2UUG
| ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE:INHIBITOR COMPLEX WITH H187D MUTANT UDG AND WILD-TYPE UGI | Descriptor: | URACIL-DNA GLYCOSYLASE, URACIL-DNA GLYCOSYLASE INHIBITOR | Authors: | Putnam, C.D, Arvai, A.S, Mol, C.D, Tainer, J.A. | Deposit date: | 1998-10-31 | Release date: | 1999-03-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase J.Mol.Biol., 287, 1999
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2ZHX
| Crystal structure of Uracil-DNA Glycosylase from Mycobacterium tuberculosis in complex with a proteinaceous inhibitor | Descriptor: | Uracil-DNA glycosylase, Uracil-DNA glycosylase inhibitor | Authors: | Kaushal, P.S, Talawar, R.K, Krishna, P.D.V, Varshney, U, Vijayan, M. | Deposit date: | 2008-02-11 | Release date: | 2008-05-20 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Unique features of the structure and interactions of mycobacterial uracil-DNA glycosylase: structure of a complex of the Mycobacterium tuberculosis enzyme in comparison with those from other sources Acta Crystallogr.,Sect.D, 64, 2008
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3A7N
| Crystal structure of uracil-DNA glycosylase from Mycobacterium tuberculosis | Descriptor: | CITRATE ANION, Uracil-DNA glycosylase | Authors: | Kaushal, P.S, Talawar, R.K, Varshney, U, Vijayan, M. | Deposit date: | 2009-09-29 | Release date: | 2010-08-11 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure of uracil-DNA glycosylase from Mycobacterium tuberculosis: insights into interactions with ligands Acta Crystallogr.,Sect.F, 66, 2010
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3CXM
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3EUG
| CRYSTAL STRUCTURE OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE AND ITS COMPLEXES WITH URACIL AND GLYCEROL: STRUCTURE AND GLYCOSYLASE MECHANISM REVISITED | Descriptor: | GLYCEROL, PROTEIN (GLYCOSYLASE) | Authors: | Xiao, G, Tordova, M, Jagadeesh, J, Drohat, A.C, Stivers, J.T, Gilliland, G.L. | Deposit date: | 1998-10-13 | Release date: | 1999-10-13 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited. Proteins, 35, 1999
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3FCF
| Complex of UNG2 and a fragment-based designed inhibitor | Descriptor: | 3-[(1E,7E)-8-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-3,6-dioxa-2,7-diazaocta-1,7-dien-1-yl]benzoic acid, THIOCYANATE ION, Uracil-DNA glycosylase | Authors: | Bianchet, M.A, Chung, S, Parker, J.B, Amzel, L.M, Stivers, J.T. | Deposit date: | 2008-11-21 | Release date: | 2009-04-28 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Impact of linker strain and flexibility in the design of a fragment-based inhibitor Nat.Chem.Biol., 5, 2009
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3FCI
| Complex of UNG2 and a fragment-based designed inhibitor | Descriptor: | 3-{(E)-[(3-{[(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methyl]amino}propoxy)imino]methyl}benzoic acid, SODIUM ION, THIOCYANATE ION, ... | Authors: | Bianchet, M.A, Chung, S, Parker, J.B, Amzel, L.M, Stivers, J.T. | Deposit date: | 2008-11-21 | Release date: | 2009-04-28 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.27 Å) | Cite: | Impact of linker strain and flexibility in the design of a fragment-based inhibitor Nat.Chem.Biol., 5, 2009
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3FCK
| Complex of UNG2 and a fragment-based design inhibitor | Descriptor: | 3-({[3-({[(1E)-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methylidene]amino}oxy)propyl]amino}methyl)benzoic acid, Uracil-DNA glycosylase | Authors: | Bianchet, M.A, Chung, S, Parker, J.B, Amzel, L.M, Stivers, J.T. | Deposit date: | 2008-11-21 | Release date: | 2009-04-28 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Impact of linker strain and flexibility in the design of a fragment-based inhibitor Nat.Chem.Biol., 5, 2009
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3FCL
| Complex of UNG2 and a fragment-based designed inhibitor | Descriptor: | 3-{[(4-{[(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methyl]amino}butyl)amino]methyl}benzoic acid, THIOCYANATE ION, Uracil-DNA glycosylase | Authors: | Bianchet, M.A, Chung, S, Parker, J.B, Amzel, L.M, Stivers, J.T. | Deposit date: | 2008-11-21 | Release date: | 2009-04-28 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Impact of linker strain and flexibility in the design of a fragment-based inhibitor Nat.Chem.Biol., 5, 2009
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3IKB
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3TKB
| crystal structure of human uracil-DNA glycosylase D183G/K302R mutant | Descriptor: | IMIDAZOLE, Uracil-DNA glycosylase | Authors: | Assefa, N.G, Niiranen, L, Willassen, N.P, Smalas, A.O, Moe, E. | Deposit date: | 2011-08-26 | Release date: | 2011-10-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Thermal unfolding studies of cold adapted uracil-DNA N-glycosylase (UNG) from Atlantic cod (Gadus morhua). A comparative study with human UNG. Comp.Biochem.Physiol. B: Biochem.Mol.Biol., 161, 2012
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3TR7
| Structure of a uracil-DNA glycosylase (ung) from Coxiella burnetii | Descriptor: | Uracil-DNA glycosylase | Authors: | Cheung, J, Franklin, M.C, Rudolph, M, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | Deposit date: | 2011-09-09 | Release date: | 2011-09-21 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (2.1958 Å) | Cite: | Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
