8ENX
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8EO0
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8ENS
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8ENW
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8G3C
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8G3E
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![BU of 8g3e by Molmil](/molmil-images/mine/8g3e) | Crystal structure of human WDR5 in complex with (1M)-N-[(3,5-difluoro[1,1'-biphenyl]-4-yl)methyl]-6-methyl-4-oxo-1-(pyridin-3-yl)-1,4-dihydropyridazine-3-carboxamide (compound 2, WDR5-MYC inhibitor) | Descriptor: | (1M)-N-[(3,5-difluoro[1,1'-biphenyl]-4-yl)methyl]-6-methyl-4-oxo-1-(pyridin-3-yl)-1,4-dihydropyridazine-3-carboxamide, WD repeat-containing protein 5 | Authors: | Zhao, M. | Deposit date: | 2023-02-07 | Release date: | 2023-06-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction. J.Med.Chem., 66, 2023
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8FAB
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1NEX
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![BU of 1nex by Molmil](/molmil-images/mine/1nex) | Crystal Structure of ScSkp1-ScCdc4-CPD peptide complex | Descriptor: | CDC4 protein, Centromere DNA-binding protein complex CBF3 subunit D, GLL(TPO)PPQSG | Authors: | Orlicky, S, Tang, X, Willems, A, Tyers, M, Sicheri, F. | Deposit date: | 2002-12-12 | Release date: | 2003-02-18 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Basis for Phosphodependent Substrate Selection and
Orientation by the SCFCdc4 Ubiquitin Ligase Cell(Cambridge,Mass.), 112, 2003
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1NFB
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1KMZ
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![BU of 1kmz by Molmil](/molmil-images/mine/1kmz) | MOLECULAR BASIS OF MITOMYCIN C RESICTANCE IN STREPTOMYCES: CRYSTAL STRUCTURES OF THE MRD PROTEIN WITH AND WITHOUT A DRUG DERIVATIVE | Descriptor: | mitomycin-binding protein | Authors: | Martin, T.W, Dauter, Z, Devedjiev, Y, Sheffield, P, Jelen, F, He, M, Sherman, D, Otlewski, J, Derewenda, Z.S, Derewenda, U. | Deposit date: | 2001-12-17 | Release date: | 2002-07-19 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein. Structure, 10, 2002
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8FN0
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![BU of 8fn0 by Molmil](/molmil-images/mine/8fn0) | CryoEM structure of Go-coupled NTSR1 with a biased allosteric modulator | Descriptor: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Krumm, B.E, DiBerto, J.F, Olsen, R.H.J, Kang, H, Slocum, S.T, Zhang, S, Strachan, R.T, Fay, J.F, Roth, B.L. | Deposit date: | 2022-12-26 | Release date: | 2023-03-29 | Last modified: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator. Biochemistry, 62, 2023
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7WF7
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![BU of 7wf7 by Molmil](/molmil-images/mine/7wf7) | Cryo-EM of Sphingosine 1-phosphate receptor 1 / Gi complex bound to S1P | Descriptor: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | He, Y, Xu, Z. | Deposit date: | 2021-12-26 | Release date: | 2022-01-05 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism. Nat.Chem.Biol., 18, 2022
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8FMZ
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![BU of 8fmz by Molmil](/molmil-images/mine/8fmz) | Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, MiniGq, ... | Authors: | Krumm, B.E, Diberto, J.F, Olsen, R.H.J, Kang, H, Slocum, S.T, Zhang, S, Strachan, R.T, Fay, J.F, Roth, B.L. | Deposit date: | 2022-12-26 | Release date: | 2023-03-29 | Last modified: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (2.59 Å) | Cite: | Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator. Biochemistry, 62, 2023
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8FZQ
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![BU of 8fzq by Molmil](/molmil-images/mine/8fzq) | Dehosphorylated, ATP-bound human cystic fibrosis transmembrane conductance regulator (CFTR) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION | Authors: | Levring, J, Terry, D.S, Kilic, Z, Fitzgerald, G.A, Blanchard, S.C, Chen, J. | Deposit date: | 2023-01-29 | Release date: | 2023-03-29 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | CFTR function, pathology and pharmacology at single-molecule resolution. Nature, 616, 2023
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8FN1
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![BU of 8fn1 by Molmil](/molmil-images/mine/8fn1) | CryoEM structure of Go-coupled NTSR1 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ... | Authors: | Krumm, B.E, DiBerto, J.F, Olsen, R.H.J, Kang, H, Slocum, S.T, Zhang, S, Strachan, R.T, Fay, J.F, Roth, B.L. | Deposit date: | 2022-12-26 | Release date: | 2023-03-29 | Last modified: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (2.88 Å) | Cite: | Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator. Biochemistry, 62, 2023
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7W2Z
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![BU of 7w2z by Molmil](/molmil-images/mine/7w2z) | Cryo-EM structure of the ghrelin-bound human ghrelin receptor-Go complex | Descriptor: | Appetite-regulating hormone, CHOLESTEROL, Growth hormone secretagogue receptor type 1, ... | Authors: | Qin, J, Ming, Q, Ji, S, Mao, C, Shen, D, Zhang, Y. | Deposit date: | 2021-11-24 | Release date: | 2022-01-19 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Molecular mechanism of agonism and inverse agonism in ghrelin receptor. Nat Commun, 13, 2022
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7WB4
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![BU of 7wb4 by Molmil](/molmil-images/mine/7wb4) | Cryo-EM structure of the NR subunit from X. laevis NPC | Descriptor: | GATOR complex protein SEC13, MGC154553 protein, MGC83295 protein, ... | Authors: | Huang, G, Zhan, X, Shi, Y. | Deposit date: | 2021-12-15 | Release date: | 2022-03-02 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (5.6 Å) | Cite: | Cryo-EM structure of the nuclear ring from Xenopus laevis nuclear pore complex. Cell Res., 32, 2022
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2VOA
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![BU of 2voa by Molmil](/molmil-images/mine/2voa) | Structure of an AP Endonuclease from Archaeoglobus fulgidus | Descriptor: | 5'-D(*CP*GP*GP*CP*TP*AP*CP*CP*GP*CP)-3', 5'-D(*GP*CP*GP*GP*TP*AP*GP*CP*CP*GP)-3', EXODEOXYRIBONUCLEASE III | Authors: | Kuettner, E.B, Schmiedel, R, Greiner-Stoffele, T, Strater, N. | Deposit date: | 2008-02-11 | Release date: | 2008-12-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure and Function of the Abasic Site Specificity Pocket of an Ap Endonuclease from Archaeoglobus Fulgidus. DNA Repair, 8, 2009
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8FR8
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![BU of 8fr8 by Molmil](/molmil-images/mine/8fr8) | Structure of Mycobacterium smegmatis Rsh bound to a 70S translation initiation complex | Descriptor: | 16S rRNA (1511-MER), 23S rRNA (3119-MER), 30S ribosomal protein S10, ... | Authors: | Majumdar, S, Sharma, M.R, Manjari, S.R, Banavali, N.K, Agrawal, R.K. | Deposit date: | 2023-01-06 | Release date: | 2023-05-17 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | Starvation sensing by mycobacterial RelA/SpoT homologue through constitutive surveillance of translation. Proc.Natl.Acad.Sci.USA, 120, 2023
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1KMN
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1KMM
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2X2G
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![BU of 2x2g by Molmil](/molmil-images/mine/2x2g) | CRYSTALLOGRAPHIC BINDING STUDIES WITH AN ENGINEERED MONOMERIC VARIANT OF TRIOSEPHOSPHATE ISOMERASE | Descriptor: | 3-PHOSPHOGLYCERIC ACID, TRIOSEPHOSPHATE ISOMERASE, GLYCOSOMAL | Authors: | Salin, M, Kapetaniou, E.G, Vaismaa, M, Lajunen, M, Casteleijn, M.G, Neubauer, P, Salmon, L, Wierenga, R. | Deposit date: | 2010-01-13 | Release date: | 2010-01-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystallographic Binding Studies with an Engineered Monomeric Variant of Triosephosphate Isomerase Acta Crystallogr.,Sect.D, 66, 2010
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2X1U
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![BU of 2x1u by Molmil](/molmil-images/mine/2x1u) | Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase | Descriptor: | SULFATE ION, TRIOSEPHOSPHATE ISOMERASE, GLYCOSOMAL | Authors: | Salin, M, Kapetaniou, E.G, Vaismaa, M, Lajunen, M, Casteleijn, M.G, Neubauer, P, Salmon, L, Wierenga, R. | Deposit date: | 2010-01-04 | Release date: | 2010-01-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Crystallographic Binding Studies with an Engineered Monomeric Variant of Triosephosphate Isomerase Acta Crystallogr.,Sect.D, 66, 2010
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2X1S
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![BU of 2x1s by Molmil](/molmil-images/mine/2x1s) | Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase | Descriptor: | 3-SULFOPROPANOIC ACID, SULFATE ION, TRIOSEPHOSPHATE ISOMERASE, ... | Authors: | Salin, M, Kapetaniou, E.G, Vaismaa, M, Lajunen, M, Castejeijn, M.G, Neubauer, P, Salmon, L, Wierenga, R. | Deposit date: | 2010-01-04 | Release date: | 2010-01-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Crystallographic Binding Studies with an Engineered Monomeric Variant of Triosephosphate Isomerase Acta Crystallogr.,Sect.D, 66, 2010
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1K8C
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![BU of 1k8c by Molmil](/molmil-images/mine/1k8c) | Crystal structure of dimeric xylose reductase in complex with NADP(H) | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, xylose reductase | Authors: | Kavanagh, K.L, Klimacek, M, Nidetzky, B, Wilson, D.K. | Deposit date: | 2001-10-23 | Release date: | 2002-07-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The structure of apo and holo forms of xylose reductase, a dimeric aldo-keto reductase from Candida tenuis. Biochemistry, 41, 2002
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