1T9X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1t9x by Molmil](/molmil-images/mine/1t9x) | |
1T9W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1t9w by Molmil](/molmil-images/mine/1t9w) | Structural Basis of Multidrug Transport by the AcrB Multidrug Efflux Pump | Descriptor: | 6-[[(2-ETHOXY-1-NAPHTHALENYL)CARBONYL]AMINO]-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLATE, Acriflavine resistance protein B | Authors: | Yu, E.W, McDermott, G, Nikaido, H. | Deposit date: | 2004-05-18 | Release date: | 2005-10-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.23 Å) | Cite: | A Periplasmic Drug-Binding Site of the AcrB Multidrug Efflux Pump: a Crystallographic and Site-Directed Mutagenesis Study J.Bacteriol., 187, 2005
|
|
1T9T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1t9t by Molmil](/molmil-images/mine/1t9t) | |
1T9Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1t9y by Molmil](/molmil-images/mine/1t9y) | |
1T9V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1t9v by Molmil](/molmil-images/mine/1t9v) | |
3D71
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3d71 by Molmil](/molmil-images/mine/3d71) | Crystal structure of E253Q BMRR bound to 22 base pair promoter site | Descriptor: | BMR promoter DNA, CITRATE ANION, IMIDAZOLE, ... | Authors: | Newberry, K.J, Huffman, J.L, Brennan, R.G. | Deposit date: | 2008-05-20 | Release date: | 2008-08-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structures of BmrR-Drug Complexes Reveal a Rigid Multidrug Binding Pocket and Transcription Activation through Tyrosine Expulsion J.Biol.Chem., 283, 2008
|
|
1R8E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1r8e by Molmil](/molmil-images/mine/1r8e) | Crystal Structure of BmrR Bound to DNA at 2.4A Resolution | Descriptor: | 5'-D(*GP*AP*CP*CP*CP*TP*CP*CP*CP*CP*TP*TP*AP*GP*GP*GP*GP*AP*GP*GP*GP*TP*C)-3', GLYCEROL, IMIDAZOLE, ... | Authors: | Newberry, K.J, Brennan, R.G. | Deposit date: | 2003-10-23 | Release date: | 2004-08-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus. J.Biol.Chem., 279, 2004
|
|
6HIJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6hij by Molmil](/molmil-images/mine/6hij) | Cryo-EM structure of the human ABCG2-MZ29-Fab complex with cholesterol and PE lipids docked | Descriptor: | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, ATP-binding cassette sub-family G member 2, CHOLESTEROL, ... | Authors: | Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Taylor, N.M.I, Bause, M, Bauer, S, Bartholomaeus, R, Stahlberg, H, Bernhardt, G, Koenig, B, Buschauer, A, Altmann, K.H, Locher, K.P. | Deposit date: | 2018-08-30 | Release date: | 2018-09-19 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.56 Å) | Cite: | Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nat.Struct.Mol.Biol., 25, 2018
|
|
3QF4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3qf4 by Molmil](/molmil-images/mine/3qf4) | Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation | Descriptor: | ABC transporter, ATP-binding protein, MAGNESIUM ION, ... | Authors: | Hohl, M, Briand, C, Gruetter, M.G, Seeger, M.A. | Deposit date: | 2011-01-21 | Release date: | 2012-03-28 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation Nat.Struct.Mol.Biol., 19, 2012
|
|
6GWH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6gwh by Molmil](/molmil-images/mine/6gwh) | |
7RY3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ry3 by Molmil](/molmil-images/mine/7ry3) | Multidrug Efflux pump AdeJ with TP-6076 bound | Descriptor: | (4S,4aS,5aR,12aS)-4-(diethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-8-[(2S)-pyrrolidin-2-yl]-7-(trifluoromethyl)-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, Efflux pump membrane transporter | Authors: | Zhang, Z. | Deposit date: | 2021-08-24 | Release date: | 2022-02-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.91 Å) | Cite: | An Analysis of the Novel Fluorocycline TP-6076 Bound to Both the Ribosome and Multidrug Efflux Pump AdeJ from Acinetobacter baumannii. Mbio, 13, 2022
|
|
3MKU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mku by Molmil](/molmil-images/mine/3mku) | Structure of a Cation-bound Multidrug and Toxin Compound Extrusion (MATE) transporter | Descriptor: | Multi antimicrobial extrusion protein (Na(+)/drug antiporter) MATE-like MDR efflux pump, RUBIDIUM ION | Authors: | He, X, Szewczyk, P, Karyakin, A, Evin, M, Hong, W.-X, Zhang, Q, Chang, G. | Deposit date: | 2010-04-15 | Release date: | 2010-09-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | Structure of a cation-bound multidrug and toxic compound extrusion transporter. Nature, 467, 2010
|
|
3MKT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mkt by Molmil](/molmil-images/mine/3mkt) | Structure of a Cation-bound Multidrug and Toxin Compound Extrusion (MATE) transporter | Descriptor: | Multi antimicrobial extrusion protein (Na(+)/drug antiporter) MATE-like MDR efflux pump | Authors: | He, X, Szewczyk, P, Karyakin, A, Evin, M, Hong, W.-X, Zhang, Q, Chang, G. | Deposit date: | 2010-04-15 | Release date: | 2010-09-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.65 Å) | Cite: | Structure of a cation-bound multidrug and toxic compound extrusion transporter. Nature, 467, 2010
