3EG5

Crystal structure of MDIA1-TSH GBD-FH3 in complex with CDC42-GMPPNP

Summary for 3EG5

Entry DOI	10.2210/pdb3eg5/pdb
Related	1Z2C 2BAP
Descriptor	Cell division control protein 42 homolog, Protein diaphanous homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (5 entities in total)
Functional Keywords	protein-protein complex, rho proteins, diaphanous, formins, armadillo repeat, g-protein, gtpase, alternative splicing, cell membrane, gtp-binding, lipoprotein, membrane, methylation, nucleotide-binding, prenylation, actin-binding, cell projection, coiled coil, cytoplasm, cytoskeleton, phosphoprotein, ubl conjugation, signaling protein
Biological source	Mus musculus (mouse) More
Cellular location	Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P60766 Cell membrane: O08808
Total number of polymer chains	4
Total formula weight	129099.80
Authors	Lammers, M.,Meyer, S.,Kuehlmann, D.,Wittinghofer, A. (deposition date: 2008-09-10, release date: 2008-10-14, Last modification date: 2023-11-01)
Primary citation	Lammers, M.,Meyer, S.,Kuhlmann, D.,Wittinghofer, A. Specificity of Interactions between mDia Isoforms and Rho Proteins J.Biol.Chem., 283:35236-35246, 2008 Cited by PubMed: 18829452 DOI: 10.1074/jbc.M805634200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation