4GQG
Crystal structure of AKR1B10 complexed with NADP+
Summary for 4GQG
Entry DOI | 10.2210/pdb4gqg/pdb |
Descriptor | Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total) |
Functional Keywords | alpha-beta tim barrel, nadp-dependant oxidoreductase, nadp+, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: O60218 |
Total number of polymer chains | 1 |
Total formula weight | 37041.16 |
Authors | |
Primary citation | Zhang, L.,Zhang, H.,Zhao, Y.,Li, Z.,Chen, S.,Zhai, J.,Chen, Y.,Xie, W.,Wang, Z.,Li, Q.,Zheng, X.,Hu, X. Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111) Febs Lett., 587:3681-3686, 2013 Cited by PubMed: 24100137DOI: 10.1016/j.febslet.2013.09.031 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.92 Å) |
Structure validation
Download full validation report