1N7O
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![BU of 1n7o by Molmil](/molmil-images/mine/1n7o) | Streptococcus pneumoniae Hyaluronate Lyase F343V Mutant | Descriptor: | hyaluronidase | Authors: | Nukui, M, Taylor, K.B, McPherson, D.T, Shigenaga, M, Jedrzejas, M.J. | Deposit date: | 2002-11-16 | Release date: | 2002-12-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The function of hydrophobic residues in the catalytic cleft of Streptococcus
pneumoniae hyaluronate lyase. Kinetic characterization of mutant enzyme forms J.Biol.Chem., 278, 2003
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1N7P
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![BU of 1n7p by Molmil](/molmil-images/mine/1n7p) | Streptococcus pneumoniae Hyaluronate Lyase W292A/F343V Double Mutant | Descriptor: | HYALURONIDASE | Authors: | Nukui, M, Taylor, K.B, McPherson, D.T, Shigenaga, M, Jedrzejas, M.J. | Deposit date: | 2002-11-16 | Release date: | 2002-12-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | The function of hydrophobic residues in the catalytic cleft of Streptococcus
pneumoniae hyaluronate lyase. Kinetic characterization of mutant enzyme forms J.Biol.Chem., 278, 2003
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1F9G
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1M02
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![BU of 1m02 by Molmil](/molmil-images/mine/1m02) | NMR Structure of PW2 Bound to SDS Micelles: A Tryptophan-rich Anticocidial Peptide Selected from Phage Display Libraries | Descriptor: | HIS-PRO-LEU-LYS-GLN-TYR-TRP-TRP-ARG-PRO-SER-ILE | Authors: | Tinoco, L.W, da Silva Jr, A, Leite, A, Valente, A.P, Almeida, F.C. | Deposit date: | 2002-06-11 | Release date: | 2002-08-14 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | NMR structure of PW2 bound to SDS micelles. A tryptophan-rich anticoccidial peptide selected from phage display libraries J.Biol.Chem., 277, 2002
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6XRH
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![BU of 6xrh by Molmil](/molmil-images/mine/6xrh) | Salmonella typhimurium tryptophan synthase complexed with oxindolyl-L-alanine and D-glycerol-3-phosphate | Descriptor: | (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-3-[(3S)-2-oxo-2,3-dihydro-1H-indol-3-yl]-L-alanine, 4-[(E)-({1-carboxy-2-[(3S)-2-oxo-2,3-dihydro-1H-indol-3-yl]ethan-1-id-1-yl}iminio)methyl]-2-methyl-5-[(phosphonooxy)methyl]pyridin-1-ium-3-olate, DIMETHYL SULFOXIDE, ... | Authors: | Phillips, R.S. | Deposit date: | 2020-07-12 | Release date: | 2021-02-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Structural Basis of the Stereochemistry of Inhibition of Tryptophan Synthase by Tryptophan and Derivatives. Biochemistry, 60, 2021
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6XT0
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6XNC
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6XOY
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2DW0
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![BU of 2dw0 by Molmil](/molmil-images/mine/2dw0) | Crystal structure of VAP2 from Crotalus atrox venom (Form 2-1 crystal) | Descriptor: | 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, CALCIUM ION, Catrocollastatin, ... | Authors: | Takeda, S, Igarashi, T, Araki, S. | Deposit date: | 2006-08-02 | Release date: | 2007-07-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins Febs Lett., 581, 2007
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2DW1
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![BU of 2dw1 by Molmil](/molmil-images/mine/2dw1) | Crystal structure of VAP2 from Crotalus atrox venom (Form 2-2 crystal) | Descriptor: | 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, CALCIUM ION, Catrocollastatin, ... | Authors: | Takeda, S, Igarashi, T, Araki, S. | Deposit date: | 2006-08-02 | Release date: | 2007-07-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins Febs Lett., 581, 2007
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2E3X
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![BU of 2e3x by Molmil](/molmil-images/mine/2e3x) | Crystal structure of Russell's viper venom metalloproteinase | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, ... | Authors: | Igarashi, T, Takeda, S. | Deposit date: | 2006-11-30 | Release date: | 2007-12-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Crystal structure of RVV-X: an example of evolutionary gain of specificity by ADAM proteinases. Febs Lett., 581, 2007
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7DTV
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![BU of 7dtv by Molmil](/molmil-images/mine/7dtv) | Human Calcium-Sensing Receptor bound with L-Trp and calcium ions | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Ling, S.L, Tian, C.L, Shi, P, Liu, S.L, Meng, X.Y, Liu, L, Sun, D.M, Shi, C.W. | Deposit date: | 2021-01-06 | Release date: | 2021-03-10 | Last modified: | 2021-04-14 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca 2+ ions and L-tryptophan. Cell Res., 31, 2021
