PDB: 593 resultsInfo pagesStatus searchChemie searchBIRD

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1ZFP	GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PENTAPEPTIDE Descriptor: EPIDERMAL GROWTH FACTOR RECEPTOR-DERIVED PEPTIDE, GROWTH FACTOR RECEPTOR BINDING PROTEIN, ZINC ION Authors: Rahuel, J. Deposit date: 1998-03-26 Release date: 1999-03-30 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural basis for the high affinity of amino-aromatic SH2 phosphopeptide ligands. J.Mol.Biol., 279, 1998
1Z3K	Structural Insight into the Binding Diversity between the Tyr-Phosphorylated Human EphrinBs and Nck2 SH2 Domain Descriptor: Cytoplasmic protein NCK2 Authors: Ran, X, Song, J. Deposit date: 2005-03-14 Release date: 2005-03-29 Last modified: 2022-03-02 Method: SOLUTION NMR Cite: Structural insight into the binding diversity between the Tyr-phosphorylated human ephrinBs and Nck2 SH2 domain. J.Biol.Chem., 280, 2005
2AOA	Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain Descriptor: 2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, Growth factor receptor-bound protein 2 Authors: Phan, J, Shi, Z.D, Burke, T.R, Waugh, D.S. Deposit date: 2005-08-12 Release date: 2005-10-04 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Crystal Structures of a High-affinity Macrocyclic Peptide Mimetic in Complex with the Grb2 SH2 Domain. J.Mol.Biol., 353, 2005
2AUG	Crystal structure of the Grb14 SH2 domain Descriptor: Growth factor receptor-bound protein 14 Authors: Depetris, R.S, Hu, J, Gimpelevich, I, Holt, L.J, Daly, R.J, Hubbard, S.R. Deposit date: 2005-08-27 Release date: 2005-11-01 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for inhibition of the insulin receptor by the adaptor protein grb14. Mol.Cell, 20, 2005
2AOB	Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain Descriptor: 2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID, Growth factor receptor-bound protein 2 Authors: Phan, J, Shi, Z.D, Burke, T.R, Waugh, D.S. Deposit date: 2005-08-12 Release date: 2005-10-04 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal Structures of a High-affinity Macrocyclic Peptide Mimetic in Complex with the Grb2 SH2 Domain. J.Mol.Biol., 353, 2005
5X94	Crystal structure of SHP2_SH2-CagA EPIYA_D peptide complex Descriptor: Cag pathogenicity island protein, Tyrosine-protein phosphatase non-receptor type 11 Authors: Senda, M, Senda, T. Deposit date: 2017-03-05 Release date: 2017-09-13 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins. Cell Rep, 20, 2017
3OV1	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: FORMIC ACID, GLYCEROL, Growth factor receptor-bound protein 2, ... Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-09-15 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3OVE	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, PYAC7CN Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-09-16 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3PSJ	Crystal Structure of the Spt6 Tandem SH2 Domain from Saccharomyces cerevisiae, Form Se-Spt6 (1247-1451) Descriptor: SULFATE ION, Transcription elongation factor SPT6 Authors: Close, D, Hill, C.P. Deposit date: 2010-12-01 Release date: 2011-03-30 Last modified: 2017-11-08 Method: X-RAY DIFFRACTION (2.702 Å) Cite: Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011
3PQZ	Grb7 SH2 with peptide Descriptor: Growth factor receptor-bound protein 7, cyclic peptide Authors: Wilce, J.A. Deposit date: 2010-11-29 Release date: 2011-07-20 Last modified: 2011-09-21 Method: X-RAY DIFFRACTION (2.413 Å) Cite: Structural basis of binding by cyclic nonphosphorylated Peptide antagonists of grb7 implicated in breast cancer progression J.Mol.Biol., 412, 2011
3PSK	Crystal Structure of the Spt6 Tandem SH2 Domain from Saccharomyces cerevisiae, Form Native Spt6 (1247-1451) Descriptor: SULFATE ION, Transcription elongation factor SPT6 Authors: Close, D, Hill, C.P. Deposit date: 2010-12-01 Release date: 2011-03-30 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011
4P9V	Grb2 SH2 complexed with a pTyr-Ac6cN-Asn tripeptide Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, PHQ-PTR-02K-ASN-NH2 Authors: Clements, J.H, Martin, S.F. Deposit date: 2014-04-06 Release date: 2014-06-18 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Protein-ligand interactions: Probing the energetics of a putative cation-pi interaction. Bioorg.Med.Chem.Lett., 24, 2014
4P9Z	Grb2 SH2 complexed with a pTyr-Ac6c-Asn tripeptide Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ... Authors: Clements, J.H, Martin, S.F. Deposit date: 2014-04-06 Release date: 2014-06-18 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Protein-ligand interactions: Probing the energetics of a putative cation-pi interaction. Bioorg.Med.Chem.Lett., 24, 2014
3S8N	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: CHLORIDE ION, GLYCEROL, Growth factor receptor-bound protein 2, ... Authors: Clements, J.H, Stephen, F.M. Deposit date: 2011-05-29 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3S9K	Crystal structure of the Itk SH2 domain. Descriptor: CITRIC ACID, Tyrosine-protein kinase ITK/TSK Authors: Joseph, R.E, Ginder, N.D, Hoy, J.A, Nix, J.C, Fulton, B.D, Honzatko, R.B, Andreotti, A.H. Deposit date: 2011-06-01 Release date: 2012-02-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.354 Å) Cite: Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures. Acta Crystallogr.,Sect.F, 68, 2012
3S8L	Protein-Ligand Interactions: Thermodynamic Effects Associated with Increasing Hydrophobic Surface Area Descriptor: CHLORIDE ION, GLYCEROL, Growth factor receptor-bound protein 2, ... Authors: Clements, J.H, Stephen, F.M. Deposit date: 2011-05-29 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3S8O	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, SODIUM ION, ... Authors: Clements, J.H, Stephen, F.M. Deposit date: 2011-05-29 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
4QSY	SHP2 SH2 domain in complex with GAB1 peptide Descriptor: GRB2-associated-binding protein 1, Tyrosine-protein phosphatase non-receptor type 11 Authors: Gogl, G, Remenyi, A. Deposit date: 2014-07-06 Release date: 2015-07-08 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Selective targeting of GAB adapter protein SHP2 tyrosine phosphatase interaction attenuates ERK signaling To be Published
4ROJ	Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide Descriptor: Guanine nucleotide exchange factor VAV2, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION Authors: Liu, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2014-10-28 Release date: 2014-12-10 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide TO BE PUBLISHED
3T04	Crystal structure of monobody 7c12/abl1 sh2 domain complex Descriptor: GLYCEROL, MONOBODY 7C12, SULFATE ION, ... Authors: Wojcik, J.B, Wyrzucki, A.M, Koide, S. Deposit date: 2011-07-19 Release date: 2011-11-23 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis. Cell(Cambridge,Mass.), 147, 2011
3TKZ	Structure of the SHP-2 N-SH2 domain in a 1:2 complex with RVIpYFVPLNR peptide Descriptor: PROTEIN (RVIpYFVPLNR peptide), Tyrosine-protein phosphatase non-receptor type 11 Authors: Zhang, Y, Zhang, J, Yuan, C, Hard, R.L, Park, I.H, Li, C, Bell, C.E, Pei, D. Deposit date: 2011-08-29 Release date: 2011-10-26 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain. Biochemistry, 50, 2011
3TL0	Structure of SHP2 N-SH2 domain in complex with RLNpYAQLWHR peptide Descriptor: RLNpYAQLWHR peptide, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 11 Authors: Zhang, Y, Zhang, J, Yuan, C, Hard, R.L, Park, I.H, Li, C, Bell, C.E, Pei, D. Deposit date: 2011-08-29 Release date: 2011-09-28 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain. Biochemistry, 50, 2011
4TZI	Structure of unliganded Lyn SH2 domain Descriptor: Tyrosine-protein kinase Lyn Authors: Wybenga-Groot, L.E. Deposit date: 2014-07-10 Release date: 2015-01-21 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Tyrosine Phosphorylation of the Lyn Src Homology 2 (SH2) Domain Modulates Its Binding Affinity and Specificity. Mol.Cell Proteomics, 14, 2015
4U1P	Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide Descriptor: Middle T antigen, POLYETHYLENE GLYCOL (N=34), SODIUM ION, ... Authors: Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J. Deposit date: 2014-07-16 Release date: 2015-07-29 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide To Be Published
4U17	Swapped dimer of the human Fyn-SH2 domain Descriptor: 1,2-ETHANEDIOL, PHOSPHATE ION, Tyrosine-protein kinase Fyn Authors: Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J. Deposit date: 2014-07-15 Release date: 2015-07-29 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Swapped dimer of the human Fyn-SH2 domain To Be Published

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