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8G8N	CTLA4 Fab with peptide Descriptor: CYS-PRO-GLY-LYS-GLY-LEU-PRO-SER-CYS, Fab heavy chain, Fab light chain Authors: Williams, J.C. Deposit date: 2023-02-18 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (3 Å) Cite: XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer. J Immunother Cancer, 11, 2023
3S0X	The crystal structure of GxGD membrane protease FlaK Descriptor: Peptidase A24B, FlaK domain protein Authors: Hu, J, Xue, Y, Ha, Y. Deposit date: 2011-05-13 Release date: 2011-08-03 Method: X-RAY DIFFRACTION (3.6 Å) Cite: The crystal structure of GXGD membrane protease FlaK. Nature, 475, 2011
5XXZ	Crystal structure of a serine protease from Streptococcus species Descriptor: CALCIUM ION, Chemokine protease C, SULFATE ION Authors: Jobichen, C, Sivaraman, J. Deposit date: 2017-07-05 Release date: 2018-08-08 Last modified: 2018-09-26 Method: X-RAY DIFFRACTION (3.085 Å) Cite: Structure of ScpC, a virulence protease fromStreptococcus pyogenes, reveals the functional domains and maturation mechanism. Biochem. J., 475, 2018
6GUS	CRYSTAL STRUCTURE OF PROTEIN E FROM NON-TYPEABLE HAEMOPHILUS INFLUENZAE Descriptor: CHLORIDE ION, GLYCEROL, SULFATE ION, ... Authors: Somers, D. Deposit date: 2018-06-19 Release date: 2019-05-29 Last modified: 2019-07-31 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Design and Characterization of Protein E-PilA, a Candidate Fusion Antigen for Nontypeable Haemophilus influenzae Vaccine. Infect.Immun., 87, 2019
1GRN	CRYSTAL STRUCTURE OF THE CDC42/CDC42GAP/ALF3 COMPLEX. Descriptor: ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Nassar, N, Hoffman, G.R, Clardy, J.C, Cerione, R.A. Deposit date: 1998-07-30 Release date: 1999-12-22 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP. Nat.Struct.Biol., 5, 1998
1GZS	CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE GEF DOMAIN OF THE SALMONELLA TYPHIMURIUM SOPE TOXIN AND HUMAN Cdc42 Descriptor: GTP-BINDING PROTEIN, SOPE, SULFATE ION Authors: Buchwald, G, Friebel, A, Galan, J.E, Hardt, W.D, Wittinghofer, A, Scheffzek, K. Deposit date: 2002-06-05 Release date: 2002-09-12 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural Basis for the Reversible Activation of a Rho Protein by the Bacterial Toxin Sope Embo J., 21, 2002
4DID	Crystal structure of Salmonella effector N-terminal domain SopB in complex with Cdc42 Descriptor: Cell division control protein 42 homolog, GUANOSINE-5'-DIPHOSPHATE, Inositol phosphate phosphatase sopB, ... Authors: Burkinshaw, B.J, Strynadka, N.C.J. Deposit date: 2012-01-30 Release date: 2012-02-29 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.3501 Å) Cite: Structure of Salmonella Effector Protein SopB N-terminal Domain in Complex with Host Rho GTPase Cdc42. J.Biol.Chem., 287, 2012
2KNQ	Solution structure of E.Coli GspH Descriptor: General secretion pathway protein H Authors: Zhang, Y, Jin, C. Deposit date: 2009-08-31 Release date: 2010-09-08 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Solution structure of GspH To be Published
2KB0	Cdc42(T35A) Descriptor: Cell division control protein 42 homolog Authors: Adams, P.D, Oswald, R.E, McFeeters, R. Deposit date: 2008-11-18 Release date: 2009-12-01 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Cdc42(T35A) To be Published
7T4Q	CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with neutralizing fabs 2C12, 7I13 and 13H11 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein H, Envelope glycoprotein L, ... Authors: Kschonsak, M, Johnson, M.C, Schelling, R, Green, E.M, Rouge, L, Ho, H, Patel, N, Kilic, C, Kraft, E, Arthur, C.P, Rohou, A.L, Comps-Agrar, L, Martinez-Martin, N, Perez, L, Payandeh, J, Ciferri, C. Deposit date: 2021-12-10 Release date: 2022-03-23 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural basis for HCMV Pentamer receptor recognition and antibody neutralization. Sci Adv, 8, 2022
7T4R	CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with THBD and neutralizing fabs MSL-109 and 13H11 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein H, Envelope glycoprotein L, ... Authors: Kschonsak, M, Johnson, M.C, Schelling, R, Green, E.M, Rouge, L, Ho, H, Patel, N, Kilic, C, Kraft, E, Arthur, C.P, Rohou, A.L, Comps-Agrar, L, Martinez-Martin, N, Perez, L, Payandeh, J, Ciferri, C. Deposit date: 2021-12-10 Release date: 2022-03-23 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural basis for HCMV Pentamer receptor recognition and antibody neutralization. Sci Adv, 8, 2022
1AM4	COMPLEX BETWEEN CDC42HS.GMPPNP AND P50 RHOGAP (H. SAPIENS) Descriptor: CDC42HS, MAGNESIUM ION, P50-RHOGAP, ... Authors: Rittinger, K, Walker, P, Gamblin, S.J, Smerdon, S.J. Deposit date: 1997-06-22 Release date: 1998-07-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP. Nature, 388, 1997
1CEE	SOLUTION STRUCTURE OF CDC42 IN COMPLEX WITH THE GTPASE BINDING DOMAIN OF WASP Descriptor: GTP-BINDING RHO-LIKE PROTEIN, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... Authors: Abdul-Manan, N, Aghazadeh, B, Liu, G.A, Majumdar, A, Ouerfelli, O, Rosen, M.K. Deposit date: 1999-03-08 Release date: 1999-06-30 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein. Nature, 399, 1999