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6XAK
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![BU of 6xak by Molmil](/molmil-images/mine/6xak) | Crystal structure of NzeB in complex with cyclo-(L-Trp-L-Pro) and cyclo-(L-Trp-L-Trp) | Descriptor: | (3S,6S)-3,6-bis[(1H-indol-3-yl)methyl]piperazine-2,5-dione, (3S,8aS)-3-(1H-indol-3-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, 1,2-ETHANEDIOL, ... | Authors: | Shende, V.V, Khatri, Y, Newmister, S.A, Sanders, J.N, Lindovska, P, Yu, F, Doyon, T.J, Kim, J, Movassaghi, M, Houk, K.N, Sherman, D.H. | Deposit date: | 2020-06-04 | Release date: | 2021-06-09 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.479 Å) | Cite: | Structure and Function of NzeB, a Versatile C-C and C-N Bond-Forming Diketopiperazine Dimerase. J.Am.Chem.Soc., 142, 2020
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7DTU
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![BU of 7dtu by Molmil](/molmil-images/mine/7dtu) | Human Calcium-Sensing Receptor bound with L-Trp | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Extracellular calcium-sensing receptor, ... | Authors: | Ling, S.L, Tian, C.L, Shi, P, Liu, S.L, Meng, X.Y, Liu, L, Sun, D.M, Shi, C.W. | Deposit date: | 2021-01-06 | Release date: | 2021-03-10 | Last modified: | 2021-04-14 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca 2+ ions and L-tryptophan. Cell Res., 31, 2021
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8AD7
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7QZ5
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8AD8
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![BU of 8ad8 by Molmil](/molmil-images/mine/8ad8) | Flavin-dependent tryptophan 6-halogenase Thal in complex with a D-Trp-Ser dipeptide | Descriptor: | D-tryptophyl-L-serine, GLYCEROL, PHOSPHATE ION, ... | Authors: | Gafe, S, Moritzer, A.C, Montua, N, Sewald, N, Niemann, H.H. | Deposit date: | 2022-07-08 | Release date: | 2022-10-12 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Enzymatic Late-Stage Halogenation of Peptides. Chembiochem, 24, 2023
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7QZ6
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7QZ8
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7QZ7
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7QZ9
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3KT6
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![BU of 3kt6 by Molmil](/molmil-images/mine/3kt6) | Crystal structure of S. cerevisiae tryptophanyl-tRNA synthetase in complex with Trp | Descriptor: | SULFATE ION, TRYPTOPHAN, Tryptophanyl-tRNA synthetase, ... | Authors: | Zhou, M, Dong, X, Zhong, C, Shen, N, Ding, J. | Deposit date: | 2009-11-24 | Release date: | 2010-02-16 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structures of Saccharomyces cerevisiae tryptophanyl-tRNA synthetase: new insights into the mechanism of tryptophan activation and implications for anti-fungal drug design Nucleic Acids Res., 38, 2010
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5TIA
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![BU of 5tia by Molmil](/molmil-images/mine/5tia) | Crystal structure of human TDO in complex with Trp, Northeast Structural Genomics Consortium Target HR6161 | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, TRYPTOPHAN, Tryptophan 2,3-dioxygenase | Authors: | Forouhar, F, Lewis-Ballester, A, Lew, S, Karkashon, S, Seetharaman, J, Yeh, S.R, Tong, L. | Deposit date: | 2016-10-01 | Release date: | 2016-10-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.441 Å) | Cite: | Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase. Sci Rep, 6, 2016
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1UBS
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![BU of 1ubs by Molmil](/molmil-images/mine/1ubs) | TRYPTOPHAN SYNTHASE (E.C.4.2.1.20) WITH A MUTATION OF LYS 87->THR IN THE B SUBUNIT AND IN THE PRESENCE OF LIGAND L-SERINE | Descriptor: | PYRIDOXAL-5'-PHOSPHATE, SERINE, SODIUM ION, ... | Authors: | Rhee, S, Parris, K, Ahmed, S.A, Miles, E.W, Davies, D.R. | Deposit date: | 1995-12-14 | Release date: | 1996-03-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structures of a mutant (betaK87T) tryptophan synthase alpha2beta2 complex with ligands bound to the active sites of the alpha- and beta-subunits reveal ligand-induced conformational changes. Biochemistry, 36, 1997
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5TI9
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![BU of 5ti9 by Molmil](/molmil-images/mine/5ti9) | Crystal structure of human TDO in complex with Trp and dioxygen, Northeast Structural Genomics Consortium Target HR6161 | Descriptor: | N'-Formylkynurenine, OXYGEN MOLECULE, PHOSPHATE ION, ... | Authors: | Forouhar, F, Lewis-Ballester, A, Lew, S, Karkashon, S, Seetharaman, J, Yeh, S.R, Tong, L. | Deposit date: | 2016-10-01 | Release date: | 2016-10-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase. Sci Rep, 6, 2016
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