6V8Z
 
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6UOE
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1J1P
 | | Crystal structure of HyHEL-10 Fv mutant LS91A complexed with hen egg white lysozyme | | Descriptor: | Ig VH,anti-lysozyme, Lysozyme C, lysozyme binding Ig kappa chain V23-J2 region | | Authors: | Yokota, A, Tsumoto, K, Shiroishi, M, Kondo, H, Kumagai, I. | | Deposit date: | 2002-12-13 | | Release date: | 2003-01-14 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The Role of Hydrogen Bonding via Interfacial Water Molecules in Antigen-Antibody Complexation. THE HyHEL-10-HEL INTERACTION
J.BIOL.CHEM., 278, 2003
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6UTA
 | | Crystal structure of Z004 iGL Fab in complex with ZIKV EDIII | | Descriptor: | Env, Z004 iGL Fab heavy chain, Z004 iGL Fab light chain | | Authors: | Esswein, S.R, Gristick, H.B, Keeffe, J.R, Bjorkman, P.J. | | Deposit date: | 2019-10-29 | | Release date: | 2020-04-15 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural basis for Zika envelope domain III recognition by a germline version of a recurrent neutralizing antibody.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6V80
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7XMF
 | | Cryo-EM structure of human NaV1.7/beta1/beta2-Nav1.7-IN2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[[4-[3-(4-fluoranyl-2-methyl-phenoxy)azetidin-1-yl]pyrimidin-2-yl]amino]-~{N}-methyl-benzamide, ... | | Authors: | Zhang, J.T, Jiang, D.H. | | Deposit date: | 2022-04-25 | | Release date: | 2022-11-30 | | Last modified: | 2022-12-28 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | Structural basis for Na V 1.7 inhibition by pore blockers.
Nat.Struct.Mol.Biol., 29, 2022
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7XMG
 | | Cryo-EM structure of human NaV1.7/beta1/beta2-TCN-1752 | | Descriptor: | (1~{Z})-~{N}-[2-methyl-3-[(~{E})-[6-[4-[[4-(trifluoromethyloxy)phenyl]methoxy]piperidin-1-yl]-1~{H}-1,3,5-triazin-2-ylidene]amino]phenyl]ethanimidic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Jiang, D.H, Zhang, J.T. | | Deposit date: | 2022-04-25 | | Release date: | 2022-11-30 | | Last modified: | 2022-12-28 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Structural basis for Na V 1.7 inhibition by pore blockers.
Nat.Struct.Mol.Biol., 29, 2022
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7XM9
 | | Cryo-EM structure of human NaV1.7/beta1/beta2-XEN907 | | Descriptor: | (7~{R})-1'-pentylspiro[6~{H}-furo[3,2-f][1,3]benzodioxole-7,3'-indole]-2'-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | zhang, J.T, Jiang, D.H. | | Deposit date: | 2022-04-25 | | Release date: | 2022-11-30 | | Last modified: | 2022-12-28 | | Method: | ELECTRON MICROSCOPY (3.22 Å) | | Cite: | Structural basis for Na V 1.7 inhibition by pore blockers.
Nat.Struct.Mol.Biol., 29, 2022
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7XAD
 | | Crystal strucutre of PD-L1 and DBL2_02 designed protein binder | | Descriptor: | DBL2_02 binder, Programmed cell death 1 ligand 1 | | Authors: | Liu, K.F, Xu, Z.P, Han, P, Pacesa, M, Gao, G.F, Chai, Y, Tan, S.G. | | Deposit date: | 2022-03-17 | | Release date: | 2023-04-12 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | De novo design of protein interactions with learned surface fingerprints.
Nature, 617, 2023
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6V8X
 | | VRC01 Bound BG505 F14 HIV-1 SOSIP Envelope Trimer Structure | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | | Authors: | Henderson, R, Acharya, P. | | Deposit date: | 2019-12-12 | | Release date: | 2020-02-05 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements.
Nat Commun, 11, 2020
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1I9I
 | | NATIVE CRYSTAL STRUCTURE OF THE RECOMBINANT MONOCLONAL WILD TYPE ANTI-TESTOSTERONE FAB FRAGMENT | | Descriptor: | RECOMBINANT MONOCLONAL ANTI-TESTOSTERONE FAB FRAGMENT HEAVY CHAIN, RECOMBINANT MONOCLONAL ANTI-TESTOSTERONE FAB FRAGMENT LIGHT CHAIN | | Authors: | Valjakka, J, Takkinenz, K, Teerinen, T, Soderlund, H, Rouvinen, J. | | Deposit date: | 2001-03-20 | | Release date: | 2002-03-20 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.72 Å) | | Cite: | Structural insights into steroid hormone binding: the crystal structure of a recombinant anti-testosterone Fab fragment in free and testosterone-bound forms.
J.Biol.Chem., 277, 2002
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1IC5
 | | CRYSTAL STRUCTURE OF HYHEL-10 FV MUTANT(HD99A)-HEN LYSOZYME COMPLEX | | Descriptor: | IGG1 FAB CHAIN H, LYSOZYME BINDING IG KAPPA CHAIN, LYSOZYME C | | Authors: | Shiroishi, M, Yokota, A, Tsumoto, K, Kondo, H, Nishimiya, Y, Horii, K, Matsushima, M, Ogasahara, K, Yutani, K, Kumagai, I. | | Deposit date: | 2001-03-30 | | Release date: | 2001-07-18 | | Last modified: | 2021-11-10 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural evidence for entropic contribution of salt bridge formation to a protein antigen-antibody interaction: the case of hen lysozyme-HyHEL-10 Fv complex.
J.Biol.Chem., 276, 2001
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1I9J
 | | TESTOSTERONE COMPLEX STRUCTURE OF THE RECOMBINANT MONOCLONAL WILD TYPE ANTI-TESTOSTERONE FAB FRAGMENT | | Descriptor: | RECOMBINANT MONOCLONAL ANTI-TESTOSTERONE FAB FRAGMENT HEAVY CHAIN, RECOMBINANT MONOCLONAL ANTI-TESTOSTERONE FAB FRAGMENT LIGHT CHAIN, TESTOSTERONE | | Authors: | Valjakka, J, Takkinenz, K, Teerinen, T, Soderlund, H, Rouvinen, J. | | Deposit date: | 2001-03-20 | | Release date: | 2002-03-20 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural insights into steroid hormone binding: the crystal structure of a recombinant anti-testosterone Fab fragment in free and testosterone-bound forms.
J.Biol.Chem., 277, 2002
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7XT6
 | | Structure of a membrane protein M3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, B-cell antigen receptor complex-associated protein alpha chain, ... | | Authors: | Ma, X, Zhu, Y, Chen, Y, Huang, Z. | | Deposit date: | 2022-05-16 | | Release date: | 2022-08-31 | | Method: | ELECTRON MICROSCOPY (3.63 Å) | | Cite: | Cryo-EM structures of two human B cell receptor isotypes.
Science, 377, 2022
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7XXL
 | | RBD in complex with Fab14 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab14 heavy chain, Fab14 light chain, ... | | Authors: | Lin, J.Q, Tan, Y.J.E, Wu, B, Lescar, J. | | Deposit date: | 2022-05-30 | | Release date: | 2022-09-14 | | Last modified: | 2022-10-05 | | Method: | ELECTRON MICROSCOPY (7.3 Å) | | Cite: | Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth.
Nat Commun, 13, 2022
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1I8M
 | | CRYSTAL STRUCTURE OF A RECOMBINANT ANTI-SINGLE-STRANDED DNA ANTIBODY FRAGMENT COMPLEXED WITH DT5 | | Descriptor: | 5'-D(*TP*TP*TP*TP*T)-3', 5'-D(P*TP*T)-3', ANTIBODY HEAVY CHAIN FAB, ... | | Authors: | Tanner, J.J, Komissarov, A.A, Deutscher, S.L. | | Deposit date: | 2001-03-14 | | Release date: | 2001-12-07 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structure of an Antigen-Binding Fragment Bound to Single-Stranded DNA
J.Mol.Biol., 314, 2001
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6VRK
 | | Cryo-EM structure of the wild-type human serotonin transporter complexed with Br-paroxetine and 8B6 Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody, heavy chain, ... | | Authors: | Coleman, J.A, Navratna, V, Yang, D. | | Deposit date: | 2020-02-07 | | Release date: | 2020-03-11 | | Last modified: | 2020-09-23 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Chemical and structural investigation of the paroxetine-human serotonin transporter complex.
