4JII
Crystal Structure Of AKR1B10 Complexed With NADP+ And Zopolrestat
Summary for 4JII
Entry DOI | 10.2210/pdb4jii/pdb |
Related | 4GQ0 4GQG 4I5X 4JIH 4JIR |
Descriptor | Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, ... (5 entities in total) |
Functional Keywords | tim barrel, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, structural genomics, structural genomics consortium, sgc, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome : O60218 |
Total number of polymer chains | 1 |
Total formula weight | 37483.53 |
Authors | |
Primary citation | Zhang, L.,Zhang, H.,Zhao, Y.,Li, Z.,Chen, S.,Zhai, J.,Chen, Y.,Xie, W.,Wang, Z.,Li, Q.,Zheng, X.,Hu, X. Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111). Febs Lett., 587:3681-3686, 2013 Cited by PubMed: 24100137DOI: 10.1016/j.febslet.2013.09.031 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report