3DKL

Crystal structure of phosphorylated mimic form of human NAMPT complexed with benzamide and phosphoribosyl pyrophosphate

Summary for 3DKL

Entry DOI	10.2210/pdb3dkl/pdb
Related	3DGR 3DHD 3DHF 3DKJ
Descriptor	Nicotinamide phosphoribosyltransferase, MAGNESIUM ION, BENZAMIDE, ... (6 entities in total)
Functional Keywords	transferase, nmprtase, visfatin, nicotinamide phosphoribosyltransferase, beryllium fluoride, benzamide, phosphoribosyl pyrophosphate, alternative splicing, cytoplasm, glycosyltransferase, phosphoprotein, polymorphism, pyridine nucleotide biosynthesis
Biological source	Homo sapiens
Total number of polymer chains	2
Total formula weight	110861.87
Authors	Ho, M.,Burgos, E.S.,Almo, S.C.,Schramm, V.L. (deposition date: 2008-06-25, release date: 2009-08-18, Last modification date: 2023-08-30)
Primary citation	Burgos, E.S.,Ho, M.C.,Almo, S.C.,Schramm, V.L. A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proc.Natl.Acad.Sci.USA, 106:13748-13753, 2009 Cited by PubMed: 19666527 DOI: 10.1073/pnas.0903898106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation