4L7S
Kinase domain mutant of human Itk in complex with an aminobenzothiazole inhibitor
Summary for 4L7S
Entry DOI | 10.2210/pdb4l7s/pdb |
Related | 4KIO |
Descriptor | Tyrosine-protein kinase ITK/TSK, trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol, SULFATE ION, ... (4 entities in total) |
Functional Keywords | kinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q08881 |
Total number of polymer chains | 2 |
Total formula weight | 61558.13 |
Authors | Somers, D.O. (deposition date: 2013-06-14, release date: 2014-01-22, Last modification date: 2024-02-28) |
Primary citation | Alder, C.M.,Ambler, M.,Campbell, A.J.,Champigny, A.C.,Deakin, A.M.,Harling, J.D.,Harris, C.A.,Longstaff, T.,Lynn, S.,Maxwell, A.C.,Mooney, C.J.,Scullion, C.,Singh, O.M.,Smith, I.E.,Somers, D.O.,Tame, C.J.,Wayne, G.,Wilson, C.,Woolven, J.M. Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy. ACS Med Chem Lett, 4:948-952, 2013 Cited by PubMed: 24900590DOI: 10.1021/ml400206q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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