nat Commun, 14, 2023
|
|
8CES
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ces by Molmil](/molmil-images/mine/8ces) | Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO500 | Descriptor: | (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-[2-(1~{H}-benzimidazol-2-yl)ethynyl]pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase | Authors: | Klima, M, Silhan, J, Boura, E. | Deposit date: | 2023-02-02 | Release date: | 2023-04-05 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase. Nat Commun, 14, 2023
|
|
8CET
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8cet by Molmil](/molmil-images/mine/8cet) | Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO507 | Descriptor: | (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-quinolin-3-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase | Authors: | Klima, M, Silhan, J, Boura, E. | Deposit date: | 2023-02-02 | Release date: | 2023-04-05 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase. Nat Commun, 14, 2023
|
|
8CGB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8cgb by Molmil](/molmil-images/mine/8cgb) | Monkeypox virus VP39 in complex with SAH | Descriptor: | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Silhan, J, Klima, M, Skvara, P, Boura, E. | Deposit date: | 2023-02-03 | Release date: | 2023-04-26 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase. Nat Commun, 14, 2023
|
|
8C4T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8c4t by Molmil](/molmil-images/mine/8c4t) | |
6IFL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ifl by Molmil](/molmil-images/mine/6ifl) | Cryo-EM structure of type III-A Csm-NTR complex | Descriptor: | NTR, Type III-A CRISPR-associated RAMP protein Csm3, Type III-A CRISPR-associated RAMP protein Csm4, ... | Authors: | You, L, Ma, J, Wang, J, Zhang, X, Wang, Y. | Deposit date: | 2018-09-20 | Release date: | 2018-12-12 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference Cell, 176, 2019
|
|
5F3T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5f3t by Molmil](/molmil-images/mine/5f3t) | Dengue serotype 3 RNA-dependent RNA polymerase bound to JF-31-MG46 | Descriptor: | 2-(4-methoxy-3-phenyl-phenyl)ethanoic acid, RNA-DEPENDENT RNA POLYMERASE, ZINC ION | Authors: | Noble, C.G. | Deposit date: | 2015-12-03 | Release date: | 2016-02-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening. J.Biol.Chem., 291, 2016
|
|
6IFY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ify by Molmil](/molmil-images/mine/6ify) | Type III-A Csm complex, Cryo-EM structure of Csm-CTR1 | Descriptor: | CTR1, Type III-A CRISPR-associated RAMP protein Csm3, Type III-A CRISPR-associated RAMP protein Csm4, ... | Authors: | You, L, Ma, J, Wang, J, Zhang, X, Wang, Y. | Deposit date: | 2018-09-21 | Release date: | 2018-12-12 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference Cell, 176, 2019
|
|
8CD1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8cd1 by Molmil](/molmil-images/mine/8cd1) | 70S-PHIKZ014 | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Gerovac, M, Vogel, J. | Deposit date: | 2023-01-29 | Release date: | 2024-01-24 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Phage proteins target and co-opt host ribosomes immediately upon infection. Nat Microbiol, 9, 2024
|
|
4D5N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4d5n by Molmil](/molmil-images/mine/4d5n) | Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus IRES reveal the IRES in the translocated state | Descriptor: | CRICKET PARALYSIS VIRUS IRES RNA, EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1 | Authors: | Muhs, M, Hilal, T, Mielke, T, Skabkin, M.A, Sanbonmatsu, K.Y, Pestova, T.V, Spahn, C.M.T. | Deposit date: | 2014-11-06 | Release date: | 2015-02-04 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (9 Å) | Cite: | Cryo-Em of Ribosomal 80S Complexes with Termination Factors Reveals the Translocated Cricket Paralysis Virus Ires. Mol.Cell, 57, 2015
|
|
1FOX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1fox by Molmil](/molmil-images/mine/1fox) | NMR STRUCTURE OF L11-C76, THE C-TERMINAL DOMAIN OF 50S RIBOSOMAL PROTEIN L11, 33 STRUCTURES | Descriptor: | L11-C76 | Authors: | Markus, M.A, Hinck, A.P, Huang, S, Draper, D.E, Torchia, D.A. | Deposit date: | 1996-09-13 | Release date: | 1997-03-12 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | High resolution solution structure of ribosomal protein L11-C76, a helical protein with a flexible loop that becomes structured upon binding to RNA. Nat.Struct.Biol., 4, 1997
|
|
1FOW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1fow by Molmil](/molmil-images/mine/1fow) | NMR STRUCTURE OF L11-C76, THE C-TERMINAL DOMAIN OF 50S RIBOSOMAL PROTEIN L11, MINIMIZED AVERAGE STRUCTURE | Descriptor: | L11-C76 | Authors: | Markus, M.A, Hinck, A.P, Huang, S, Draper, D.E, Torchia, D.A. | Deposit date: | 1996-09-13 | Release date: | 1997-03-12 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | High resolution solution structure of ribosomal protein L11-C76, a helical protein with a flexible loop that becomes structured upon binding to RNA. Nat.Struct.Biol., 4, 1997
|
|
