4JII
Crystal Structure Of AKR1B10 Complexed With NADP+ And Zopolrestat
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (X) | Aldo-keto reductase family 1 member B10 | polymer | 318 | 36297.8 | 1 | UniProt (O60218) Pfam (PF00248) | Homo sapiens (human) | ARL-1, Aldose reductase-like, Aldose reductase-related protein, ARP, hARP, Small intestine reductase, SI reductase |
| 2 | B (X) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) PubChem (5885) PubChem (46936685) PubChem (4412) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (71717786) PubChem (165382010) | |||
| 3 | C (X) | 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID | non-polymer | 419.4 | 1 | Chemie (ZST) PubChem (1613) | |||
| 4 | D (X) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 5 | E (X) | water | water | 18.0 | 178 | Chemie (HOH) |
Sequence modifications
X: 1 - 316 (UniProt: O60218)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| Asp 313 | Asn 313 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36297.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1185.8 | |
| All* | Total formula weight | 37483.5 |
