2H8R
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![BU of 2h8r by Molmil](/molmil-images/mine/2h8r) | Hepatocyte Nuclear Factor 1b bound to DNA: MODY5 Gene Product | Descriptor: | 5'-D(*CP*TP*TP*GP*GP*TP*TP*AP*AP*TP*AP*AP*TP*TP*CP*AP*CP*CP*AP*G)-3', 5'-D(*GP*CP*TP*GP*GP*TP*GP*AP*AP*TP*TP*AP*TP*TP*AP*AP*CP*CP*AP*A)-3', Hepatocyte nuclear factor 1-beta | Authors: | Lu, P, Rha, G.B, Chi, Y.I. | Deposit date: | 2006-06-07 | Release date: | 2007-06-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis of disease-causing mutations in hepatocyte nuclear factor 1beta. Biochemistry, 46, 2007
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4N9D
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![BU of 4n9d by Molmil](/molmil-images/mine/4n9d) | Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | Descriptor: | 1,2-ETHANEDIOL, 4-({[(4-tert-butylphenyl)sulfonyl]amino}methyl)-N-(pyridin-3-yl)benzamide, Nicotinamide phosphoribosyltransferase, ... | Authors: | Dragovich, P.S, Zhao, G, Baumeister, T, Bravo, B, Giannetti, A.M, Ho, Y, Hua, R, Li, G, Liang, X, O'Brien, T, Skelton, N.J, Wang, C, Zhao, Q, Oh, A, Wang, W, Wang, Y, Xiao, Y, Yuen, P, Zak, M, Zheng, X. | Deposit date: | 2013-10-20 | Release date: | 2014-02-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.701 Å) | Cite: | Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 24, 2014
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4MQW
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![BU of 4mqw by Molmil](/molmil-images/mine/4mqw) | Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31) | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Follicle-stimulating hormone receptor, ... | Authors: | Jiang, X, Liu, H, Chen, X, He, X. | Deposit date: | 2013-09-16 | Release date: | 2014-04-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer. J.Biol.Chem., 289, 2014
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2H1E
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2JGZ
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![BU of 2jgz by Molmil](/molmil-images/mine/2jgz) | Crystal structure of phospho-CDK2 in complex with Cyclin B | Descriptor: | CELL DIVISION PROTEIN KINASE 2, G2/MITOTIC-SPECIFIC CYCLIN-B1 | Authors: | Brown, N.R, Petri, E, Lowe, E.D, Skamnaki, V, Johnson, L.N. | Deposit date: | 2007-02-17 | Release date: | 2007-05-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Cyclin B and cyclin A confer different substrate recognition properties on CDK2. Cell Cycle, 6, 2007
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2K3Y
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4N9C
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![BU of 4n9c by Molmil](/molmil-images/mine/4n9c) | Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | Descriptor: | 5-nitro-1H-benzimidazole, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION | Authors: | Dragovich, P.S, Zhao, G, Baumeister, T, Bravo, B, Giannetti, A.M, Ho, Y, Hua, R, Li, G, Liang, X, O'Brien, T, Skelton, N.J, Wang, C, Zhao, Q, Oh, A, Wang, W, Wang, Y, Xiao, Y, Yuen, P, Zak, M, Zheng, X. | Deposit date: | 2013-10-20 | Release date: | 2014-02-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.751 Å) | Cite: | Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 24, 2014
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2HOA
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![BU of 2hoa by Molmil](/molmil-images/mine/2hoa) | STRUCTURE DETERMINATION OF THE ANTP(C39->S) HOMEODOMAIN FROM NUCLEAR MAGNETIC RESONANCE DATA IN SOLUTION USING A NOVEL STRATEGY FOR THE STRUCTURE CALCULATION WITH THE PROGRAMS DIANA, CALIBA, HABAS AND GLOMSA | Descriptor: | ANTENNAPEDIA PROTEIN | Authors: | Guntert, P, Qian, Y.-Q, Otting, G, Muller, M, Gehring, W.J, Wuthrich, K. | Deposit date: | 1992-04-04 | Release date: | 1993-10-31 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure determination of the Antp (C39----S) homeodomain from nuclear magnetic resonance data in solution using a novel strategy for the structure calculation with the programs DIANA, CALIBA, HABAS and GLOMSA. J.Mol.Biol., 217, 1991
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2HWA