|
|
2ONJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2onj by Molmil](/molmil-images/mine/2onj) | |
5MKK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5mkk by Molmil](/molmil-images/mine/5mkk) | Crystal structure of the heterodimeric ABC transporter TmrAB, a homolog of the antigen translocation complex TAP | Descriptor: | Multidrug resistance ABC transporter ATP-binding and permease protein, SULFATE ION | Authors: | Noell, A, Thomas, C, Tomasiak, T.M, Olieric, V, Wang, M, Diederichs, K, Stroud, R.M, Pos, K.M, Tampe, R. | Deposit date: | 2016-12-05 | Release date: | 2017-01-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
8CHB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8chb by Molmil](/molmil-images/mine/8chb) | Inward-facing conformation of the ABC transporter BmrA C436S/A582C cross-linked mutant | Descriptor: | Multidrug resistance ABC transporter ATP-binding/permease protein BmrA | Authors: | Di Cesare, M, Kaplan, E, Hanssen, E, Valimehr, S, Orelle, C, Jault, J.M. | Deposit date: | 2023-02-07 | Release date: | 2023-12-20 | Last modified: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | The transport activity of the multidrug ABC transporter BmrA does not require a wide separation of the nucleotide-binding domains. J.Biol.Chem., 300, 2023
|
|
8QOE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8qoe by Molmil](/molmil-images/mine/8qoe) | Inward-facing conformation of the ABC transporter BmrA | Descriptor: | Multidrug resistance ABC transporter ATP-binding/permease protein BmrA | Authors: | Di Cesare, M, Kaplan, E, Valimehr, S, Hanssen, E, Orelle, C, Jault, J.M. | Deposit date: | 2023-09-28 | Release date: | 2023-12-20 | Last modified: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | The transport activity of the multidrug ABC transporter BmrA does not require a wide separation of the nucleotide-binding domains. J.Biol.Chem., 300, 2023
|
|
2V4D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2v4d by Molmil](/molmil-images/mine/2v4d) | Re-refinement of MexA adaptor protein | Descriptor: | MULTIDRUG RESISTANCE PROTEIN MEXA, SULFATE ION | Authors: | Symmons, M.F, Bokma, E, Koronakis, E, Hughes, C, Koronakis, V. | Deposit date: | 2008-09-18 | Release date: | 2009-04-14 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The Assembled Structure of a Complete Tripartite Bacterial Multidrug Efflux Pump. Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
7OW8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ow8 by Molmil](/molmil-images/mine/7ow8) | CryoEM structure of the ABC transporter BmrA E504A mutant in complex with ATP-Mg | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug resistance ABC transporter ATP-binding/permease protein BmrA | Authors: | Gobet, A, Schoehn, G, Falson, P, Chaptal, V. | Deposit date: | 2021-06-17 | Release date: | 2022-01-19 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter. Sci Adv, 8, 2022
|
|
5YIL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5yil by Molmil](/molmil-images/mine/5yil) | Hoisting-loop in bacterial multidrug exporter AcrB is a highly flexible hinge that enables the large motion of the subdomains | Descriptor: | Multidrug efflux pump subunit AcrB | Authors: | Zwama, M, Sakurai, K, Hayashi, K, Nakashima, R, Kitagawa, K, Nishino, K, Yamaguchi, A. | Deposit date: | 2017-10-05 | Release date: | 2017-11-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Hoisting-Loop in Bacterial Multidrug Exporter AcrB Is a Highly Flexible Hinge That Enables the Large Motion of the Subdomains. Front Microbiol, 8, 2017
|
|
6GV1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6gv1 by Molmil](/molmil-images/mine/6gv1) | Crystal structure of E.coli Multidrug/H+ antiporter MdfA in outward open conformation with bound Fab fragment | Descriptor: | Fab fragment YN1074 heavy chain, Fab fragment YN1074 light chain, Major Facilitator Superfamily multidrug/H+ antiporter MdfA from E.coli, ... | Authors: | Nagarathinam, K, Parthier, C, Stubbs, M.T, Tanabe, M. | Deposit date: | 2018-06-20 | Release date: | 2018-10-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Outward open conformation of a Major Facilitator Superfamily multidrug/H+antiporter provides insights into switching mechanism. Nat Commun, 9, 2018
|
|
8JWG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jwg by Molmil](/molmil-images/mine/8jwg) | |
8JWI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jwi by Molmil](/molmil-images/mine/8jwi) | |
8JWF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jwf by Molmil](/molmil-images/mine/8jwf) | |
7JK8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7jk8 by Molmil](/molmil-images/mine/7jk8) | EmrE S64V mutant bound to tetra(4-fluorophenyl)phosphonium at pH 5.8 | Descriptor: | Multidrug SMR transporter, tetrakis(4-fluorophenyl)phosphanium | Authors: | Shcherbakov, A.A, Hisao, G, Mandala, V.S, Thomas, N.E, Soltani, M, Salter, E.A, Davis Jr, J.H, Henzler-Wildman, K.A, Hong, M. | Deposit date: | 2020-07-27 | Release date: | 2020-12-09 | Last modified: | 2024-05-01 | Method: | SOLID-STATE NMR | Cite: | Structure and dynamics of the drug-bound bacterial transporter EmrE in lipid bilayers. Nat Commun, 12, 2021
|
|