8CEV
Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO1119
Summary for 8CEV
| Entry DOI | 10.2210/pdb8cev/pdb |
| Descriptor | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase, (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-azanyl-5-iodanyl-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid (3 entities in total) |
| Functional Keywords | viral, methyltransferase, vp39, monkeypox, mpox, capping, enzyme, inhibitor, viral protein |
| Biological source | Monkeypox virus |
| Total number of polymer chains | 2 |
| Total formula weight | 72917.62 |
| Authors | Klima, M.,Silhan, J.,Boura, E. (deposition date: 2023-02-02, release date: 2023-04-05, Last modification date: 2024-06-19) |
| Primary citation | Silhan, J.,Klima, M.,Otava, T.,Skvara, P.,Chalupska, D.,Chalupsky, K.,Kozic, J.,Nencka, R.,Boura, E. Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase. Nat Commun, 14:2259-2259, 2023 Cited by PubMed: 37080993DOI: 10.1038/s41467-023-38019-1 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.14 Å) |
Structure validation
Download full validation report