8ASG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8asg by Molmil](/molmil-images/mine/8asg) | Structure of the SFTSV L protein bound in a resting state [RESTING] | Descriptor: | MAGNESIUM ION, RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*GP*AP*UP*GP*A*)-3'), RNA (5'-R(*GP*AP*UP*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U*)-3'), ... | Authors: | Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | Deposit date: | 2022-08-19 | Release date: | 2023-01-18 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein. Nucleic Acids Res., 51, 2023
|
|
5A2Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5a2y by Molmil](/molmil-images/mine/5a2y) | Crystal structure of mtPAP in complex with UTP | Descriptor: | MAGNESIUM ION, MITOCHONDRIAL PROTEIN, URIDINE 5'-TRIPHOSPHATE | Authors: | Lapkouski, M, Hallberg, B.M. | Deposit date: | 2015-05-26 | Release date: | 2015-09-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structure of Mitochondrial Poly(A) RNA Polymerase Reveals the Structural Basis for Dimerization, ATP Selectivity and the Spax4 Disease Phenotype. Nucleic Acids Res., 43, 2015
|
|
4X9D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4x9d by Molmil](/molmil-images/mine/4x9d) | High-resolution structure of Hfq from Methanococcus jannaschii in complex with UMP | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Nikulin, A.D, Tishchenko, S.V, Nikonova, E.Y, Murina, V.N, Mihailina, A.O, Lekontseva, N.V. | Deposit date: | 2014-12-11 | Release date: | 2015-12-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Characterization of RNA-binding properties of the archaeal Hfq-like protein from Methanococcus jannaschii. J. Biomol. Struct. Dyn., 35, 2017
|
|
8RHS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8rhs by Molmil](/molmil-images/mine/8rhs) | |
7P5X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7p5x by Molmil](/molmil-images/mine/7p5x) | Mycobacterial RNAP with transcriptional activator PafBC | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Mueller, A.U, Kummer, E, Schilling, C.M, Ban, N, Weber-Ban, E. | Deposit date: | 2021-07-15 | Release date: | 2021-12-22 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Transcriptional control of mycobacterial DNA damage response by sigma adaptation. Sci Adv, 7, 2021
|
|
5DIL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5dil by Molmil](/molmil-images/mine/5dil) | Crystal structure of the effector domain of the NS1 protein from influenza virus B | Descriptor: | IODIDE ION, Non-structural protein 1 | Authors: | Guan, R, Hamilton, K, Ma, L, Montelione, G.T. | Deposit date: | 2015-09-01 | Release date: | 2016-08-10 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | A Second RNA-Binding Site in the NS1 Protein of Influenza B Virus. Structure, 24, 2016
|
|
4X9C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4x9c by Molmil](/molmil-images/mine/4x9c) | 1.4A crystal structure of Hfq from Methanococcus jannaschii | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Nikulin, A.D, Tishchenko, S.V, Nikonova, S.V, Murina, V.N, Mihailina, A.O, Lekontseva, N.V. | Deposit date: | 2014-12-11 | Release date: | 2014-12-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Characterization of RNA-binding properties of the archaeal Hfq-like protein from Methanococcus jannaschii. J. Biomol. Struct. Dyn., 35, 2017
|
|
4NWB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4nwb by Molmil](/molmil-images/mine/4nwb) | Crystal structure of Mrt4 | Descriptor: | SULFATE ION, mRNA turnover protein 4 | Authors: | Holdermann, I, Sinning, I. | Deposit date: | 2013-12-06 | Release date: | 2014-03-26 | Last modified: | 2014-04-09 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | 60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle. Nat Commun, 5, 2014
|
|
1PRZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1prz by Molmil](/molmil-images/mine/1prz) | Crystal structure of pseudouridine synthase RluD catalytic module | Descriptor: | Ribosomal large subunit pseudouridine synthase D | Authors: | Sivaraman, J, Iannuzzi, P, Cygler, M, Matte, A, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | Deposit date: | 2003-06-20 | Release date: | 2003-11-04 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the RluD pseudouridine Synthase catalytic module, an
enzyme that modifies 23S rRNA and is essential for normal cell growth of Escherichia coli J.Mol.Biol., 335, 2003
|
|
6IFU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ifu by Molmil](/molmil-images/mine/6ifu) | Cryo-EM structure of type III-A Csm-CTR2-dsDNA complex | Descriptor: | CTR2, Type III-A CRISPR-associated RAMP protein Csm3, Type III-A CRISPR-associated RAMP protein Csm4, ... | Authors: | You, L, Ma, J, Wang, J, Zhang, X, Wang, Y. | Deposit date: | 2018-09-21 | Release date: | 2018-12-12 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference Cell, 176, 2019
|
|
7XYB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7xyb by Molmil](/molmil-images/mine/7xyb) | The cryo-EM structure of an AlpA-loaded complex | Descriptor: | AlpA, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Wen, A, Feng, Y. | Deposit date: | 2022-06-01 | Release date: | 2022-07-20 | Last modified: | 2022-08-24 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural basis of AlpA-dependent transcription antitermination. Nucleic Acids Res., 50, 2022
|
|