4S05
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![BU of 4s05 by Molmil](/molmil-images/mine/4s05) | Crystal structure of Klebsiella pneumoniae PmrA in complex with PmrA box DNA | Descriptor: | BERYLLIUM TRIFLUORIDE ION, DNA (26-MER), DNA-binding transcriptional regulator BasR, ... | Authors: | Hsiao, C.D, Weng, T.H, Li, Y.C. | Deposit date: | 2014-12-30 | Release date: | 2015-11-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structure and dynamics of polymyxin-resistance-associated response regulator PmrA in complex with promoter DNA. Nat Commun, 6, 2015
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2DAO
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![BU of 2dao by Molmil](/molmil-images/mine/2dao) | Solution structure of ETS domain Transcriptional factor ETV6 protein | Descriptor: | Transcription factor ETV6 | Authors: | Niraula, T.N, Sasagawa, A, Tomizawa, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-12-14 | Release date: | 2006-12-12 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of ETS domain Transcriptional factor ETV6 protein To be Published
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3DKL
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![BU of 3dkl by Molmil](/molmil-images/mine/3dkl) | Crystal structure of phosphorylated mimic form of human NAMPT complexed with benzamide and phosphoribosyl pyrophosphate | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, BENZAMIDE, BERYLLIUM TRIFLUORIDE ION, ... | Authors: | Ho, M, Burgos, E.S, Almo, S.C, Schramm, V.L. | Deposit date: | 2008-06-25 | Release date: | 2009-08-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proc.Natl.Acad.Sci.USA, 106, 2009
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3DHD
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![BU of 3dhd by Molmil](/molmil-images/mine/3dhd) | Crystal structure of human NAMPT complexed with nicotinamide mononucleotide and pyrophosphate | Descriptor: | BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, MAGNESIUM ION, Nicotinamide phosphoribosyltransferase, ... | Authors: | Ho, M, Burgos, E.S, Almo, S.C, Schramm, V.L. | Deposit date: | 2008-06-17 | Release date: | 2009-08-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proc.Natl.Acad.Sci.USA, 106, 2009
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2DMU
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![BU of 2dmu by Molmil](/molmil-images/mine/2dmu) | Solution structure of the homeobox domain of Homeobox protein goosecoid | Descriptor: | Homeobox protein goosecoid | Authors: | Ohnishi, S, Sato, M, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-04-24 | Release date: | 2006-10-24 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the homeobox domain of Homeobox protein goosecoid To be Published
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2DOE
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![BU of 2doe by Molmil](/molmil-images/mine/2doe) | Solution structure of the third FF domain of human transcription factor CA150 | Descriptor: | Transcription elongation regulator 1 | Authors: | Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-04-28 | Release date: | 2006-10-28 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the third FF domain of human transcription factor CA150 To be Published
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4QA5
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![BU of 4qa5 by Molmil](/molmil-images/mine/4qa5) | Crystal structure of A188T/Y306F HDAC8 in complex with a tetrapeptide substrate | Descriptor: | 7-AMINO-4-METHYL-CHROMEN-2-ONE, GLYCEROL, Histone deacetylase 8, ... | Authors: | Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. | Deposit date: | 2014-05-02 | Release date: | 2014-08-06 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
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4QAL
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![BU of 4qal by Molmil](/molmil-images/mine/4qal) | |
2CRA
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![BU of 2cra by Molmil](/molmil-images/mine/2cra) | Solution structure of the homeobox domain of human homeo box B13 | Descriptor: | Homeobox protein Hox-B13 | Authors: | Seimiya, K, Hayashi, F, Nagashima, T, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-05-20 | Release date: | 2005-11-20 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the homeobox domain of human homeo box B13 To be published
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4TTH
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![BU of 4tth by Molmil](/molmil-images/mine/4tth) | Crystal structure of a CDK6/Vcyclin complex with inhibitor bound | Descriptor: | 9-cyclopentyl-N-(5-piperazin-1-ylpyridin-2-yl)pyrido[4,5]pyrrolo[1,2-d]pyrimidin-2-amine, Cyclin homolog, Cyclin-dependent kinase 6 | Authors: | Piper, D.E, Walker, N, Wang, Z. | Deposit date: | 2014-06-20 | Release date: | 2014-08-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3. J.Med.Chem., 57, 2014
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2CXK
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![BU of 2cxk by Molmil](/molmil-images/mine/2cxk) | |
4QA0
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![BU of 4qa0 by Molmil](/molmil-images/mine/4qa0) | Crystal structure of C153F HDAC8 in complex with SAHA | Descriptor: | GLYCEROL, Histone deacetylase 8, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, ... | Authors: | Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. | Deposit date: | 2014-05-02 | Release date: | 2014-08-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.242 Å) | Cite: | Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
