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1BXR	STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE COMPLEXED WITH THE ATP ANALOG AMPPNP Descriptor: CARBAMOYL-PHOSPHATE SYNTHASE, CHLORIDE ION, L-ornithine, ... Authors: Thoden, J.B, Wesenberg, G, Raushel, F.M, Holden, H.M. Deposit date: 1998-10-08 Release date: 1999-04-20 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Carbamoyl phosphate synthetase: closure of the B-domain as a result of nucleotide binding. Biochemistry, 38, 1999
3JZF	Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazoles series Descriptor: 2-[(2-chlorobenzyl)amino]-1-(cyclohexylmethyl)-1H-benzimidazole-5-carboxamide, Biotin carboxylase, CARBONATE ION Authors: Orth, P. Deposit date: 2009-09-23 Release date: 2009-11-03 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.13 Å) Cite: Discovery and optimization of antibacterial AccC inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
8HZ5	The homodimer of a biotin carboxylase isoform from chloroflexus aurantiacus Descriptor: Biotin carboxylase Authors: Shen, J, Wu, W, Xu, X. Deposit date: 2023-01-08 Release date: 2024-01-10 Last modified: 2024-07-24 Method: X-RAY DIFFRACTION (3 Å) Cite: Chloroflexus aurantiacus acetyl-CoA carboxylase evolves fused biotin carboxylase and biotin carboxyl carrier protein to complete carboxylation activity. Mbio, 15, 2024
8HZ4	The tetrameric structure of biotin carboxylase from Chloroflexus aurantiacus in complex with bicarbonate Descriptor: Biotin carboxylase Authors: Shen, J, Wu, W, Xu, X. Deposit date: 2023-01-08 Release date: 2024-01-10 Last modified: 2024-07-24 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Chloroflexus aurantiacus acetyl-CoA carboxylase evolves fused biotin carboxylase and biotin carboxyl carrier protein to complete carboxylation activity. Mbio, 15, 2024
8J4Z	Human 3-methylcrotonyl-CoA carboxylase in BCCP-CTS state with substrate Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... Authors: Liu, D.S, Su, J.Y. Deposit date: 2023-04-21 Release date: 2024-04-24 Method: ELECTRON MICROSCOPY (2.73 Å) Cite: Human 3-methylcrotonyl-CoA carboxylase in BCCP-CTS state with substrate To Be Published
8J7O	Human pyruvate carboxylase in BCCP-CTS state without BC Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Pyruvate carboxylase, mitochondrial Authors: Liu, D.S, Su, J.Y. Deposit date: 2023-04-27 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (3.83 Å) Cite: Human pyruvate carboxylase To Be Published
8J78	Human 3-methylcrotonyl-CoA carboxylase in BCCP-H2 state Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... Authors: Liu, D.S, Su, J.Y. Deposit date: 2023-04-27 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (3.88 Å) Cite: Human 3-methylcrotonyl-CoA carboxylase in BCCP-H2 state To Be Published
8J99	Human 3-methylcrotonyl-CoA carboxylase in BCS-mcoa state Descriptor: Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, Methylcrotonoyl-CoA carboxylase subunit alpha, ... Authors: Liu, D.S, Su, J.Y. Deposit date: 2023-05-02 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (2.87 Å) Cite: Human 3-methylcrotonyl-CoA carboxylase in BCS-mcoa state To Be Published
8J7D	Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... Authors: Liu, D.S, Su, J.Y. Deposit date: 2023-04-27 Release date: 2024-05-08 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state To Be Published
8JAK	Human MCC in MCCU state Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... Authors: Liu, D.S, Su, J.Y, Tian, X.Y. Deposit date: 2023-05-06 Release date: 2024-05-15 Method: ELECTRON MICROSCOPY (2.52 Å) Cite: Human MCC in BCCP-BCS state To Be Published
8JAW	Human MCC in MCCD state Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... Authors: Liu, D.S, Su, J.Y, Tian, X.Y. Deposit date: 2023-05-07 Release date: 2024-05-15 Method: ELECTRON MICROSCOPY (2.51 Å) Cite: Human MCC in BCCP-CTS state To Be Published
8JXM	Human 3-methylcrotonyl-CoA carboxylase in BCCP-H2 state with MCoA Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... Authors: Liu, D.S, Su, J.Y, Tian, X.Y. Deposit date: 2023-06-30 Release date: 2024-07-03 Method: ELECTRON MICROSCOPY (3.49 Å) Cite: Human 3-methylcrotonyl-CoA carboxylase in To Be Published
8JXL	Human 3-methylcrotonyl-CoA carboxylase in MCCU state with MCoA Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... Authors: Liu, D.S, Su, J.Y, Tian, X.Y. Deposit date: 2023-06-30 Release date: 2024-07-03 Method: ELECTRON MICROSCOPY (2.98 Å) Cite: Human 3-methylcrotonyl-CoA carboxylase in BCCP-BCS state with substrate To Be Published
