8CGB
Monkeypox virus VP39 in complex with SAH
Summary for 8CGB
| Entry DOI | 10.2210/pdb8cgb/pdb |
| Descriptor | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE (3 entities in total) |
| Functional Keywords | methyltransferase, ligand, monkeypox virus, transferase |
| Biological source | Monkeypox virus |
| Total number of polymer chains | 2 |
| Total formula weight | 72283.39 |
| Authors | Silhan, J.,Klima, M.,Skvara, P.,Boura, E. (deposition date: 2023-02-03, release date: 2023-04-26, Last modification date: 2024-06-19) |
| Primary citation | Silhan, J.,Klima, M.,Otava, T.,Skvara, P.,Chalupska, D.,Chalupsky, K.,Kozic, J.,Nencka, R.,Boura, E. Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase. Nat Commun, 14:2259-2259, 2023 Cited by PubMed: 37080993DOI: 10.1038/s41467-023-38019-1 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.47 Å) |
Structure validation
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