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4QO3
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![BU of 4qo3 by Molmil](/molmil-images/mine/4qo3) | |
4QA3
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![BU of 4qa3 by Molmil](/molmil-images/mine/4qa3) | Crystal structure of T311M HDAC8 in complex with Trichostatin A (TSA) | Descriptor: | GLYCEROL, Histone deacetylase 8, POTASSIUM ION, ... | Authors: | Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. | Deposit date: | 2014-05-02 | Release date: | 2014-08-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.876 Å) | Cite: | Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
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2AFG
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![BU of 2afg by Molmil](/molmil-images/mine/2afg) | |
4S3O
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![BU of 4s3o by Molmil](/molmil-images/mine/4s3o) | PCGF5-RING1B-UbcH5c complex | Descriptor: | E3 ubiquitin-protein ligase RING2, Polycomb group RING finger protein 5, Ubiquitin-conjugating enzyme E2 D3, ... | Authors: | Taherbhoy, A.M, Cochran, A.G. | Deposit date: | 2015-03-23 | Release date: | 2015-07-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase. Nat Commun, 6, 2015
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2DMT
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![BU of 2dmt by Molmil](/molmil-images/mine/2dmt) | Solution structure of the homeobox domain of Homeobox protein BarH-like 1 | Descriptor: | Homeobox protein BarH-like 1 | Authors: | Ohnishi, S, Yoneyama, M, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-04-24 | Release date: | 2006-10-24 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the homeobox domain of Homeobox protein BarH-like 1 To be Published
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2DOF
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![BU of 2dof by Molmil](/molmil-images/mine/2dof) | Solution structure of the fourth FF domain of human transcription factor CA150 | Descriptor: | Transcription elongation regulator 1 | Authors: | Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-04-28 | Release date: | 2006-10-28 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the fourth FF domain of human transcription factor CA150 To be Published
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2DJN
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![BU of 2djn by Molmil](/molmil-images/mine/2djn) | The solution structure of the homeobox domain of human Homeobox protein DLX-5 | Descriptor: | Homeobox protein DLX-5 | Authors: | Sasagawa, A, Ohnishi, S, Tochio, N, Saito, K, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-04-05 | Release date: | 2006-10-05 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | The solution structure of the homeobox domain of human Homeobox protein DLX-5 To be Published
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2DO3
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![BU of 2do3 by Molmil](/molmil-images/mine/2do3) | Solution structure of the third KOW motif of transcription elongation factor SPT5 | Descriptor: | Transcription elongation factor SPT5 | Authors: | Tanabe, W, Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-04-27 | Release date: | 2006-10-27 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the third KOW motif of transcription elongation factor SPT5 To be Published
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3F0R
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![BU of 3f0r by Molmil](/molmil-images/mine/3f0r) | Crystal Structure Analysis of Human HDAC8 complexed with trichostatin A in a new monoclinic crystal form | Descriptor: | Histone deacetylase 8, POTASSIUM ION, TRICHOSTATIN A, ... | Authors: | Dowling, D.P, Gantt, S.L, Gattis, S.G, Fierke, C.A, Christianson, D.W. | Deposit date: | 2008-10-25 | Release date: | 2008-12-30 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry, 47, 2008
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4J1Z
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![BU of 4j1z by Molmil](/molmil-images/mine/4j1z) | |
2B53
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![BU of 2b53 by Molmil](/molmil-images/mine/2b53) | |
2B55
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![BU of 2b55 by Molmil](/molmil-images/mine/2b55) | Human cyclin dependent kinase 2 (cdk2) complexed with indenopyraxole DIN-101312 | Descriptor: | 2-(4-(AMINOMETHYL)PIPERIDIN-1-YL)-N-(3_CYCLOHEXYL-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)ACETAMIDE, Cell division protein kinase 2 | Authors: | Muckelbauer, J. | Deposit date: | 2005-09-27 | Release date: | 2005-10-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 3. Structure Activity Relationships at C3 J.Med.Chem., 45, 2002
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2B54
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![BU of 2b54 by Molmil](/molmil-images/mine/2b54) | Human cyclin dependent kinase 2 (CKD2)complexed with DIN-232305 | Descriptor: | 6-(3,4-DIHYDROXYBENZYL)-3-ETHYL-1-(2,4,6-TRICHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4(5H)-ONE, Cell division protein kinase 2 | Authors: | Chang, C.-C. | Deposit date: | 2005-09-27 | Release date: | 2005-10-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1h-pyraxolo[3,4-d]pyrimidin-4-one inhibitors of cyclin dependent kinases J.Med.Chem., 47, 2004
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