5ZGP
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![BU of 5zgp by Molmil](/molmil-images/mine/5zgp) | Crystal structure of NDM-1 at pH6.2 (Bis-Tris) in complex with hydrolyzed ampicillin | Descriptor: | (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Zhang, H, Hao, Q. | Deposit date: | 2018-03-10 | Release date: | 2018-08-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother., 62, 2018
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6KNB
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![BU of 6knb by Molmil](/molmil-images/mine/6knb) | PolD-PCNA-DNA (form A) | Descriptor: | DNA polymerase D DP2 (DNA polymerase II large) subunit, DNA polymerase II small subunit, DNA polymerase sliding clamp 1, ... | Authors: | Mayanagi, K, Oki, K, Miyazaki, N, Ishino, S, Yamagami, T, Iwasaki, K, Kohda, D, Morikawa, K, Shirai, T, Ishino, Y. | Deposit date: | 2019-08-05 | Release date: | 2020-08-05 | Last modified: | 2021-02-17 | Method: | ELECTRON MICROSCOPY (6.9 Å) | Cite: | Two conformations of DNA polymerase D-PCNA-DNA, an archaeal replisome complex, revealed by cryo-electron microscopy. Bmc Biol., 18, 2020
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1H8H
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![BU of 1h8h by Molmil](/molmil-images/mine/1h8h) | Bovine mitochondrial F1-ATPase crystallised in the presence of 5mm AMPPNP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, BOVINE MITOCHONDRIAL F1-ATPASE, ... | Authors: | Braig, K, Menz, R.I, Montgomery, M.G, Leslie, A.G.W, Walker, J.E. | Deposit date: | 2001-02-06 | Release date: | 2001-04-15 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The Structure and Nucleotide Occupancy of Bovine Mitochondrial F(1)-ATPase are not Influenced by Crystallisation at High Concentrations of Nucleotide FEBS Lett., 494, 2001
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1LOE
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1ZYU
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![BU of 1zyu by Molmil](/molmil-images/mine/1zyu) | Crystal structure of Mycobacterium tuberculosis shikimate kinase in complex with shikimate and amppcp at 2.85 angstrom resolution | Descriptor: | (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Shikimate kinase | Authors: | Gan, J.H, Gu, Y.J, Li, Y, Yan, H.G, Ji, X. | Deposit date: | 2005-06-11 | Release date: | 2006-07-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal Structure of Mycobacterium tuberculosis Shikimate Kinase in Complex with Shikimic Acid and an ATP Analogue Biochemistry, 45, 2006
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1R7E
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![BU of 1r7e by Molmil](/molmil-images/mine/1r7e) | NMR structure of the membrane anchor domain (1-31) of the nonstructural protein 5A (NS5A) of hepatitis C virus (Minimized average structure. Sample in 100mM SDS). | Descriptor: | Genome polyprotein | Authors: | Penin, F, Brass, V, Appel, N, Ramboarina, S, Montserret, R, Ficheux, D, Blum, H.E, Bartenschlager, R, Moradpour, D. | Deposit date: | 2003-10-21 | Release date: | 2004-08-10 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A. J.Biol.Chem., 279, 2004
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2DRN
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![BU of 2drn by Molmil](/molmil-images/mine/2drn) | Docking and dimerization domain (D/D) of the Type II-alpha regulatory subunity of protein kinase A (PKA) in complex with a peptide from an A-kinase anchoring protein | Descriptor: | 24-residues peptide from an a-kinase anchoring protein, cAMP-dependent protein kinase type II-alpha regulatory subunit | Authors: | Newlon, M.G, Roy, M, Morikis, D, Hausken, Z.E, Coghlan, V, Scott, J.D, Jennings, P.A. | Deposit date: | 2006-06-11 | Release date: | 2006-08-29 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes. Embo J., 20, 2001
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3DCB
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![BU of 3dcb by Molmil](/molmil-images/mine/3dcb) | Crystal structure of the Drosophila kinesin family member NOD in complex with AMPPNP | Descriptor: | Kinesin-like protein Nod, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Cochran, J.C, Mulko, N.K, Kull, F.J. | Deposit date: | 2008-06-03 | Release date: | 2009-02-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | ATPase cycle of the nonmotile kinesin NOD allows microtubule end tracking and drives chromosome movement. Cell(Cambridge,Mass.), 136, 2009
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2IX2
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![BU of 2ix2 by Molmil](/molmil-images/mine/2ix2) | Crystal structure of the heterotrimeric PCNA from Sulfolobus solfataricus | Descriptor: | DNA POLYMERASE SLIDING CLAMP A, DNA POLYMERASE SLIDING CLAMP B, DNA POLYMERASE SLIDING CLAMP C | Authors: | Williams, G.J, Johnson, K, McMahon, S.A, Carter, L, Oke, M, Liu, H, Taylor, G.L, White, M.F, Naismith, J.H. | Deposit date: | 2006-07-05 | Release date: | 2006-10-04 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of the Heterotrimeric PCNA from Sulfolobus Solfataricus. Acta Crystallogr.,Sect.F, 62, 2006
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4XDP
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![BU of 4xdp by Molmil](/molmil-images/mine/4xdp) | Crystal structure of human KDM4C catalytic domain bound to tris | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | Authors: | Swinger, K.K, Boriack-Sjodin, P.A. | Deposit date: | 2014-12-19 | Release date: | 2015-03-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening. J Biomol Screen, 20, 2015
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4XDO
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![BU of 4xdo by Molmil](/molmil-images/mine/4xdo) | Crystal structure of human KDM4C catalytic domain with OGA | Descriptor: | 1,2-ETHANEDIOL, FE (III) ION, Lysine-specific demethylase 4C, ... | Authors: | Swinger, K.K, Boriack-Sjodin, P.A. | Deposit date: | 2014-12-19 | Release date: | 2015-03-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase Screening. J Biomol Screen, 20, 2015
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4L39
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![BU of 4l39 by Molmil](/molmil-images/mine/4l39) | Crystal structure of GH3.12 from Arabidopsis thaliana in complex with AMPCPP and salicylate | Descriptor: | 2-HYDROXYBENZOIC ACID, 4-substituted benzoates-glutamate ligase GH3.12, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... | Authors: | Zubieta, C, Jez, J.M, Brown, E, Marcellin, R, Kapp, U, Round, A, Westfall, C. | Deposit date: | 2013-06-05 | Release date: | 2013-10-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Determination of the GH3.12 protein conformation through HPLC-integrated SAXS measurements combined with X-ray crystallography. Acta Crystallogr.,Sect.D, 69, 2013
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5AEY
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![BU of 5aey by Molmil](/molmil-images/mine/5aey) | actin-like ParM protein bound to AMPPNP | Descriptor: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PLASMID SEGREGATION PROTEIN PARM | Authors: | Bharat, T.A.M, Murshudov, G.N, Sachse, C, Lowe, J. | Deposit date: | 2015-01-12 | Release date: | 2015-04-22 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structures of Actin-Like Parm Filaments Show Architecture of Plasmid-Segregating Spindles. Nature, 523, 2015
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3CES
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![BU of 3ces by Molmil](/molmil-images/mine/3ces) | Crystal Structure of E.coli MnmG (GidA), a Highly-Conserved tRNA Modifying Enzyme | Descriptor: | tRNA uridine 5-carboxymethylaminomethyl modification enzyme gidA | Authors: | Shi, R, Matte, A, Cygler, M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | Deposit date: | 2008-02-29 | Release date: | 2009-03-03 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.412 Å) | Cite: | Structure-function analysis of Escherichia coli MnmG (GidA), a highly conserved tRNA-modifying enzyme. J.Bacteriol., 191, 2009
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3ZFC
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![BU of 3zfc by Molmil](/molmil-images/mine/3zfc) | Crystal Structure of the Kif4 Motor Domain Complexed With Mg-AMPPNP | Descriptor: | CHROMOSOME-ASSOCIATED KINESIN KIF4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Chang, Q, Nitta, R, Inoue, S, Hirokawa, N. | Deposit date: | 2012-12-11 | Release date: | 2013-03-20 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Basis for the ATP-Induced Isomerization of Kinesin. J.Mol.Biol., 425, 2013
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4L7S
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![BU of 4l7s by Molmil](/molmil-images/mine/4l7s) | Kinase domain mutant of human Itk in complex with an aminobenzothiazole inhibitor | Descriptor: | SULFATE ION, Tyrosine-protein kinase ITK/TSK, trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol | Authors: | Somers, D.O. | Deposit date: | 2013-06-14 | Release date: | 2014-01-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy. ACS Med Chem Lett, 4, 2013
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3CZJ
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![BU of 3czj by Molmil](/molmil-images/mine/3czj) | E. COLI (lacZ) BETA-GALACTOSIDASE (N460T) IN COMPLEX WITH D-GALCTOPYRANOSYL-1-ONE | Descriptor: | Beta-galactosidase, D-galactonolactone, DIMETHYL SULFOXIDE, ... | Authors: | Huber, R.E, Dugdale, M.L, Fraser, M.E, Tammam, S.D. | Deposit date: | 2008-04-29 | Release date: | 2009-04-07 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Practical Considerations When Using Temperature to Obtain Rate Constants and Activation Thermodynamics of Enzymes with Two Catalytic Steps: Native and N460T-beta-Galactosidase (E. coli) as Examples. Protein J., 28, 2009
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3ZFD
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![BU of 3zfd by Molmil](/molmil-images/mine/3zfd) | Crystal Structure of the Kif4 Motor Domain Complexed With Mg-AMPPNP | Descriptor: | CHROMOSOME-ASSOCIATED KINESIN KIF4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Chang, Q, Nitta, R, Inoue, S, Hirokawa, N. | Deposit date: | 2012-12-11 | Release date: | 2013-03-20 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Structural Basis for the ATP-Induced Isomerization of Kinesin. J.Mol.Biol., 425, 2013
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5ZGE
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![BU of 5zge by Molmil](/molmil-images/mine/5zge) | Crystal structure of NDM-1 at pH5.5 (Bis-Tris) in complex with hydrolyzed ampicillin | Descriptor: | (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, HYDROXIDE ION, Metallo-beta-lactamase type 2, ... | Authors: | Zhang, H, Hao, Q. | Deposit date: | 2018-03-08 | Release date: | 2018-08-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1. Antimicrob. Agents Chemother., 62, 2018
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2P5G
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![BU of 2p5g by Molmil](/molmil-images/mine/2p5g) | Crystal structure of RB69 gp43 in complex with DNA with dAMP opposite an abasic site analog in a 21mer template | Descriptor: | DNA polymerase, Primer DNA, Template DNA | Authors: | Zahn, K.E, Belrhali, H, Wallace, S.S, Doublie, S. | Deposit date: | 2007-03-15 | Release date: | 2007-10-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Caught bending the a-rule: crystal structures of translesion DNA synthesis with a non-natural nucleotide. Biochemistry, 46, 2007
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1O4W
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![BU of 1o4w by Molmil](/molmil-images/mine/1o4w) | |
5GV1
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![BU of 5gv1 by Molmil](/molmil-images/mine/5gv1) | Crystal structure of ENZbleach xylanase wild type | Descriptor: | Endo-1,4-beta-xylanase | Authors: | Chitnumsub, P, Jaruwat, A, Boonyapakorn, K, Noytanom, K. | Deposit date: | 2016-09-01 | Release date: | 2017-08-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure-based protein engineering for thermostable and alkaliphilic enhancement of endo-beta-1,4-xylanase for applications in pulp bleaching J. Biotechnol., 259, 2017
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3E3C
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![BU of 3e3c by Molmil](/molmil-images/mine/3e3c) | Structure of GrlR-lipid complex | Descriptor: | (2R)-2-HYDROXY-3-(PHOSPHONOOXY)PROPYL HEXANOATE, L0044 | Authors: | Jobichen, C, Sivaraman, J. | Deposit date: | 2008-08-07 | Release date: | 2009-04-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Identification and characterization of the lipid binding property of GrlR, a locus of enterocyte effacement regulator. Biochem.J., 2009
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3G05
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![BU of 3g05 by Molmil](/molmil-images/mine/3g05) | Crystal structure of N-terminal domain (2-550) of E.coli MnmG | Descriptor: | SULFATE ION, tRNA uridine 5-carboxymethylaminomethyl modification enzyme mnmG | Authors: | Shi, R, Matte, A, Cygler, M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | Deposit date: | 2009-01-27 | Release date: | 2009-10-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.49 Å) | Cite: | Structure-function analysis of Escherichia coli MnmG (GidA), a highly conserved tRNA-modifying enzyme. J.Bacteriol., 191, 2009
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2EB3
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![BU of 2eb3 by Molmil](/molmil-images/mine/2eb3) | Crystal structure of mutated EGFR kinase domain (L858R) in complex with AMPPNP | Descriptor: | Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Yoshikawa, S, Kukimoto-Niino, M, Shirouzu, M, Senba, K, Yamamoto, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-02-06 | Release date: | 2008-02-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.84 Å) | Cite: | Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor Oncogene, 2012
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