8JXN	Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state with MCoA Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... Authors: Liu, D.S, Su, J.Y, Tian, X.Y. Deposit date: 2023-06-30 Release date: 2024-07-03 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state with substrate To Be Published
8HWL	Human Pyruvate Carboxylase Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Pyruvate carboxylase, mitochondrial Authors: Liu, D.S, Su, J.Y. Deposit date: 2022-12-30 Release date: 2024-01-31 Method: ELECTRON MICROSCOPY (5.63 Å) Cite: Human Pyruvate Carboxylase To Be Published
8K2V	3-Methylcrotonyl-CoA Carboxylase in MCCD state with Acetyl CoA Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, Methylcrotonoyl-CoA carboxylase beta chain, ... Authors: Liu, D.S, Su, J.Y, Tian, X.Y. Deposit date: 2023-07-13 Release date: 2024-07-10 Method: ELECTRON MICROSCOPY (3.52 Å) Cite: 3-Methylcrotonyl-CoA Carboxylase in BCCP-CTS-CoA state To Be Published
2QF7	Crystal structure of a complete multifunctional pyruvate carboxylase from Rhizobium etli Descriptor: CHLORIDE ION, COENZYME A, FORMIC ACID, ... Authors: St Maurice, M, Surinya, K.H, Rayment, I. Deposit date: 2007-06-27 Release date: 2007-09-04 Last modified: 2012-02-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Domain architecture of pyruvate carboxylase, a biotin-dependent multifunctional enzyme Science, 317, 2007
2V59	CRYSTAL STRUCTURE OF BIOTIN CARBOXYLASE FROM E.COLI IN COMPLEX WITH POTENT INHIBITOR 2 Descriptor: 6-(2,6-DIMETHOXYPHENYL)PYRIDO[2,3-D]PYRIMIDINE-2,7-DIAMINE, BIOTIN CARBOXYLASE Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-10-02 Release date: 2009-01-13 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: A Class of Selective Antibacterials Derived from a Protein Kinase Inhibitor Pharmacophore. Proc.Natl.Acad.Sci.USA, 106, 2009
2V58	CRYSTAL STRUCTURE OF BIOTIN CARBOXYLASE FROM E.COLI IN COMPLEX WITH POTENT INHIBITOR 1 Descriptor: 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine, BIOTIN CARBOXYLASE, CHLORIDE ION Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-10-02 Release date: 2009-01-13 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A Class of Selective Antibacterials Derived from a Protein Kinase Inhibitor Pharmacophore. Proc.Natl.Acad.Sci.USA, 106, 2009
2V5A	CRYSTAL STRUCTURE OF BIOTIN CARBOXYLASE FROM E.COLI IN COMPLEX WITH POTENT INHIBITOR 3 Descriptor: 7-(2,5-dihydropyrrol-1-yl)-6-phenyl-pyrido[6,5-d]pyrimidin-2-amine, BIOTIN CARBOXYLASE, CHLORIDE ION Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-10-02 Release date: 2009-01-13 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.31 Å) Cite: A Class of Selective Antibacterials Derived from a Protein Kinase Inhibitor Pharmacophore. Proc.Natl.Acad.Sci.USA, 106, 2009
2W6Z	Crystal structure of Biotin carboxylase from E. coli in complex with the 3-(3-Methyl-but-2-enyl)-3H-purin-6-ylamine fragment Descriptor: 3-(3-methylbut-2-en-1-yl)-3H-purin-6-amine, BIOTIN CARBOXYLASE, CHLORIDE ION Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-12-19 Release date: 2009-05-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
2VQD	Crystal Structure of Biotin Carboxylase from Pseudomonas aeruginosa complexed with AMPCP Descriptor: BIOTIN CARBOXYLASE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... Authors: Mochalkin, I. Deposit date: 2008-03-13 Release date: 2008-09-09 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Structural Evidence for Substrate-Induced Synergism and Half-Sites Reactivity in Biotin Carboxylase. Protein Sci., 17, 2008
2W6O	Crystal structure of Biotin carboxylase from E. coli in complex with 4-Amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment Descriptor: 4-amino-7,7-dimethyl-7,8-dihydroquinazolin-5(6H)-one, BIOTIN CARBOXYLASE, CHLORIDE ION Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-12-18 Release date: 2009-05-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
2W6P	Crystal structure of Biotin carboxylase from E. coli in complex with 5-Methyl-6-phenyl-quinazoline-2,4-diamine Descriptor: 5-methyl-6-phenylquinazoline-2,4-diamine, ACETYL-COA CARBOXYLASE Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-12-18 Release date: 2009-05-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
2W6M	Crystal structure of Biotin carboxylase from E. coli in complex with amino-oxazole fragment series Descriptor: (2-AMINO-1,3-OXAZOL-5-YL)-(3-BROMOPHENYL)METHANONE, BIOTIN CARBOXYLASE, CHLORIDE ION Authors: Mochalkin, I, Miller, J.R. Deposit date: 2008-12-18 Release date: 2009-05-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009

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