2EB3
Crystal structure of mutated EGFR kinase domain (L858R) in complex with AMPPNP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Epidermal growth factor receptor | polymer | 334 | 38022.0 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (human) | Receptor tyrosine-protein kinase ErbB-1 |
| 2 | A | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 3 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 695 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 689 | - | expression tag |
| Ala 690 | - | expression tag |
| Met 691 | - | expression tag |
| Gly 692 | - | expression tag |
| Ile 693 | - | expression tag |
| Arg 694 | - | expression tag |
| Arg 858 | Leu 858 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38022.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 506.2 | |
| All* | Total formula weight | 38528.2 |
