Crystal structure of AKR1B10 complexed with NADP+

Summary for 4GQG

DescriptorAldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total)
Functional Keywordsalpha-beta tim barrel, nadp-dependant oxidoreductase, nadp+, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationLysosome O60218
Total number of polymer chains1
Total molecular weight37041.16
Zhang, L.,Zheng, X.,Chen, S.,Zhai, J.,Hu, X. (deposition date: 2012-08-23, release date: 2013-08-28, Last modification date: 2013-12-11)
Primary citation
Zhang, L.,Zhang, H.,Zhao, Y.,Li, Z.,Chen, S.,Zhai, J.,Chen, Y.,Xie, W.,Wang, Z.,Li, Q.,Zheng, X.,Hu, X.
Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111)
Febs Lett., 587:3681-3686, 2013
PubMed: 24100137 (PDB entries with the same primary citation)
DOI: 10.1016/j.febslet.2013.09.031
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.241400.7%0.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution