3DHD
Crystal structure of human NAMPT complexed with nicotinamide mononucleotide and pyrophosphate
Summary for 3DHD
Entry DOI | 10.2210/pdb3dhd/pdb |
Related | 3DGR 3DHF 3DKJ 3DKL |
Descriptor | Nicotinamide phosphoribosyltransferase, MAGNESIUM ION, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, ... (5 entities in total) |
Functional Keywords | transferase, nmprtase, namprtase, visfatin, nmn, nicotinamide d-ribonucleotide, pyrophosphate, alternative splicing, cytoplasm, glycosyltransferase, phosphoprotein, polymorphism, pyridine nucleotide biosynthesis |
Biological source | Homo sapiens |
Cellular location | Nucleus : P43490 |
Total number of polymer chains | 2 |
Total formula weight | 110729.81 |
Authors | Ho, M.,Burgos, E.S.,Almo, S.C.,Schramm, V.L. (deposition date: 2008-06-17, release date: 2009-08-18, Last modification date: 2023-08-30) |
Primary citation | Burgos, E.S.,Ho, M.C.,Almo, S.C.,Schramm, V.L. A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proc.Natl.Acad.Sci.USA, 106:13748-13753, 2009 Cited by PubMed: 19666527DOI: 10.1073/pnas.0903898106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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