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3UF7
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3UFJ
| Human Thymine DNA Glycosylase Bound to Substrate Analog 2'-fluoro-2'-deoxyuridine | Descriptor: | 5'-D(*CP*AP*GP*CP*TP*CP*TP*GP*TP*AP*CP*GP*TP*GP*AP*GP*CP*AP*GP*TP*GP*GP*A)-3', 5'-D(*CP*CP*AP*CP*TP*GP*CP*TP*CP*AP*(UF2)P*GP*TP*AP*CP*AP*GP*AP*GP*CP*TP*GP*T)-3', G/T mismatch-specific thymine DNA glycosylase | Authors: | Pozharski, E, Maiti, A, Drohat, A.C. | Deposit date: | 2011-11-01 | Release date: | 2012-04-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.967 Å) | Cite: | Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA. Proc.Natl.Acad.Sci.USA, 109, 2012
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3UFM
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3UO7
| Crystal structure of Human Thymine DNA Glycosylase Bound to Substrate 5-carboxylcytosine | Descriptor: | 5'-D(*CP*AP*GP*CP*TP*CP*TP*GP*TP*AP*CP*AP*TP*GP*AP*GP*CP*AP*GP*TP*GP*GP*A)-3', 5'-D(*CP*CP*AP*CP*TP*GP*CP*TP*CP*AP*(1CC)P*GP*TP*AP*CP*AP*GP*AP*GP*CP*TP*GP*T)-3', G/T mismatch-specific thymine DNA glycosylase | Authors: | Zhang, L, He, C. | Deposit date: | 2011-11-16 | Release date: | 2012-02-15 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.002 Å) | Cite: | Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA. Nat.Chem.Biol., 8, 2012
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3UOB
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3WDF
| Staphylococcus aureus UDG | Descriptor: | Uracil-DNA glycosylase | Authors: | Wang, H.C, Ko, T.P, Wang, A.H.J. | Deposit date: | 2013-06-18 | Release date: | 2014-02-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Staphylococcus aureus protein SAUGI acts as a uracil-DNA glycosylase inhibitor. Nucleic Acids Res., 42, 2013
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3WDG
| Staphylococcus aureus UDG / UGI complex | Descriptor: | Uncharacterized protein, Uracil-DNA glycosylase | Authors: | Wang, H.C, Ko, T.P, Wang, A.H.J. | Deposit date: | 2013-06-18 | Release date: | 2014-02-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Staphylococcus aureus protein SAUGI acts as a uracil-DNA glycosylase inhibitor. Nucleic Acids Res., 42, 2013
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3ZOQ
| Structure of BsUDG-p56 complex | Descriptor: | CHLORIDE ION, GLYCEROL, P56, ... | Authors: | Banos-Sanz, J.I, Mojardin, L, Sanz-Aparicio, J, Gonzalez, B, Salas, M. | Deposit date: | 2013-02-22 | Release date: | 2013-05-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Crystal Structure and Functional Insights Into Uracil-DNA Glycosylase Inhibition by Phage Phi29 DNA Mimic Protein P56 Nucleic Acids Res., 41, 2013
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3ZOR
| Structure of BsUDG | Descriptor: | URACIL-DNA GLYCOSYLASE | Authors: | Banos-Sanz, J.I, Mojardin, L, Sanz-Aparicio, J, Gonzalez, B, Salas, M. | Deposit date: | 2013-02-22 | Release date: | 2013-05-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Crystal Structure and Functional Insights Into Uracil-DNA Glycosylase Inhibition by Phage Phi29 DNA Mimic Protein P56 Nucleic Acids Res., 41, 2013
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4EUG
| Crystallographic and Enzymatic Studies of an Active Site Variant H187Q of Escherichia Coli Uracil DNA Glycosylase: Crystal Structures of Mutant H187Q and its Uracil Complex | Descriptor: | PROTEIN (GLYCOSYLASE) | Authors: | Xiao, G, Tordova, M, Drohat, A.C, Jagadeesh, J, Stivers, J.T, Gilliland, G.L. | Deposit date: | 1998-12-27 | Release date: | 1999-07-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Heteronuclear NMR and crystallographic studies of wild-type and H187Q Escherichia coli uracil DNA glycosylase: electrophilic catalysis of uracil expulsion by a neutral histidine 187. Biochemistry, 38, 1999
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4FNC
| Human TDG in a post-reactive complex with 5-hydroxymethyluracil (5hmU) | Descriptor: | 5-HYDROXYMETHYL URACIL, DNA (28-MER), DNA (29-MER), ... | Authors: | Hashimoto, H, Hong, S, Bhagwat, A.S, Zhang, X, Cheng, X. | Deposit date: | 2012-06-19 | Release date: | 2012-09-19 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.493 Å) | Cite: | Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation. Nucleic Acids Res., 40, 2012
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4JGC
| Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC) | Descriptor: | 4-amino-2-oxo-1,2-dihydropyrimidine-5-carboxylic acid, G/T mismatch-specific thymine DNA glycosylase, oligonucleotide, ... | Authors: | Hashimoto, H, Zhang, X, Cheng, X. | Deposit date: | 2013-02-28 | Release date: | 2013-05-29 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.582 Å) | Cite: | Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH. Dna Repair, 12, 2013
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4L5N
| Crystallographic Structure of HHV-1 Uracil-DNA Glycosylase complexed with the Bacillus phage PZA inhibitor protein p56 | Descriptor: | ACETATE ION, Early protein GP1B, Uracil-DNA glycosylase | Authors: | Cole, A.R, Sapir, O, Ryzhenkova, K, Baltulionis, G, Hornyak, P, Savva, R. | Deposit date: | 2013-06-11 | Release date: | 2013-08-07 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Architecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase. Nucleic Acids Res., 41, 2013
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