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![BU of 2hwa by Molmil](/molmil-images/mine/2hwa) | Crystal structure of Lys12Thr/Cys117Val mutant of human acidic fibroblast growth factor at 1.65 angstrom resolution. | Descriptor: | FORMIC ACID, Heparin-binding growth factor 1, SULFATE ION | Authors: | Dubey, V.K, Lee, J, Somasundaram, T, Blaber, M. | Deposit date: | 2006-08-01 | Release date: | 2007-06-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Spackling the crack: stabilizing human fibroblast growth factor-1 by targeting the N and C terminus beta-strand interactions. J.Mol.Biol., 371, 2007
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2HW9
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![BU of 2hw9 by Molmil](/molmil-images/mine/2hw9) | Crystal structure of Lys12Cys/Cys117Val mutant of human acidic fibroblast Growth factor at 1.60 angstrom resolution. | Descriptor: | FORMIC ACID, Heparin-binding growth factor 1, SULFATE ION | Authors: | Dubey, V.K, Lee, J, Somasundaram, T, Blaber, M. | Deposit date: | 2006-08-01 | Release date: | 2007-06-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Spackling the crack: stabilizing human fibroblast growth factor-1 by targeting the N and C terminus beta-strand interactions. J.Mol.Biol., 371, 2007
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2JCW
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![BU of 2jcw by Molmil](/molmil-images/mine/2jcw) | REDUCED BRIDGE-BROKEN YEAST CU/ZN SUPEROXIDE DISMUTASE ROOM TEMPERATURE (298K) STRUCTURE | Descriptor: | COPPER (I) ION, CU/ZN SUPEROXIDE DISMUTASE, ZINC ION | Authors: | Hart, P.J, Balbirnie, M.M, Ogihara, N.L, Nersissian, A.M, Weiss, M.S, Valentine, J.S, Eisenberg, D. | Deposit date: | 1998-12-21 | Release date: | 1999-06-08 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A structure-based mechanism for copper-zinc superoxide dismutase. Biochemistry, 38, 1999
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2JWT
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![BU of 2jwt by Molmil](/molmil-images/mine/2jwt) | Solution structure of Engrailed homeodomain WT | Descriptor: | Segmentation polarity homeobox protein engrailed | Authors: | Religa, T.L. | Deposit date: | 2007-10-24 | Release date: | 2008-04-01 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Comparison of multiple crystal structures with NMR data for engrailed homeodomain J.Biomol.Nmr, 40, 2008
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2K40
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2LQW
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6IPU
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7ACK
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![BU of 7ack by Molmil](/molmil-images/mine/7ack) | CDK2/cyclin A2 in complex with an imidazo[1,2-c]pyrimidin-5-one inhibitor | Descriptor: | 1,2-ETHANEDIOL, 8-cyclohexyl-6~{H}-imidazo[1,2-c]pyrimidin-5-one, Cyclin-A2, ... | Authors: | Skerlova, J, Pachl, P, Rezacova, P. | Deposit date: | 2020-09-11 | Release date: | 2021-03-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Imidazo[1,2-c]pyrimidin-5(6H)-one inhibitors of CDK2: Synthesis, kinase inhibition and co-crystal structure. Eur.J.Med.Chem., 216, 2021
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6ZVC
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6ZVB
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6ZVD
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6ZVE
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7AEW
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7B5S
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![BU of 7b5s by Molmil](/molmil-images/mine/7b5s) | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-ARIH1 Ariadne. Transition State 1 | Descriptor: | Cullin-1, E3 ubiquitin-protein ligase ARIH1, E3 ubiquitin-protein ligase RBX1, ... | Authors: | Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. | Deposit date: | 2020-12-07 | Release date: | 2021-02-10 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590, 2021
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7B15
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7B13
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6JXD
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![BU of 6jxd by Molmil](/molmil-images/mine/6jxd) | |