1A4R	G12V MUTANT OF HUMAN PLACENTAL CDC42 GTPASE IN THE GDP FORM Descriptor: AMINOPHOSPHONIC ACID-GUANYLATE ESTER, G25K GTP-BINDING PROTEIN, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Rudolph, M.G, Vetter, I.R, Wittinghofer, A. Deposit date: 1998-02-02 Release date: 1999-03-02 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Nucleotide binding to the G12V-mutant of Cdc42 investigated by X-ray diffraction and fluorescence spectroscopy: two different nucleotide states in one crystal. Protein Sci., 8, 1999
1DOA	Structure of the rho family gtp-binding protein cdc42 in complex with the multifunctional regulator rhogdi Descriptor: GERAN-8-YL GERAN, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Hoffman, G.R, Nassar, N, Cerione, R.C. Deposit date: 1999-12-20 Release date: 2000-02-09 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI. Cell(Cambridge,Mass.), 100, 2000
1AN0	CDC42HS-GDP COMPLEX Descriptor: CDC42HS-GDP, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION Authors: Kongsaeree, P, Cerione, R, Clardy, J. Deposit date: 1997-06-26 Release date: 1999-01-13 Last modified: 2021-11-03 Method: X-RAY DIFFRACTION (2.8 Å) Cite: The Structure Determination of Cdc42Hs and Gdp Complex To be Published
1EES	SOLUTION STRUCTURE OF CDC42HS COMPLEXED WITH A PEPTIDE DERIVED FROM P-21 ACTIVATED KINASE, NMR, 20 STRUCTURES Descriptor: GTP-BINDING PROTEIN, P21-ACTIVATED KINASE Authors: Gizachew, D, Guo, W, Chohan, K.C, Sutcliffe, M.J, Oswald, R.E. Deposit date: 2000-02-02 Release date: 2000-03-29 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Structure of the complex of Cdc42Hs with a peptide derived from P-21 activated kinase. Biochemistry, 39, 2000
1E0A	Cdc42 complexed with the GTPase binding domain of p21 activated kinase Descriptor: Cell division control protein 42 homolog, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... Authors: Morreale, A, Venkatesan, M, Mott, H.R, Owen, D, Nietlispach, D, Lowe, P.N, Laue, E.D. Deposit date: 2000-03-16 Release date: 2000-04-18 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Solution Structure of Cdc42 Bound to the Gtpase Binding Domian of Pak Nat.Struct.Biol., 7, 2000
6ZS5	3.5 A cryo-EM structure of human uromodulin filament core Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Uromodulin, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Authors: Stanisich, J.J, Zyla, D, Afanasyev, P, Xu, J, Pilhofer, M, Boeringer, D, Glockshuber, R. Deposit date: 2020-07-15 Release date: 2020-09-02 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism. Elife, 9, 2020
1AJE	CDC42 FROM HUMAN, NMR, 20 STRUCTURES Descriptor: CDC42HS Authors: Feltham, J.L, Dotsch, V, Raza, S, Manor, D, Cerione, R.A, Sutcliffe, M.J, Wagner, G, Oswald, R.E. Deposit date: 1997-05-02 Release date: 1997-11-12 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Definition of the switch surface in the solution structure of Cdc42Hs. Biochemistry, 36, 1997
6ZYA	Extended human uromodulin filament core at 3.5 A resolution Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Uromodulin, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Authors: Stanisich, J.J, Zyla, D, Afanasyev, P, Xu, J, Pilhofer, M, Boeringer, D, Glockshuber, R. Deposit date: 2020-07-31 Release date: 2020-09-02 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism. Elife, 9, 2020
1CF4	CDC42/ACK GTPASE-BINDING DOMAIN COMPLEX Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, PROTEIN (ACTIVATED P21CDC42HS KINASE), ... Authors: Mott, H.R, Owen, D, Nietlispach, D, Lowe, P.N, Lim, L, Laue, E.D. Deposit date: 1999-03-23 Release date: 1999-06-18 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK. Nature, 399, 1999
6SIU	Crystal structure of IbpAFic2 covalently tethered to Cdc42 Descriptor: Cell division control protein 42 homolog, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Gulen, B, Roselin, M, Albers, M, Hedberg, C, Itzen, A, Pogenberg, V. Deposit date: 2019-08-12 Release date: 2020-03-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.49 Å) Cite: Identification of targets of AMPylating Fic enzymes by co-substrate-mediated covalent capture. Nat.Chem., 12, 2020
2BH1	X-ray structure of the general secretion pathway complex of the N- terminal domain of EpsE and the cytosolic domain of EpsL of Vibrio cholerae Descriptor: CALCIUM ION, GENERAL SECRETION PATHWAY PROTEIN E,, GENERAL SECRETION PATHWAY PROTEIN L Authors: Abendroth, J, Murphy, P.M, Mushtaq, A, Bagdasarian, M, Sandkvist, M, Hol, W.G.J. Deposit date: 2005-01-06 Release date: 2005-05-13 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The X-Ray Structure of the Type II Secretion System Complex Formed by the N-Terminal Domain of Epse and the Cytoplasmic Domain of Epsl of Vibrio Cholerae J.Mol.Biol., 348, 2005
3EG5	Crystal structure of MDIA1-TSH GBD-FH3 in complex with CDC42-GMPPNP Descriptor: Cell division control protein 42 homolog, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... Authors: Lammers, M, Meyer, S, Kuehlmann, D, Wittinghofer, A. Deposit date: 2008-09-10 Release date: 2008-10-14 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Specificity of Interactions between mDia Isoforms and Rho Proteins J.Biol.Chem., 283, 2008

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