3DHD

Crystal structure of human NAMPT complexed with nicotinamide mononucleotide and pyrophosphate

Summary for 3DHD

Entry DOI	10.2210/pdb3dhd/pdb
Related	3DGR 3DHF 3DKJ 3DKL
Descriptor	Nicotinamide phosphoribosyltransferase, MAGNESIUM ION, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, ... (5 entities in total)
Functional Keywords	transferase, nmprtase, namprtase, visfatin, nmn, nicotinamide d-ribonucleotide, pyrophosphate, alternative splicing, cytoplasm, glycosyltransferase, phosphoprotein, polymorphism, pyridine nucleotide biosynthesis
Biological source	Homo sapiens
Cellular location	Nucleus : P43490
Total number of polymer chains	2
Total formula weight	110729.81
Authors	Ho, M.,Burgos, E.S.,Almo, S.C.,Schramm, V.L. (deposition date: 2008-06-17, release date: 2009-08-18, Last modification date: 2023-08-30)
Primary citation	Burgos, E.S.,Ho, M.C.,Almo, S.C.,Schramm, V.L. A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proc.Natl.Acad.Sci.USA, 106:13748-13753, 2009 Cited by PubMed: 19666527 DOI: 10.1073/pnas.0903898106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation