2EB3
Crystal structure of mutated EGFR kinase domain (L858R) in complex with AMPPNP
Summary for 2EB3
Entry DOI | 10.2210/pdb2eb3/pdb |
Related | 2EB2 3UG1 3UG2 3VJN 3VJO |
Descriptor | Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER (3 entities in total) |
Functional Keywords | kinase, tyrosine-protein kinase, receptor, transferase, phosphorylation, atp-binding, disease mutation, transmembrane, cell cycle, ec 2.7.10.1, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 1 |
Total formula weight | 38528.16 |
Authors | Yoshikawa, S.,Kukimoto-Niino, M.,Shirouzu, M.,Senba, K.,Yamamoto, T.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2007-02-06, release date: 2008-02-12, Last modification date: 2023-10-25) |
Primary citation | Yoshikawa, S.,Kukimoto-Niino, M.,Parker, L.,Handa, N.,Terada, T.,Fujimoto, T.,Terazawa, Y.,Wakiyama, M.,Sato, M.,Sano, S.,Kobayashi, T.,Tanaka, T.,Chen, L.,Liu, Z.J.,Wang, B.C.,Shirouzu, M.,Kawa, S.,Semba, K.,Yamamoto, T.,Yokoyama, S. Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor Oncogene, 2012 Cited by PubMed: 22349823DOI: 10.1038/onc.2012.21 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.84 Å) |
Structure validation
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