Elife, 9, 2020
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7XVE
 | | Human Nav1.7 mutant class-I | | Descriptor: | (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | | Authors: | Huang, G, Wu, Q, Li, Z, Pan, X, Yan, N. | | Deposit date: | 2022-05-21 | | Release date: | 2022-08-10 | | Last modified: | 2023-03-01 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Na v 1.7.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7XVF
 | | Nav1.7 mutant class2 | | Descriptor: | (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | | Authors: | Huang, G, Wu, Q, Li, Z, Pan, X, Yan, N. | | Deposit date: | 2022-05-22 | | Release date: | 2022-08-10 | | Last modified: | 2023-03-01 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Na v 1.7.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7XQ8
 | | Structure of human B-cell antigen receptor of the IgM isotype | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, B-cell antigen receptor complex-associated protein alpha chain, B-cell antigen receptor complex-associated protein beta chain, ... | | Authors: | Chen, M.Y, Su, Q, Shi, Y.G. | | Deposit date: | 2022-05-07 | | Release date: | 2022-08-17 | | Last modified: | 2022-08-31 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structure of the human IgM B cell receptor.
Science, 377, 2022
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1H3P
 | | STRUCTURAL CHARACTERISATION OF A MONOCLONAL ANTIBODY SPECIFIC FOR THE PRES1 REGION OF THE HEPATITIS B VIRUS | | Descriptor: | ANTIBODY FAB FRAGMENT | | Authors: | Pizarro, J.C, Vulliez-Le-normand, B, Riottot, M.M, Budkowska, A, Bentley, G.A. | | Deposit date: | 2002-09-12 | | Release date: | 2002-09-19 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural and Functional Characterisation of a Monoclonal Antibody Specific for the Pres1 Region of Hepatitis B Virus
FEBS Lett., 509, 2001
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6VRH
 | | Cryo-EM structure of the wild-type human serotonin transporter complexed with paroxetine and 8B6 Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody, heavy chain, ... | | Authors: | Coleman, J.A, Navratna, V, Yang, D. | | Deposit date: | 2020-02-07 | | Release date: | 2020-03-11 | | Last modified: | 2020-09-23 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Chemical and structural investigation of the paroxetine-human serotonin transporter complex.
Elife, 9, 2020
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6UE9
 | | Structure of tetrameric sIgA complex (Class 2) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin J chain, ... | | Authors: | Kumar, N, Arthur, C.P, Ciferri, C, Matsumoto, M.L. | | Deposit date: | 2019-09-20 | | Release date: | 2020-02-19 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structure of the secretory immunoglobulin A core.
Science, 367, 2020
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6UGV
 | | Crystal structure of the Fab fragment of anti-TNFa antibody infliximab (Remicade) in a I-centered orthorhombic crystal form, Lot C | | Descriptor: | 1,2-ETHANEDIOL, Infliximab Fab Heavy Chain, Infliximab Fab Light Chain, ... | | Authors: | Lerch, T.F, Sharpe, P, Mayclin, S.J, Edwards, T.E, Polleck, S, Rouse, J.C, Conlan, H.D. | | Deposit date: | 2019-09-26 | | Release date: | 2019-11-13 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal Structures of PF-06438179/GP1111, an Infliximab Biosimilar.
BioDrugs, 34, 2020
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6UE8
 | | Structure of tetrameric sIgA complex (Class 1) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin J chain, ... | | Authors: | Kumar, N, Arthur, C.P, Ciferri, C, Matsumoto, M.L. | | Deposit date: | 2019-09-20 | | Release date: | 2020-02-19 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structure of the secretory immunoglobulin A core.
Science, 367, 2020
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